Mutation of the transforming growth factor-β type II receptor gene in right-sided colorectal cancer: Relationship to clinicopathological features and genetic alterations

Journal of Pathology

Volumn 184, Issue 4, 1998, Pages 390-395

  Iacopetta, Barry J ^a   Welch, John ^a   Soong, Richie ^a   House, Anthony K ^a   Zhou, Xiao Ping ^b   Hamelin, Richard ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b FONDATION JEAN DAUSSET CEPH   (France)

Author keywords

Colorectal carcinoma; p53; Replication error (RER); Transforming growth factor

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; BASE PAIRING; CELL DIFFERENTIATION; COLORECTAL CANCER; EPITHELIUM CELL; GENE DELETION; GENE MUTATION; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR GENE; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AGED; COLORECTAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031893470     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199804)184:4<390::AID-PATH1230>3.0.CO;2-Q     Document Type: Article

References (39)

1. Massague J. The transforming growth factor-β family. Annu Rev Cell Biol 1990; 6: 597-641.
2. Roberts A, Sporn M. Peptide growth factors and their receptors. In: Sporn M, Roberts A, eds. Handbook of Experimental Pharmacology. Heidelberg: Springer-Verlag, 1990; 419-472.
3. Wang C, Eshleman J, Willson J, Markowitz S. TGF-β and substrate release are both inducers of apoptosis in a human colon adenoma cell line. Cancer Res 1995; 55: 5101-5105.
4. Avery A, Paraskeva C, Hall P, Flanders K, Sporn M, Moorghen M. TGF-β expression in the human colon: differential immunostaining along crypt epithelium. Br J Cancer 1993; 68: 137-139.
5. Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995; 268: 1336-1338.
6. Wang J, Sun L, Myeroff L, et al. Demonstration that mutation of the type II transforming growth factor-β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J Biol Chem 1995; 270: 22 044-22 049.
7. Fearon E, Vogelstein B. A genetic model for colorectal tumourigenesis. Cell 1990; 61: 759-767.
8. Parsons R, Myeroff L, Liu B, et al. Microsatellie instability and mutations of the transforming growth factor-β type II receptor gene in colorectal cancer. Cancer Res 1995; 55: 5548-5550.
9. Eshleman J, Markowitz S. Mismatch repair defects in human carcinogenesis. Hum Mol Genet 1996; 5: 1489-1494.
10. Liu B, Nicolaides N, Markowitz S, et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet 1995; 9: 48-55.
11. Akiyama Y, Iwanaga R, Ishikawa T, et al. Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer 1996; 78: 2478-2484.
12. Myeroff L, Parsons R, Kim S, et al. A transforming growth factor-β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995; 55: 5545-5547.
13. Lothe R, Peltomaki P, Meling G, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993; 53: 5849-5852.
14. Kim H, Jen J, Vogelstein B, Hamilton S. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994; 145: 148-156.
15. Ionov Y, Peinado M, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 1993; 363: 558-561.
16. Thibodeau S, Bren A, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-819.
17. Lu S, Akiyama Y, Nagasaki H, Saitoh K, Yuasa Y. Mutations of the transforming growth factor-β type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. Biochim Biophys Res Commun 1995; 216: 452-457.
18. Souza R, Lei J, Yin J, et al. A transforming growth factor-β1 receptor type II mutation in ulcerative colitis-associated neoplasms. Gastroenterology 1997; 112: 40-45.
19. Dix B, Robbins P, Carrello S, House A, Iacopetta B. Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas. Br J Cancer 1994; 70: 585-590.
20. Soong R, Grieu F, Robbins P, et al. p53 alterations are associated with improved prognosis in distal colonie carcinomas. Clin Cancer Res 1997; 3: 1405-1411.
21. Dix B, Robbins P, Soong R, Jenner D, House A, Iacopetta B. The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int J Cancer 1994; 59: 747-751.
22. Soong R, Iacopetta B. A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors. Mod Pathol 1997; 12: 252-258.
23. Hoang J, Cottu P, Thuille B, Salmon R, Thomas G, Hamelin R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res 1997; 57: 300-303.
24. Zhou X-P, Hoang J-M, Cottu P, Thomas G, Hamelin R. Allelic profiles of mononucleotide repeats in microsatellites in control individuals and in colorectal tumours with and without replication errors. Oncogene 1997; 15: 1713-1718.
25. Shibata D, Peinado M, Ionov Y, Malkhosyan S, Perucho M. Genomic instability in repeated sequences is an early somatic event in colorectal tumourigenesis that persists after transformation. Nature Genet 1994; 6: 273-281.
26. Bodmer W, Bishop T, Karran P. Genetic steps in colorectal cancer. Nuture Genet 1994; 6: 217-219.
27. Aaltonen L, Peltomaki P, Leach F, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260: 812-816.
28. Heinen C, Richardson D, White R, Groden J. Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein. Cancer Res 1995; 55: 4797-4799.
29. Muta H, Noguchi M, Perucho M, et al. Clinical implications of microsatellite instability in colorectal cancers. Cancer 1996; 77: 265-270.
30. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996; 111: 307-317.
31. Bocker T, Schlegel J, Kullmann F, et al. Genomic instability in colorectal carcinomas: comparison of different evaluation methods and their biological significance. J Pathol 1996; 179: 15-19.
32. Cottu P, Muzeau F, Estreicher A, et al. Inverse correlation between RER + status and p53 mutation in colorectal cancer cell lines. Oncogene 1996; 13: 2727-2730.
33. Kahlenberg M, Stoler D, Basik M, Petrelli N, Rodriguez-Bigas M, Anderson G. p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers. J Natl Cancer Inst 1996; 88: 1665-1670.
34. Ilyas M, Tomlinson I, Novelli M, Hanby A, Bodmer W, Talbot I. Clinicopathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability. J Pathol 1996; 179: 370-375.
35. Huang J, Papadopoulos N, McKinley A, et al. APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci U.S.A. 1996; 93: 9049-9054.
36. Kinzler K, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159-170.
37. Souza R, Appel R, Yin J, et al. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nature Genet 1996; 14: 255-257.
38. Malkhosyan S, Rampino N, Yamamoto H, et al. Frameshift mutator mutations. Nature 1996; 382: 499-500.
39. Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype 1997; 275: 967-969.