LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-α

Blood

Volumn 95, Issue 12, 2000, Pages 3823-3831

  Xaus, Jordi ^b   Comalada, Mònica ^b   Valledor, Annabel F ^b   Lloberas, Jorge ^b   López Soriano, Francisco ^b   Argilés, Josep M ^b   Bogdan, Christian ^b   Celada, Antonio ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; ENZYME INDUCTION; GENE INDUCTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0034660130     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.12.3823     Document Type: Article

References (78)

1. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844-2853.
2. Valledor AF, Borras FE, Cullell-Young M, Celada A. Transcription factors that regulate monocyte/ macrophage differentiation. J Leukoc Biol. 1998; 63:405-417.
3. Celada A, Nathan CF. Macrophage activation revisited. Immunol Today. 1994;15:100-102.
4. Schereiber RD, Hicks LJ, Celada A, Buchmeier NA, Gray PW. Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol. 1985;134:1609-1618.
5. Morrison DC, Ryan JL. Endotoxins and disease mechanisms. Ann Rev Med. 1987;38:417-432.
6. Bone RC. Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions. Ann Int Med. 1991;114:332-333.
7. Marsh CB, Wewers MD. The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infection. Clin Chest Med. 1996;17:183-197.
8. Salkowski CA, Neta R, Wynn TA, Strassmann G, van Rooijen N, Vogel SN. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol. 1995;155:3168-3179.
9. Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet. 1991;338:1557-1558.
10. Beutler B, Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu Rev Biochem. 1988;57:505-518.
11. Parrillo JE. Pathogenic mechanisms of septic shock. N Engl J Med. 1993;328:1471-1477.
12. Parker MM, Shelhamer JH, Natanson C, Alling DW, Parrillo JE. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med. 1987;15:923-929.
13. Natanson C, Hoffman WD, Sutfredini AF, Eichacker PQ, Danner RL. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Annu Intern Med. 1994;120:771-783.
14. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 1992;257:387-389.
15. Thiemermann C. The role of the L-arginine: nitric oxide pathway in circulatory shock. Adv Pharmacol. 1994;28:45-79.
16. G-monomethyl-L-arginine or indomethacin. J Pharmacol Exp Ther. 1995;272:452-459.
17. MacMicking JD, Nathan C, Hom G, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 1995;81:641-650.
18. Laubach VE, Shesely EG, Smithies O, Sherman PA. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci USA. 1995;92:10688-10692.
19. Wei XQ, Charles IG, Smith A, et al. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995;375:408-411.
20. Evans T, Carpenter A, Silva A, Cohen J. Inhibition of nitric oxide synthase in experimental gram-negative sepsis. J Infect Dis. 1994;169:343-349.
21. Kilburn RG, Jubran A, Gross SS, et al. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun. 1990;172:1132-1138.
22. Szabo C, Southan GJ, Thiernermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiurea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994;91:12472-12476.
23. G-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrite biosynthesis while promoting hepatic damage. J Leukoc Biol. 1990;48:565-569.
24. Minnard EA, Shou J, Naama H, Cech A, Gallagher H, Daly JM. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg. 1994;129:142-147.
25. Beutler B, Cerami A. The biology of cachectin/ TNF-α primary mediator of the host response. Annu Rev Immunol. 1989;7:625-655.
26. Vasalli P. The pathophysiology of tumor necrosis factor. Annu Rev Immunol. 1992;10:411-452.
27. Tracey KJ, Beutler B, Lowry SF, et al. Shock and tissue injury induced by recombinant human cachectin. Science. 1986;234:470-474.
28. Beutler B, Milsark IW, Cerami A. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 1985;229:869-871.
29. Tracey KJ, Fong Y, Hesse DG, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987; 330:662-664.
30. Goodwin RG, Anderson D, Jerzy R, et al. Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol. 1991;11:3020-3026.
31. Lewis M, Tartaglia LA, Lee A, et al. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A. 1991;88:2830-2834.
32. Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA, Goeddel DV. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc Natl Acad Sci U S A. 1991;88:9292-9296.
33. Thoma B, Grell M, Pfizenmaier K, Scheurich P. Identification of a 60 kd tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J Exp Med. 1990; 172:1019-1023.
34. Tartaglia LA, Goeddel DV. Two TNF receptors. Immunol Today. 1992;13:151-153.
35. Heller RA, Song K, Fan N, Chang D. The p70 tumor necrosis factor receptor mediates cytotoxicity. Cell. 1990;70:47-56.
36. Leist M, Gantner F, Jilg S, Wendel A. Activation of the 55kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol. 1995; 154:1307-1316.
37. Tartaglia LA, Rothe M, Hu Y Goeddel DV. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell. 1993;73:213-216.
38. Tartaglia LA, Ayres M, Wong GHW, Goeddel DV. A novel domain within the 55 kd TNF receptor signals cell death. Cell. 1993;74:845-853.
39. Greenblatt MS, Elias L. The type B receptor for tumor necrosis factor-α mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells. Blood. 1992;80:1339-1346.
40. Pfeffer K, Matsuyama T, Kundig TM, et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 1993; 73:457-467.
41. Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol. 1993;150:5080-5085.
42. Sarih M, Souvannavong V, Adam A. Nitric oxide synthase induces macrophage death by apoptosis. Biochem Biophys Res Commun. 1993;191: 503-508.
43. Murray J, Barbara JA, Dunkley SA, et al. Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood. 1997;90:2772-2783.
44. Torczynski RM, Bollon AP, Fuke M. The complete nucleotide sequence of the rat 18S ribosomal RNA gene and comparison with the respective yeast and frog genes. Nucleic Acids Res. 1983; 11:4879-4890.
45. Celada A, Gray PW, Rinderknecht E, Schreiber RD. Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity. J Exp Med. 1984;160:55-74.
46. Zhang Y, Harada A, Bluethmann H, et al. Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vitro. Blood. 1995;86:2930-2937.
47. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK. Altered neuronal and microglial responses to excitoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med. 1996;2:788-794.
48. Diefenbach A, Schindler H, Donhauser N, et al. Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity. 1998;8:77-87.
49. Hogquist KA, Nett MA, Unanue ER, Chaplin DD. Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci U S A. 1991;88: 8485-8489.
50. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
51. Perera PY, Vogel SN, Detore GR, Haziot A, Goyert SM. CD-14 dependent and CD-14-independent signaling pathways in murine macrophages from normal and CD-14 knockout mice stimulated with lipopolysaccharide or taxol. J Immunol. 1997;158:4422-4429.
52. Schumann RR, Leong SR, Flaggs GW, et al. Structure and function of lipopolysaccharide binding protein. Science. 1990;249:1429-1431.
53. Lakics V, Vogel SN. Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages. J Immunol. 1998;161:2490-2500.
54. Heneka MT, Loschmann PA, Gleichmann M, et al. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J Neurochem. 1998;71:88-94.
55. Fehsel K, Kroncke KD, Meyer KL, Huber H, Whan V, Kolb-Bachofen V. Nitric oxide induces apoptosis in mouse thymocytes. J Immunol. 1995;155:2858-2865.
56. Southam GJ, Szabo C, Thiemermann C. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol. 1995;114:510-516.
57. Mathison JC, Wolfson E, Ulevitch RJ. Participation of tumor necrosis factor in the mediation of Gram negative bacterial lipopolysaccharide-induced injury in rabbits. J Clin Invest. 1998;81: 1925-1937.
58. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
59. Gottlieb TM, Oren M. p53 in growth control and neoplasia. Biochem Biophys. 1996;1287:77-102.
60. Xiang J, Chao DT, Korsmeyer SJ. Bax-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci U S A. 1996;93:14559-14563.
61. Messmer UK, Reed UK, Brune B. Bcl-2 protects macrophages from nitric oxide-induced apoptosis. J Biol Chem. 1996;271:20192-20197.
62. Wong GH, Elwell JH, Oberley LW, Goeddel DV. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell. 1989;58:923-931.
63. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 1996;274:782-784.
64. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 1996;274:787-789.
65. Ayala A, Karr SM, Evans TA, Chaudry IH. Factors responsible for peritoneal granulocyte apoptosis during sepsis. J Surg Res. 1997;69:67-75.
66. Denecker G, Vandenabeele P, Grooten J, et al. Differential role of calcium in tumor necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine. 1997;9:631-638.
67. Akassoglou K, Bauer J, Kassiotis G, et al. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol. 1998;153:801-813.
68. Nussler AK, Drapier JC, Renia L, et al. L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation. Eur J Immunol. 1991;21:227-230.
69. Nussler AK, Di Silvio M, Billiar TR, et al. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med. 1992;176:261-264.
70. Nussler AK, Billiar TR. Inflammation, immuno-regulation, and inducible nitric oxide synthase. J Leukoc Biol. 1993;54:171-178.
71. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308.
72. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81:505-512.
73. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/Apo-1-and TNF receptor-induced cell death. Cell. 1996;85:803-815.
74. Brune B, Gotz C, Messmer UK, et al. Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis. J Biol Chem. 1997; 272:7253-7258.
75. Kitada S, Krajewski S, MiyashitaT, et al. γ-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo. Oncogene. 1996;12:187-192.
76. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome C from isolated mitochondria. Proc Natl Acad Sci USA. 1998;95:4997-5002.
77. Reed, JC. Double identity for proteins of the Bcl-2 family. Nature. 1997;387:773-776.
78. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312.