Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: Evidence supporting a role for Nef at the virion envelope

Journal of Virology

Volumn 75, Issue 13, 2001, Pages 5851-5859

  Zhou, J ^a   Aiken, C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; NEF PROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN;

ARTICLE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; VIRION; VIRUS DETECTION; VIRUS GENOME; VIRUS PARTICLE;

CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; GENE PRODUCTS, NEF; HELA CELLS; HIV-1; HUMANS; VIRION;

EID: 0034972366     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.13.5851-5859.2001     Document Type: Article

References (40)

1. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
2. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
3. Efficient infection mediated by viral receptors incorporated into retroviral particles
4. Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
5. A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication
6. Human immunodeficiency virus type 1 particles pseudotyped by envelope proteins that fuse at low pH no longer require Nef for optimal infectivity
7. High-efficiency transformation of mammalian cells by plasmid DNA
8. The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
9. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
10. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
11. Identification of a major co-receptor for primary isolates of HIV-1
12. HIV-1 regulatory/accessory genes: Keys to unraveling viral and host cell biology
13. Targeting of HIV- and SIV- infected cells by CD4-chemokine receptor pseudotypes
14. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
15. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
16. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
17. Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
18. Association of Nef with the human immunodeficiency virus type 1 core
19. Packaging system for rapid production of murine leukemia virus vectors with variable tropism
20. Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: Implications for HIV-based gene transfer systems
21. Interaction of influenza virus hemagglutinin with target membrane lipids is a key step in virus-induced hemolysis and fusion at pH 5.2
22. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
23. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection
24. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
25. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
26. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
27. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
28. HIV Nef: The mother of all evil?
29. The nef gene from a long-term HIV type 1 nonprogressor
30. Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor
31. Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
32. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
33. Membrane fusion between retroviral particles: Host-range extension and vaccine prospects
34. p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents
35. Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: Analysis of its role in enhancement of viral infectivity
36. Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
37. pH-dependent fusion between the Semliki Forest virus membrane and liposomes
38. Membrane fusion activity of influenza virus
39. Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites
40. Generation of high-titer pseudotyped retroviral with very broad host range