Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7252-7265

  Khan, M A ^a   Aberham, C ^a   Kao, S ^a   Akari, H ^a   Gorelick, R ^a   Bour, S ^a   Strebel, K ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIF PROTEIN; VIRUS NUCLEOPROTEIN; VIRUS RNA; ZINC FINGER PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; VIRION; VIRUS INFECTIVITY; VIRUS PARTICLE;

GENE PRODUCTS, VIF; GENOME, VIRAL; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; NUCLEOPROTEINS; PROTEIN BINDING; RNA, VIRAL; VIRUS ASSEMBLY; ZINC FINGERS;

EID: 0034899286     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7252-7265.2001     Document Type: Article

References (72)

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells
3. Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of vif for optimal infectivity: Functional difference between Vif and Nef
4. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus
5. Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations
6. Transcomplementation of VIF- HIV-1 mutants in CEM cells suggests that VIF affects late steps of the viral life cycle
7. Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: Role of Vif in correct particle assembly and infectivity
8. Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor
9. Phenotypically Vif-human immunodeficiency virus type 1 is produced by chronically infected restrictive cells
10. Characterization of human immunodeficiency virus type 1 Vif particle incorporation
11. vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus
12. Human immunodeficiency virus vpr product is a virion-associated regulatory protein
13. Peripheral blood mononuclear cells produce normal amounts of defective Vif- human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps
14. Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues
15. Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription
16. Highly purified human immunodeficiency virus type 1 reveals a virtual absence of Vif in virions
17. Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein
18. Partial rescue of the vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription
19. Cell-free transmission of Vif mutants of HIV-1
20. The sor gene of HIV-1 is required for efficient virus transmission in vitro
21. Human immunodeficiency virus type 1 Vif does not influence expression or virion incorporation of gag-, pol-, and env-encoded proteins
22. + T lymphocytes
23. Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations
24. Subcellular localization of the Vif protein of human immunodeficiency virus type 1
25. Role of Vif in human immunodeficiency virus type 1 reverse transcription
26. Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains
27. Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: Characterization of HIV-1 particles containing mutant nucleocapsid zinc- coordinating sequences
28. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA
29. Folding of the multidomain human immunodeficiency virus type-1 integrase
30. Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transfer
31. Fully functional, naturally occurring and C-terminally truncated variant human immunodeficiency virus (HIV) Vif does not bind to HIV Gag but influences intermediate filament structure
32. Role of vif during packing of the core of HIV-1
33. Interaction and coencapsidation of human immunodeficiency virus type 1 Gag and Vif recombinant proteins
34. Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein
35. Cells surviving infection by human immunodeficiency virus type 1: Vif or vpu mutants produce non-infectious or markedly less cytopathic viruses
36. gag required for the incorporation of human immunodeficiency virus type 1 Vpr
37. gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles
38. Association of Nef with the human immunodeficiency virus type 1 core
39. The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures
40. Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity
41. An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein
42. High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells
43. The replicative impairment of Vif-mutants of human immunodeficiency virus type 1 correlates with an overall defect in viral DNA synthesis
44. Conservation of amino-acid sequence motifs in lentivirus Vif proteins
45. Analysis of vif-defective human immunodeficiency virus type 1 (HIV-1) virions synthesized in 'non-permissive' T lymphoid cells stably infected with selectable HIV-1
46. Role of vif in stability of the human immunodeficiency virus type 1 core
47. Incorporation of Vpr into human immunodeficiency virus type 1 virions: Requirement for the p6 region of gag and mutational analysis
48. Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants
49. Characterization of highly purified, inactivated HIV-1 particles isolated by anion exchange chromatography
50. Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step
51. Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles
52. Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes
53. The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells
54. Evidence for a newly discovered cellular anti-HIV-1 phenotype
55. The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes
56. Virion incorporation of human immunodeficiency virus type-1 Vif is determined by intracellular expression level and may not be necessary for function
57. The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: A role for Vif in determining virus host range and cross-species transmission
58. Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes
59. Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
60. The redox state of cysteines in human immunodeficiency virus type 1 Vif in infected cells and in virions
61. Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1
62. The HIV 'A' (sor) gene product is essential for virus infectivity
63. A novel gene of HIV-1, vpu, and its 16-kilodalton product
64. Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus
65. HIV accessory proteins: Leading roles for the supporting cast
66. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells
67. Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160
68. Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein
69. A general method for the generation of high-titer, pantropic retroviral vectors: Highly efficient infection of primary hepatocytes
70. gag domain result in reduced retention of Pol proteins during virus assembly
71. Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein
72. Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process