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Volumn 1, Issue 4, 2001, Pages 343-355

Growth factors in pancreatic health and disease

Author keywords

Chronic pancreatitis; Growth factor receptors; Growth factors; Pancreatic cancer

Indexed keywords

GROWTH PROMOTOR; PANCRELIPASE;

EID: 0035553423     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000055833     Document Type: Conference Paper
Times cited : (17)

References (162)
  • 1
    • 0024393005 scopus 로고
    • Pathogenesis and epidemiology of chronic pancreatitis
    • Sarles H, Bernard JP, Johnson C, Chir M: Pathogenesis and epidemiology of chronic pancreatitis. Annu Rev Med 1989;40:453-468.
    • (1989) Annu Rev Med , vol.40 , pp. 453-468
    • Sarles, H.1    Bernard, J.P.2    Johnson, C.3    Chir, M.4
  • 2
    • 0002082545 scopus 로고
    • Chronic pancreatitis
    • Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): New York, Raven Press
    • DiMagno EP, Layer P, Clain JE: Chronic pancreatitis; in Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): The Exocrine Pancreas: Biology, Pathobiology, and Diseases. New York, Raven Press, 1993, pp 665-706.
    • (1993) The Exocrine Pancreas: Biology, Pathobiology, and Diseases , pp. 665-706
    • DiMagno, E.P.1    Layer, P.2    Clain, J.E.3
  • 3
    • 0027265705 scopus 로고
    • A short, eclectic history of exocrine pancreatic insufficiency and chronic pancreatitis
    • DiMagno EP: A short, eclectic history of exocrine pancreatic insufficiency and chronic pancreatitis. Gastroenterology 1993;104:1255-1262.
    • (1993) Gastroenterology , vol.104 , pp. 1255-1262
    • DiMagno, E.P.1
  • 4
    • 0029188785 scopus 로고
    • Chronic pancreatitis with inflammatory enlargement of the pancreatic head
    • Friess H, Müller M, Ebert M, Büchler MW: Chronic pancreatitis with inflammatory enlargement of the pancreatic head. Zentralbl Chir 1995;120:292-297.
    • (1995) Zentralbl Chir , vol.120 , pp. 292-297
    • Friess, H.1    Müller, M.2    Ebert, M.3    Büchler, M.W.4
  • 5
    • 0001485370 scopus 로고
    • Surgical anatomy of the pancreas and adjacent structures
    • Beger HG, Büchler M, Malfertheiner P (eds): New York, Springer
    • Bockman DE: Surgical anatomy of the pancreas and adjacent structures; in Beger HG, Büchler M, Malfertheiner P (eds): Standards in Pancreatic Surgery. New York, Springer, 1993, pp 1-9.
    • (1993) Standards in Pancreatic Surgery , pp. 1-9
    • Bockman, D.E.1
  • 7
    • 0002082545 scopus 로고
    • Chronic pancreatitis
    • Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): New York, Raven Press
    • Di Magno EP, Layer P, Clain JE: Chronic pancreatitis; in Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds): The Pancreas. New York, Raven Press, 1993, pp 707-740.
    • (1993) The Pancreas , pp. 707-740
    • Di Magno, E.P.1    Layer, P.2    Clain, J.E.3
  • 8
    • 0012006967 scopus 로고
    • Conservative management of chronic pancreatitis
    • Beger HG, Büchler M, Malfertheiner P (eds): New York, Springer
    • Di Magno EP: Conservative management of chronic pancreatitis; in Beger HG, Büchler M, Malfertheiner P (eds): Standards in Pancreatic Surgery. New York, Springer, 1993, pp 325-331.
    • (1993) Standards in Pancreatic Surgery , pp. 325-331
    • Di Magno, E.P.1
  • 13
    • 0025727978 scopus 로고
    • Pseudocysts in chronic pancreatitis: A morphological analysis of 57 resection specimens and 9 autopsy pancreata
    • Klöppel G, Maillet B: Pseudocysts in chronic pancreatitis: A morphological analysis of 57 resection specimens and 9 autopsy pancreata. Pancreas 1991;6:266-274.
    • (1991) Pancreas , vol.6 , pp. 266-274
    • Klöppel, G.1    Maillet, B.2
  • 14
    • 0012190148 scopus 로고
    • Early pathomorphological pancreatic changes in chronic alcoholism
    • Gyr KE, Singer MV, Sarles H (eds): Amsterdam, North Holland/Elsevier
    • Bordalo O, Bapista A, Dreiling D, Noronha M: Early pathomorphological pancreatic changes in chronic alcoholism; in Gyr KE, Singer MV, Sarles H (eds): Pancreatitis - Concepts and classification. Amsterdam, North Holland/Elsevier, 1984, No 642.
    • (1984) Pancreatitis - Concepts and Classification , vol.642
    • Bordalo, O.1    Bapista, A.2    Dreiling, D.3    Noronha, M.4
  • 15
    • 0021038544 scopus 로고
    • Pancreatic disease: A casualty of hepatic 'detoxification'?
    • Braganza JM: Pancreatic disease: A casualty of hepatic 'detoxification'? Lancet 1983;8357: 1000-1003.
    • (1983) Lancet , vol.8357 , pp. 1000-1003
    • Braganza, J.M.1
  • 16
    • 0027265705 scopus 로고
    • A short, eclectic history of exocrine pancreatic insufficiency and chronic pancreatitis
    • DiMagno EP: A short, eclectic history of exocrine pancreatic insufficiency and chronic pancreatitis. Gastroenterology 1993;104:1255-1262.
    • (1993) Gastroenterology , vol.104 , pp. 1255-1262
    • DiMagno, E.P.1
  • 17
    • 0030938319 scopus 로고    scopus 로고
    • Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis
    • Di Sebastiano P, Fink T, Weihe E, Friess H, Innocenti P, Beger HG, Büchler MW: Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis. Gastroenterology 1997;112: 1648-1655.
    • (1997) Gastroenterology , vol.112 , pp. 1648-1655
    • Di Sebastiano, P.1    Fink, T.2    Weihe, E.3    Friess, H.4    Innocenti, P.5    Beger, H.G.6    Büchler, M.W.7
  • 18
    • 0030973672 scopus 로고    scopus 로고
    • Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis
    • Hunger RE, Mueller C, Z'graggen K, Friess H, Büchler MW: Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis. Gastroenterology 1997;112:1656-1663.
    • (1997) Gastroenterology , vol.112 , pp. 1656-1663
    • Hunger, R.E.1    Mueller, C.2    Z'Graggen, K.3    Friess, H.4    Büchler, M.W.5
  • 20
    • 0026483736 scopus 로고
    • Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor
    • Bockman DE, Merlino G: Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor. Gastroenterology 1992;103:1883-1892.
    • (1992) Gastroenterology , vol.103 , pp. 1883-1892
    • Bockman, D.E.1    Merlino, G.2
  • 23
    • 0019139043 scopus 로고
    • Epidermal growth factor is a major growth-promoting agent in human milk
    • Carpenter G: Epidermal growth factor is a major growth-promoting agent in human milk. Science 1980;210:198-199.
    • (1980) Science , vol.210 , pp. 198-199
    • Carpenter, G.1
  • 24
    • 0022545230 scopus 로고
    • A physiological role of epidermal growth factor in male reproductive function
    • Tsutsumi O, Kurachi H, Oka T: A physiological role of epidermal growth factor in male reproductive function. Science 1986;233:975-977.
    • (1986) Science , vol.233 , pp. 975-977
    • Tsutsumi, O.1    Kurachi, H.2    Oka, T.3
  • 25
    • 0025146497 scopus 로고
    • The epidermal growth factor: A review of structural and functional relationships in the normal organism and in cancer cells
    • Laurence DJ, Gusterson BA: The epidermal growth factor: A review of structural and functional relationships in the normal organism and in cancer cells. Tumor Biol 1990;11:229-261.
    • (1990) Tumor Biol , vol.11 , pp. 229-261
    • Laurence, D.J.1    Gusterson, B.A.2
  • 27
    • 0030911331 scopus 로고    scopus 로고
    • Ligands for ErbB-family receptors encoded by a neuregulin-like gene
    • Chang H, Riese DJ 2nd, Gilbert W, Stern DF, McMahan UJ: Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 1997;387:509-512.
    • (1997) Nature , vol.387 , pp. 509-512
    • Chang, H.1    Riese II, D.J.2    Gilbert, W.3    Stern, D.F.4    McMahan, U.J.5
  • 28
    • 0000315837 scopus 로고    scopus 로고
    • Structure and function of heparin-binding EGF-like growth factor (HB-EGF)
    • Davis-Fleischer KM, Besner GE: Structure and function of heparin-binding EGF-like growth factor (HB-EGF). Front Biosci 1998;3:288-299.
    • (1998) Front Biosci , vol.3 , pp. 288-299
    • Davis-Fleischer, K.M.1    Besner, G.E.2
  • 29
    • 0026520472 scopus 로고
    • The physiology of transforming growth factor-α
    • Derynck R: The physiology of transforming growth factor-α. Adv Cancer Res 1992;58:27-52.
    • (1992) Adv Cancer Res , vol.58 , pp. 27-52
    • Derynck, R.1
  • 33
    • 0030930304 scopus 로고    scopus 로고
    • Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family
    • Toyoda H, Komurasaki T, Uchida D, Morimoto S: Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. Biochem J 1997;326:69-75.
    • (1997) Biochem J , vol.326 , pp. 69-75
    • Toyoda, H.1    Komurasaki, T.2    Uchida, D.3    Morimoto, S.4
  • 36
    • 0027501659 scopus 로고
    • Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene
    • Sarkar FH, Ball DE, Li YW, Crissman JD: Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene. DNA Cell Biol 1993;12:611-615.
    • (1993) DNA Cell Biol , vol.12 , pp. 611-615
    • Sarkar, F.H.1    Ball, D.E.2    Li, Y.W.3    Crissman, J.D.4
  • 37
    • 0026487597 scopus 로고
    • The type 1 (EGFR-related) family of growth factor receptors and their ligands
    • Prigent SA, Lemoine NR: The type 1 (EGFR-related) family of growth factor receptors and their ligands. Prog Growth Factor Res 1992;4: 1-24.
    • (1992) Prog Growth Factor Res , vol.4 , pp. 1-24
    • Prigent, S.A.1    Lemoine, N.R.2
  • 38
    • 0024326947 scopus 로고
    • Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors
    • Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci USA 1989;86: 9193-9197.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9193-9197
    • Kraus, M.H.1    Issing, W.2    Miki, T.3    Popescu, N.C.4    Aaronson, S.A.5
  • 39
    • 0028176477 scopus 로고
    • A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
    • Carraway KL 3rd, Cantley LC: A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling. Cell 1994;78:5-8.
    • (1994) Cell , vol.78 , pp. 5-8
    • Carraway III, K.L.1    Cantley, L.C.2
  • 40
    • 0026793456 scopus 로고
    • Growth factor signaling by receptor tyrosine kinases
    • Schlessinger J, Ullrich A: Growth factor signaling by receptor tyrosine kinases. Neuron 1992; 9:383-391.
    • (1992) Neuron , vol.9 , pp. 383-391
    • Schlessinger, J.1    Ullrich, A.2
  • 41
    • 0031936410 scopus 로고    scopus 로고
    • Specificity within the EGF family/ErbB receptor family signaling network
    • Riese DJ 2nd, Stern DF: Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 1998;20:41-48.
    • (1998) Bioessays , vol.20 , pp. 41-48
    • Riese II, D.J.1    Stern, D.F.2
  • 42
    • 0031044540 scopus 로고    scopus 로고
    • The neurotrophic action and signalling of epidermal growth factor
    • Yamada M, Ikeuchi T, Hatanaka H: The neurotrophic action and signalling of epidermal growth factor. Prog Neurobiol 1997;51:19-37.
    • (1997) Prog Neurobiol , vol.51 , pp. 19-37
    • Yamada, M.1    Ikeuchi, T.2    Hatanaka, H.3
  • 43
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • Cano E, Mahadevan LC: Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 1995;20:117-122.
    • (1995) Trends Biochem Sci , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 45
    • 0031044561 scopus 로고    scopus 로고
    • MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: Upstream regulators of the c-Jun amino-terminal kinases?
    • Fanger GR, Gerwins P, Widmann C, Jarpe MB, Johnson GL: MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: Upstream regulators of the c-Jun amino-terminal kinases? Curr Opin Genet Dev 1997;7:67-74.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 67-74
    • Fanger, G.R.1    Gerwins, P.2    Widmann, C.3    Jarpe, M.B.4    Johnson, G.L.5
  • 47
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG: The MAPK signaling cascade. FASEB J 1995;9:726-735.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 48
    • 0033885174 scopus 로고    scopus 로고
    • Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation
    • Floridon C, Jensen CH, Thorsen P, Nielsen O, Sunde L, Westergaard JG, Thomsen SG, Teisner B: Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 2000;66:49-59.
    • (2000) Differentiation , vol.66 , pp. 49-59
    • Floridon, C.1    Jensen, C.H.2    Thorsen, P.3    Nielsen, O.4    Sunde, L.5    Westergaard, J.G.6    Thomsen, S.G.7    Teisner, B.8
  • 50
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor-α
    • Korc M, Chandrasekar B, Yamanaka Y, Friess H, Büchler M, Beger HG: Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor-α. J Clin Invest 1992;90:1352-1360.
    • (1992) J Clin Invest , vol.90 , pp. 1352-1360
    • Korc, M.1    Chandrasekar, B.2    Yamanaka, Y.3    Friess, H.4    Büchler, M.5    Beger, H.G.6
  • 51
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • Yamanaka Y, Friess H, Kobrin MS, Büchler M, Beger HG, Korc M: Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993;13:565-570.
    • (1993) Anticancer Res , vol.13 , pp. 565-570
    • Yamanaka, Y.1    Friess, H.2    Kobrin, M.S.3    Büchler, M.4    Beger, H.G.5    Korc, M.6
  • 52
    • 0028102597 scopus 로고
    • Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor-α and phospholipase C-γ
    • Korc M, Friess H, Yamanaka Y, Kobrin M, Büchler MW, Beger HG: Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor-α and phospholipase C-γ. Gut 1994;35:1468-1473.
    • (1994) Gut , vol.35 , pp. 1468-1473
    • Korc, M.1    Friess, H.2    Yamanaka, Y.3    Kobrin, M.4    Büchler, M.W.5    Beger, H.G.6
  • 54
    • 0033065168 scopus 로고    scopus 로고
    • Serum and correspondent tissue measurements of epidermal growth factor and epidermal growth factor receptor. Clinical relevance in pancreatic cancer and chronic pancreatitis
    • Birk D, Gansauge F, Gansauge S, Formentini A, Lucht A, Beger HG: Serum and correspondent tissue measurements of epidermal growth factor and epidermal growth factor receptor. Clinical relevance in pancreatic cancer and chronic pancreatitis. Int J Pancreatol 1999;25: 89-96.
    • (1999) Int J Pancreatol , vol.25 , pp. 89-96
    • Birk, D.1    Gansauge, F.2    Gansauge, S.3    Formentini, A.4    Lucht, A.5    Beger, H.G.6
  • 55
    • 0028147728 scopus 로고
    • A subgroup of patients with chronic pancreatitis overexpress the c-erbB-2 protooncogene
    • 5 Friess H, Yamanaka Y, Büchler MW, Hammer K, Kobrin M, Beger HG: A subgroup of patients with chronic pancreatitis overexpress the c-erbB-2 protooncogene. Ann Surg 1994;220: 183-192.
    • (1994) Ann Surg , vol.220 , pp. 183-192
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.W.3    Hammer, K.4    Kobrin, M.5    Beger, H.G.6
  • 57
    • 0028799821 scopus 로고
    • Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression
    • Friess H, Yamanaka Y, Kobrin SM, Do DA, Büchler MW, Korc M: Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression. Clin Cancer Res 1995; 1:1413-1420.
    • (1995) Clin Cancer Res , vol.1 , pp. 1413-1420
    • Friess, H.1    Yamanaka, Y.2    Kobrin, S.M.3    Do, D.A.4    Büchler, M.W.5    Korc, M.6
  • 58
    • 0029890271 scopus 로고    scopus 로고
    • Transfection with a cripto antisense plasmid suppresses endogenous cripto expression and inhibits transformation in a human embryonal carcinoma cell line
    • Baldassarre G, Bianco C, Tortora G, Ruggiero A, Moasser M, Dmitrovsky E, Bianco AR, Ciardiello F: Transfection with a cripto antisense plasmid suppresses endogenous cripto expression and inhibits transformation in a human embryonal carcinoma cell line. Int J Cancer 1996;66:538-543.
    • (1996) Int J Cancer , vol.66 , pp. 538-543
    • Baldassarre, G.1    Bianco, C.2    Tortora, G.3    Ruggiero, A.4    Moasser, M.5    Dmitrovsky, E.6    Bianco, A.R.7    Ciardiello, F.8
  • 59
    • 0028296244 scopus 로고
    • Cripto, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer and chronic pancreatitis
    • Friess H, Yamanaka Y, Büchler MW, Kobrin MS, Tahara E, Korc M: Cripto, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer and chronic pancreatitis. Int J Cancer 1994;56: 668-674.
    • (1994) Int J Cancer , vol.56 , pp. 668-674
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.W.3    Kobrin, M.S.4    Tahara, E.5    Korc, M.6
  • 60
    • 0342312351 scopus 로고
    • Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis and migration
    • Moscatelli D, Presta M, Rifkin DB: Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis and migration. Proc Natl Acad Sci USA 1986;83:2091-2095.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2091-2095
    • Moscatelli, D.1    Presta, M.2    Rifkin, D.B.3
  • 61
    • 0023573994 scopus 로고
    • The opposing effects of basic fibroblast growth factor and transforming growth factor-β on the regulation of plasminogen activator activity in capillary endothelial cells
    • Saksela O, Moscatelli D, Rifkin DB: The opposing effects of basic fibroblast growth factor and transforming growth factor-β on the regulation of plasminogen activator activity in capillary endothelial cells. J Cell Biol 1987;105: 957-963.
    • (1987) J Cell Biol , vol.105 , pp. 957-963
    • Saksela, O.1    Moscatelli, D.2    Rifkin, D.B.3
  • 62
    • 0024339705 scopus 로고
    • The heparin-binding (fibroblast) growth factor family of proteins
    • Burgess WH, Maciag T: The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem 1989;58:575-606.
    • (1989) Annu Rev Biochem , vol.58 , pp. 575-606
    • Burgess, W.H.1    Maciag, T.2
  • 63
    • 0024869514 scopus 로고
    • The fibroblast growth factor family: Structural and biological properties
    • Klagsbrun M: The fibroblast growth factor family: Structural and biological properties. Prog Growth Factor Res 1989;1:207-235.
    • (1989) Prog Growth Factor Res , vol.1 , pp. 207-235
    • Klagsbrun, M.1
  • 64
    • 0023334956 scopus 로고
    • Biochemical comparative studies between eye and brain derived growth factors
    • Courty J, Loret C, Chevallier B, Moenner M, Barritault D: Biochemical comparative studies between eye and brain derived growth factors. Biochemie 1987;69:511-516.
    • (1987) Biochemie , vol.69 , pp. 511-516
    • Courty, J.1    Loret, C.2    Chevallier, B.3    Moenner, M.4    Barritault, D.5
  • 65
    • 0026736833 scopus 로고
    • The FGF family of growth factors and oncogenes
    • Basilico C, Moscatelli D: The FGF family of growth factors and oncogenes. Adv Cancer Res 1992;59:115-165.
    • (1992) Adv Cancer Res , vol.59 , pp. 115-165
    • Basilico, C.1    Moscatelli, D.2
  • 67
    • 0027050480 scopus 로고
    • Complexity of FGF receptors: Genetic basis for structural diversity and functional specificity
    • Givol D, Yayon A: Complexity of FGF receptors: Genetic basis for structural diversity and functional specificity. FASEB J 1992;6:3362-3369.
    • (1992) FASEB J , vol.6 , pp. 3362-3369
    • Givol, D.1    Yayon, A.2
  • 68
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson DE, Williams LT: Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993;60:1-41.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 69
    • 0031844173 scopus 로고    scopus 로고
    • Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis
    • Kornmann M, Beger HG, Korc M: Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis. Pancreas 1998;17:169-175.
    • (1998) Pancreas , vol.17 , pp. 169-175
    • Kornmann, M.1    Beger, H.G.2    Korc, M.3
  • 71
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsbrun M: Angiogenic factors. Science 1987;235:442-447.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 72
    • 0023335817 scopus 로고
    • Structural characterization and biological functions of fibroblast growth factor
    • Gospoderowicz D, Ferrara N, Schweigerer L, Neufeld G: Structural characterization and biological functions of fibroblast growth factor. Endocr Rev 1987;8:95-114.
    • (1987) Endocr Rev , vol.8 , pp. 95-114
    • Gospoderowicz, D.1    Ferrara, N.2    Schweigerer, L.3    Neufeld, G.4
  • 73
    • 0025214608 scopus 로고
    • Increased expression of genes for basic fibroblast growth factor and transforming growth factor type 2 in human benign prostatichyperplasia
    • Mori H, Maki M, Oishi K, Jaye M, Igarashi K, Yoshida O, Hatanaku M: Increased expression of genes for basic fibroblast growth factor and transforming growth factor type 2 in human benign prostatichyperplasia. Prostate 1990;16: 71-80.
    • (1990) Prostate , vol.16 , pp. 71-80
    • Mori, H.1    Maki, M.2    Oishi, K.3    Jaye, M.4    Igarashi, K.5    Yoshida, O.6    Hatanaku, M.7
  • 74
    • 0025291743 scopus 로고
    • In situ detection of basic fibroblast growth factor by highly specific antibodies
    • Schulze-Osthoff K, Risau W, Vollmer E, Sorg C: In situ detection of basic fibroblast growth factor by highly specific antibodies. Am J Pathol 1990;137:85-92.
    • (1990) Am J Pathol , vol.137 , pp. 85-92
    • Schulze-Osthoff, K.1    Risau, W.2    Vollmer, E.3    Sorg, C.4
  • 75
    • 0000836813 scopus 로고
    • Acidic and basic fibroblast growth factors and their receptors are expressed in the human pancreas
    • Friess H, Kobrin MS, Korc M: Acidic and basic fibroblast growth factors and their receptors are expressed in the human pancreas. Pancreas 1992;7:737.
    • (1992) Pancreas , vol.7 , pp. 737
    • Friess, H.1    Kobrin, M.S.2    Korc, M.3
  • 76
    • 0027435936 scopus 로고
    • Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage
    • Yamanaka Y, Friess H, Büchler M, Beger HG, Uchida E, Onda M, Kobrin MS, Korc M: Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res 1993; 53:5289-5296.
    • (1993) Cancer Res , vol.53 , pp. 5289-5296
    • Yamanaka, Y.1    Friess, H.2    Büchler, M.3    Beger, H.G.4    Uchida, E.5    Onda, M.6    Kobrin, M.S.7    Korc, M.8
  • 78
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague J: TGF-β signal transduction. Annu Rev Biochem 1998;67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 80
    • 0028845062 scopus 로고
    • Signaling by the transforming growth factor-β receptors
    • Yingling JM, Wang XF, Bassing CH: Signaling by the transforming growth factor-β receptors. Biochim Biophys Acta 1995;1242:115-136.
    • (1995) Biochim Biophys Acta , vol.1242 , pp. 115-136
    • Yingling, J.M.1    Wang, X.F.2    Bassing, C.H.3
  • 81
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massague J: The transforming growth factor-β family. Rev Cell Biol 1990;6:597-641.
    • (1990) Rev Cell Biol , vol.6 , pp. 597-641
    • Massague, J.1
  • 82
    • 0023724933 scopus 로고
    • Stimulatory effects of transforming growth factor-β and epidermal growth factor on epidermal cell outgrowth from porcine skin explant cultures
    • Hebda PA: Stimulatory effects of transforming growth factor-β and epidermal growth factor on epidermal cell outgrowth from porcine skin explant cultures. J Invest Dermatol 1988;91:440-445.
    • (1988) J Invest Dermatol , vol.91 , pp. 440-445
    • Hebda, P.A.1
  • 84
    • 0022471924 scopus 로고
    • Transforming growth factor type-β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • Roberts AB, Sporn MG, Assoian RK, Smith JM, Roche NS: Transforming growth factor type-β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83:4167-4171.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.G.2    Assoian, R.K.3    Smith, J.M.4    Roche, N.S.5
  • 85
    • 0026445528 scopus 로고
    • Transforming growth factor-β: Recent progress and new challenges
    • Sporn MB, Roberts AB: Transforming growth factor-β: Recent progress and new challenges. J Cell Biol 1992;119:1017-1021.
    • (1992) J Cell Biol , vol.119 , pp. 1017-1021
    • Sporn, M.B.1    Roberts, A.B.2
  • 86
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β
    • Roberts AB, Sporn MB: Physiological actions and clinical applications of transforming growth factor-β. Growth Factors 1993;8:1-9.
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 88
    • 0027195937 scopus 로고
    • Enhanced expression of the type II transforming growth factor-β receptor in human pancreatic cancer cells without alteration of type III receptor expression
    • Friess H, Yamanaka Y, Büchler M, Beger HG, Kobrin MS, Baldwin RL, Korc M: Enhanced expression of the type II transforming growth factor-β receptor in human pancreatic cancer cells without alteration of type III receptor expression. Cancer Res 1993;53:2704-2707.
    • (1993) Cancer Res , vol.53 , pp. 2704-2707
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.3    Beger, H.G.4    Kobrin, M.S.5    Baldwin, R.L.6    Korc, M.7
  • 89
    • 0026537831 scopus 로고
    • Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
    • Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF: Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992;68:775-785.
    • (1992) Cell , vol.68 , pp. 775-785
    • Lin, H.Y.1    Wang, X.F.2    Ng-Eaton, E.3    Weinberg, R.A.4    Lodish, H.F.5
  • 90
    • 0025987832 scopus 로고
    • Structure and expression of the membrane proteoglycan beta-glycan, a component of the TGF-β receptor system
    • Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J: Structure and expression of the membrane proteoglycan beta-glycan, a component of the TGF-β receptor system. Cell 1991;67:785-795.
    • (1991) Cell , vol.67 , pp. 785-795
    • Lopez-Casillas, F.1    Cheifetz, S.2    Doody, J.3    Andres, J.L.4    Lane, W.S.5    Massague, J.6
  • 92
    • 0027276765 scopus 로고
    • Beta-glycan presents ligand to the TGF-β signaling receptor
    • Lopez-Casillas F, Wrana JL, Massague J: Beta-glycan presents ligand to the TGF-β signaling receptor. Cell 1993;73:1435-1444.
    • (1993) Cell , vol.73 , pp. 1435-1444
    • Lopez-Casillas, F.1    Wrana, J.L.2    Massague, J.3
  • 95
    • 0030063574 scopus 로고    scopus 로고
    • Transforming growth factor-β promotes development of fibrosis after repeated courses of acute pancreatitis in mice
    • Van Laethem JL, Robberecht P, Resibios A, Deviere J: Transforming growth factor-β promotes development of fibrosis after repeated courses of acute pancreatitis in mice. Gastroenterology 1996;110:576-582.
    • (1996) Gastroenterology , vol.110 , pp. 576-582
    • Van Laethem, J.L.1    Robberecht, P.2    Resibios, A.3    Deviere, J.4
  • 97
    • 0025940119 scopus 로고
    • Platelet-derived growth factor in autocrine transformation
    • Westermark B, Heldin CH: Platelet-derived growth factor in autocrine transformation. Cancer Res 1991;51:5087-5092.
    • (1991) Cancer Res , vol.51 , pp. 5087-5092
    • Westermark, B.1    Heldin, C.H.2
  • 98
    • 0025464639 scopus 로고
    • Platelet-derived growth factor: Mechanism of action and possible in vivo function
    • Heldin CH, Westermark B: Platelet-derived growth factor: Mechanism of action and possible in vivo function. Cell Regul 1990;1:555-566.
    • (1990) Cell Regul , vol.1 , pp. 555-566
    • Heldin, C.H.1    Westermark, B.2
  • 101
    • 0023236055 scopus 로고
    • The nerve growth factor 35 years later
    • Levi-Montalcini R: The nerve growth factor 35 years later. Science 1987;237:1154-1162.
    • (1987) Science , vol.237 , pp. 1154-1162
    • Levi-Montalcini, R.1
  • 102
    • 0028931552 scopus 로고
    • Neurotrophic factors and their receptors
    • Barbacid M: Neurotrophic factors and their receptors. Curr Opin Cell Biol 1995;7:148-155.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 148-155
    • Barbacid, M.1
  • 108
    • 0026020115 scopus 로고
    • Transforming growth factor-α and epidermal growth factor in human pancreatic cancer
    • Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR: Transforming growth factor-α and epidermal growth factor in human pancreatic cancer. J Pathol 1991;163:111-116.
    • (1991) J Pathol , vol.163 , pp. 111-116
    • Barton, C.M.1    Hall, P.A.2    Hughes, C.M.3    Gullick, W.J.4    Lemoine, N.R.5
  • 109
  • 111
    • 0029147169 scopus 로고
    • Betacellulin, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer
    • Yokoyama M, Funatomi H, Kobrin MS, Ebert M, Friess H, Büchler MW, Korc M: Betacellulin, a member of the epidermal growth factor family, is overexpressed in human pancreatic cancer. Int J Oncol 1995;7: 825-829.
    • (1995) Int J Oncol , vol.7 , pp. 825-829
    • Yokoyama, M.1    Funatomi, H.2    Kobrin, M.S.3    Ebert, M.4    Friess, H.5    Büchler, M.W.6    Korc, M.7
  • 113
    • 0031787342 scopus 로고    scopus 로고
    • Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice
    • Wagner M, Luhrs H, Kloppel G, Adler G, Schmid RM: Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice. Gastroenterology 1998;115:1254-1262.
    • (1998) Gastroenterology , vol.115 , pp. 1254-1262
    • Wagner, M.1    Luhrs, H.2    Kloppel, G.3    Adler, G.4    Schmid, R.M.5
  • 114
    • 0030483560 scopus 로고    scopus 로고
    • Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum
    • Wagner M, Cao T, Lopez ME, Hope C, van Nostrand K, Kobrin MS, Fan HU, Büchler MW, Korc M: Expression of a truncated EGF receptor is associated with inhibition of pancreatic cancer cell growth and enhanced sensitivity to cisplatinum. Int J Cancer 1996;68: 782-787.
    • (1996) Int J Cancer , vol.68 , pp. 782-787
    • Wagner, M.1    Cao, T.2    Lopez, M.E.3    Hope, C.4    Van Nostrand, K.5    Kobrin, M.S.6    Fan, H.U.7    Büchler, M.W.8    Korc, M.9
  • 115
    • 0030824603 scopus 로고    scopus 로고
    • Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: Evidence for autocrine and paracrine actions
    • Kornmann M, Ishiwata T, Beger HG, Korc M: Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: Evidence for autocrine and paracrine actions. Oncogene 1997; 15:1417-1424.
    • (1997) Oncogene , vol.15 , pp. 1417-1424
    • Kornmann, M.1    Ishiwata, T.2    Beger, H.G.3    Korc, M.4
  • 117
    • 0032213027 scopus 로고    scopus 로고
    • The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
    • Kleeff J, Ishiwata T, Kumbasar A, Friess H, Büchler MW, Lander AD, Korc M: The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest 1998;102:1662-1673.
    • (1998) J Clin Invest , vol.102 , pp. 1662-1673
    • Kleeff, J.1    Ishiwata, T.2    Kumbasar, A.3    Friess, H.4    Büchler, M.W.5    Lander, A.D.6    Korc, M.7
  • 118
    • 0031872092 scopus 로고    scopus 로고
    • Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer
    • Ishiwata T, Friess H, Büchler MW, Lopez ME, Korc M: Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer. Am J Pathol 1998; 153:213-222.
    • (1998) Am J Pathol , vol.153 , pp. 213-222
    • Ishiwata, T.1    Friess, H.2    Büchler, M.W.3    Lopez, M.E.4    Korc, M.5
  • 119
    • 0031921301 scopus 로고    scopus 로고
    • Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo
    • Wagner M, Lopez ME, Cahn M, Korc M: Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo. Gastroenterology 1998;114:798-807.
    • (1998) Gastroenterology , vol.114 , pp. 798-807
    • Wagner, M.1    Lopez, M.E.2    Cahn, M.3    Korc, M.4
  • 121
    • 0031577571 scopus 로고    scopus 로고
    • Smad 1 and Smad 5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
    • Yamamoto N, Akiyama S, Katagiri T, Namiki M, Kurokawa T, Suda T: Smad 1 and Smad 5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem Biophys Res Commun 1997;238:574-580.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 574-580
    • Yamamoto, N.1    Akiyama, S.2    Katagiri, T.3    Namiki, M.4    Kurokawa, T.5    Suda, T.6
  • 123
    • 0031005355 scopus 로고    scopus 로고
    • Differential localization of transforming growth factor-β isoforms in human gastric mucosa and overexpression in gastric carcinoma
    • Naef M, Ishiwata T, Friess H, Büchler MW, Gold LI, Korc M: Differential localization of transforming growth factor-β isoforms in human gastric mucosa and overexpression in gastric carcinoma. Int J Cancer 1997;71:131-137.
    • (1997) Int J Cancer , vol.71 , pp. 131-137
    • Naef, M.1    Ishiwata, T.2    Friess, H.3    Büchler, M.W.4    Gold, L.I.5    Korc, M.6
  • 124
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor-β isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Büchler M, Ebert M, Beger HG, Gold LI, Korc M: Enhanced expression of transforming growth factor-β isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 1993;105: 1846-1856.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Büchler, M.3    Ebert, M.4    Beger, H.G.5    Gold, L.I.6    Korc, M.7
  • 125
    • 0029810920 scopus 로고    scopus 로고
    • Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
    • Baldwin RL, Friess H, Yokoyama M, Lopez ME, Kobrin MS, Büchler MW, Korc M: Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition. Int J Cancer 1996;67: 283-288.
    • (1996) Int J Cancer , vol.67 , pp. 283-288
    • Baldwin, R.L.1    Friess, H.2    Yokoyama, M.3    Lopez, M.E.4    Kobrin, M.S.5    Büchler, M.W.6    Korc, M.7
  • 126
  • 127
    • 0030612484 scopus 로고    scopus 로고
    • Induction of p21waf1 expression and growth inhibition by transforming growth factor-β involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells
    • Grau AM, Zhang L, Wang W, Ruan S, Evans DB, Abbruzzese JL, Zhang W, Chiao PJ: Induction of p21waf1 expression and growth inhibition by transforming growth factor-β involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res 1997;57:3929-3934.
    • (1997) Cancer Res , vol.57 , pp. 3929-3934
    • Grau, A.M.1    Zhang, L.2    Wang, W.3    Ruan, S.4    Evans, D.B.5    Abbruzzese, J.L.6    Zhang, W.7    Chiao, P.J.8
  • 129
    • 0030827414 scopus 로고    scopus 로고
    • Presence of two signaling TGF-β receptors in human pancreatic cancer correlates with advanced tumor stage
    • Lu Z, Friess H, Graber HU, Guo X, Schilling M, Zimmermann A, Korc M, Büchler MW: Presence of two signaling TGF-β receptors in human pancreatic cancer correlates with advanced tumor stage. Dig Dis Sci 1997;42: 2054-2063.
    • (1997) Dig Dis Sci , vol.42 , pp. 2054-2063
    • Lu, Z.1    Friess, H.2    Graber, H.U.3    Guo, X.4    Schilling, M.5    Zimmermann, A.6    Korc, M.7    Büchler, M.W.8
  • 130
    • 0031694080 scopus 로고    scopus 로고
    • Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer
    • Wagner M, Kleeff J, Lopez ME, Bockman I, Massaque J, Korc M: Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer. Int J Cancer 1998; 78:255-260.
    • (1998) Int J Cancer , vol.78 , pp. 255-260
    • Wagner, M.1    Kleeff, J.2    Lopez, M.E.3    Bockman, I.4    Massaque, J.5    Korc, M.6
  • 131
    • 0031561324 scopus 로고    scopus 로고
    • Signal transduction. Feedback from inhibitory SMADs
    • Whitman M: Signal transduction. Feedback from inhibitory SMADs. Nature 1997;389: 549-551.
    • (1997) Nature , vol.389 , pp. 549-551
    • Whitman, M.1
  • 134
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna G, Hata A, Hemmati-Brivanlou A, Massague J: Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 1996;383:832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 136
    • 0034648528 scopus 로고    scopus 로고
    • 1 represses proliferation of pancreatic carcinoma cells which correlates with Smad 4-independent inhibition of ERK activation
    • 1 represses proliferation of pancreatic carcinoma cells which correlates with Smad 4-independent inhibition of ERK activation. Oncogene 2000;19:4531-4541.
    • (2000) Oncogene , vol.19 , pp. 4531-4541
    • Giehl, K.1    Seidel, B.2    Gierschik, P.3    Adler, G.4    Menke, A.5
  • 137
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor-β receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE: Genetic alterations of the transforming growth factor-β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998;58:5329-5332.
    • (1998) Cancer Res , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 139
    • 0028785602 scopus 로고
    • A transforming growth factor-β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability
    • Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J, Park K: A transforming growth factor-β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995;55:5545-5547.
    • (1995) Cancer Res , vol.55 , pp. 5545-5547
    • Myeroff, L.L.1    Parsons, R.2    Kim, S.J.3    Hedrick, L.4    Cho, K.R.5    Orth, K.6    Mathis, M.7    Kinzler, K.W.8    Lutterbaugh, J.9    Park, K.10
  • 140
    • 0031893470 scopus 로고    scopus 로고
    • Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations
    • Iacopetta BJ, Welch J, Soong R, House AK, Zhou XP, Hamelin R: Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations. J Pathol 1998;184:390-395.
    • (1998) J Pathol , vol.184 , pp. 390-395
    • Iacopetta, B.J.1    Welch, J.2    Soong, R.3    House, A.K.4    Zhou, X.P.5    Hamelin, R.6
  • 141
    • 0032527902 scopus 로고    scopus 로고
    • Mutation of the type II transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas
    • Grady WM, Rajput A, Myeroff L, Liu DF, Kwon K, Willis J, Markowitz S: Mutation of the type II transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res 1998;58:3101-3104.
    • (1998) Cancer Res , vol.58 , pp. 3101-3104
    • Grady, W.M.1    Rajput, A.2    Myeroff, L.3    Liu, D.F.4    Kwon, K.5    Willis, J.6    Markowitz, S.7
  • 142
    • 0033573974 scopus 로고    scopus 로고
    • Smad 6 suppresses TGF-β-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer
    • Kleeff J, Maruyama H, Friess H, Büchler MW, Falb D, Korc M: Smad 6 suppresses TGF-β-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. Biochem Biophys Res Commun 1999;255:268-273.
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 268-273
    • Kleeff, J.1    Maruyama, H.2    Friess, H.3    Büchler, M.W.4    Falb, D.5    Korc, M.6
  • 144
    • 0031846251 scopus 로고    scopus 로고
    • Concomitant overexpression of activin/inhibin β subunits and their receptors in human pancreatic cancer
    • Kleeff J, Ishiwata T, Friess H, Büchler MW, Korc M: Concomitant overexpression of activin/inhibin β subunits and their receptors in human pancreatic cancer. Int J Cancer 1998; 77:860-868.
    • (1998) Int J Cancer , vol.77 , pp. 860-868
    • Kleeff, J.1    Ishiwata, T.2    Friess, H.3    Büchler, M.W.4    Korc, M.5
  • 145
    • 0032908128 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo
    • Kleeff J, Maruyama H, Ishiwata T, Sawhney H, Friess H, Büchler MW, Korc M: Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology 1999;116:1202-1216.
    • (1999) Gastroenterology , vol.116 , pp. 1202-1216
    • Kleeff, J.1    Maruyama, H.2    Ishiwata, T.3    Sawhney, H.4    Friess, H.5    Büchler, M.W.6    Korc, M.7
  • 147
    • 0029027526 scopus 로고
    • Nerve growth factor stimulates clonal growth of human lung cancer cell lines and a human glioblastoma cell line expressing high-affinity nerve growth factor binding sites involving tyrosine kinase signaling
    • Oelmann E, Sreter L, Schuller I, Serve H, Koenigsmann M, Wiedenmann B, Oberberg D, Reufi B, Thiel E, Berdel WE: Nerve growth factor stimulates clonal growth of human lung cancer cell lines and a human glioblastoma cell line expressing high-affinity nerve growth factor binding sites involving tyrosine kinase signaling. Cancer Res 1995; 55:2212-2219.
    • (1995) Cancer Res , vol.55 , pp. 2212-2219
    • Oelmann, E.1    Sreter, L.2    Schuller, I.3    Serve, H.4    Koenigsmann, M.5    Wiedenmann, B.6    Oberberg, D.7    Reufi, B.8    Thiel, E.9    Berdel, W.E.10
  • 148
    • 0031054680 scopus 로고    scopus 로고
    • Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells
    • Geldof AA, De Kleijn MA, Rao BR, Newling DW: Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells. J Cancer Res Clin Oncol 1997; 123:107-112.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 107-112
    • Geldof, A.A.1    De Kleijn, M.A.2    Rao, B.R.3    Newling, D.W.4
  • 149
    • 0026018821 scopus 로고
    • Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications
    • Pour PM, Egami H, Takiyama Y: Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications. Gastroenterology 1991;100: 529-536.
    • (1991) Gastroenterology , vol.100 , pp. 529-536
    • Pour, P.M.1    Egami, H.2    Takiyama, Y.3
  • 150
    • 0023626809 scopus 로고
    • Cancer of the pancreas. 50 years of surgery
    • Gudjonsson B: Cancer of the pancreas. 50 years of surgery. Cancer 1987;60:2284-2303.
    • (1987) Cancer , vol.60 , pp. 2284-2303
    • Gudjonsson, B.1
  • 151
    • 0006634967 scopus 로고    scopus 로고
    • Morphology of pancreatic cancer: Involvement of nerves
    • Beger HG, Büchler MW, Schoenberg M (eds): Ulm, Universitätsverlag Ulm GmbH
    • Bookman DE, Büchler MW, Beger HG: Morphology of pancreatic cancer: Involvement of nerves; in Beger HG, Büchler MW, Schoenberg M (eds): Cancer of the Pancreas. Ulm, Universitätsverlag Ulm GmbH, 1996, pp 99-108.
    • (1996) Cancer of the Pancreas , pp. 99-108
    • Bookman, D.E.1    Büchler, M.W.2    Beger, H.G.3
  • 152
    • 0032792960 scopus 로고    scopus 로고
    • Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer
    • Zhu Z, Friess H, diMola FF, Zimmermann A, Graber HU, Korc M, Büchler MW: Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol 1999;17:2419-2428.
    • (1999) J Clin Oncol , vol.17 , pp. 2419-2428
    • Zhu, Z.1    Friess, H.2    DiMola, F.F.3    Zimmermann, A.4    Graber, H.U.5    Korc, M.6    Büchler, M.W.7
  • 153
    • 0035132668 scopus 로고    scopus 로고
    • Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells
    • Zhu Z, Wang L, Kleeff J, Bogardus T, Korc M, Büchler MW, Friess H: Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells. Clin Cancer Res 2001;7:105-112.
    • (2001) Clin Cancer Res , vol.7 , pp. 105-112
    • Zhu, Z.1    Wang, L.2    Kleeff, J.3    Bogardus, T.4    Korc, M.5    Büchler, M.W.6    Friess, H.7
  • 154
    • 0029146793 scopus 로고
    • Induction of platelet-derived growth factor a and B chains and overexpression of their receptors in human pancreatic cancer
    • Ebert M, Yokoyama M, Friess H, Kobrin MS, Büchler MW, Korc M: Induction of platelet-derived growth factor A and B chains and overexpression of their receptors in human pancreatic cancer. Int J Cancer 1995;62:529-535.
    • (1995) Int J Cancer , vol.62 , pp. 529-535
    • Ebert, M.1    Yokoyama, M.2    Friess, H.3    Kobrin, M.S.4    Büchler, M.W.5    Korc, M.6
  • 155
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M: Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles. Cancer Res 1995;55:2007-2011.
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 156
    • 0028793112 scopus 로고
    • Insulin-like growth factors and breast cancer
    • Lee AV, Yee D: Insulin-like growth factors and breast cancer. Biomed Pharmacother 1995;49:415-421.
    • (1995) Biomed Pharmacother , vol.49 , pp. 415-421
    • Lee, A.V.1    Yee, D.2
  • 158
    • 0024146676 scopus 로고
    • Molecular aspects of insulin-like growth factors, their binding proteins and receptors
    • Roberts CT Jr, Leroith D: Molecular aspects of insulin-like growth factors, their binding proteins and receptors. Baillieres Clin Endocrinol Metab 1988;2:1069-1085.
    • (1988) Baillieres Clin Endocrinol Metab , vol.2 , pp. 1069-1085
    • Roberts Jr., C.T.1    Leroith, D.2
  • 159
    • 0028279242 scopus 로고
    • Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins 1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries
    • el-Roeiy A, Chen X, Roberts VJ, Shimasakai S, Ling N, LeRoith D, Roberts CT Jr, Yen SS: Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins 1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries. J Clin Endocrinol Metab 1994;78:1488-1496.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1488-1496
    • El-Roeiy, A.1    Chen, X.2    Roberts, V.J.3    Shimasakai, S.4    Ling, N.5    LeRoith, D.6    Roberts Jr., C.T.7    Yen, S.S.8
  • 160
    • 0025017059 scopus 로고
    • Insulin-like growth factor I and transforming growth factor-α as autocrine growth factors in human pancreatic cancer cell growth
    • Ohmura E, Okada M, Onoda N, Kamiya Y, Murakami H, Tsushima T, Shizume K: Insulin-like growth factor I and transforming growth factor-α as autocrine growth factors in human pancreatic cancer cell growth. Cancer Res 1990;50:103-107.
    • (1990) Cancer Res , vol.50 , pp. 103-107
    • Ohmura, E.1    Okada, M.2    Onoda, N.3    Kamiya, Y.4    Murakami, H.5    Tsushima, T.6    Shizume, K.7
  • 161
    • 0030728566 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factors (IGF-I and IGF-II) and heir binding protein (IGFBP-3) are not elevated in pancreatic cancer
    • Evans JD, Eggo MC, Donovan IA, Bramhall SR, Neoptolemos JP: Serum levels of insulin-like growth factors (IGF-I and IGF-II) and heir binding protein (IGFBP-3) are not elevated in pancreatic cancer. Int J Pancreatol 1997;22:95-100.
    • (1997) Int J Pancreatol , vol.22 , pp. 95-100
    • Evans, J.D.1    Eggo, M.C.2    Donovan, I.A.3    Bramhall, S.R.4    Neoptolemos, J.P.5
  • 162
    • 0030816910 scopus 로고    scopus 로고
    • Altered expression of insulin-like growth factor II receptor in human pancreatic cancer
    • Ishiwata T, Bergmann U, Kornmann M, Lopez M, Beger HG, Korc M: Altered expression of insulin-like growth factor II receptor in human pancreatic cancer. Pancreas 1997; 15:367-373.
    • (1997) Pancreas , vol.15 , pp. 367-373
    • Ishiwata, T.1    Bergmann, U.2    Kornmann, M.3    Lopez, M.4    Beger, H.G.5    Korc, M.6


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