Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

Blood

Volumn 98, Issue 9, 2001, Pages 2800-2807

  Jones, Dylan T ^a   Ganeshaguru, Kanagasabai ^a   Virchis, Andres E ^a   Folarin, Najeem I ^a   Lowdell, Mark W ^a   Mehta, Atul B ^a   Grant Prentice, H ^a   Victor Hoffbrand, A ^a   Gitendra Wickremasinghe, R ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CH 11; CHLORAMBUCIL; CYTOTOXIC AGENT; FAS ANTIBODY; FAS ANTIGEN; FAS LIGAND; FLUDARABINE; GLUTAMINE; MESSENGER RNA; PENICILLIN G; STREPTOMYCIN; ZB 4;

APOPTOSIS; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GAMMA RADIATION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; RNA TRANSLATION; SIGNAL TRANSDUCTION;

EID: 0035525772     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.9.2800     Document Type: Article

References (52)

1. Vaux DL, Haecker G, Strasser A. An evolutionary perspective on apoptosis. Cell. 1994;76:777-779.
2. Thornberry NA. Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316.
3. Wickremasinghe RG, Hoffbrand AV. Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies. Blood. 1999;93:3587-3600.
4. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305-1308.
5. Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407:770-776.
6. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993;53:3976-3985.
7. Datta R, Banach D, Kojima H, et al. CPP32 protease in apoptosis induced by 1-β-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood. 1996;88:1936-1943.
8. Friesen C. Fulda S, Debatin K-M. Cytotoxic drugs and the CD95 pathway. Leukemia. 1999;13:1854-1858.
9. Friesen C, Herr I, Krammer PH, Debatin KM. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med. 1996;2:574-577.
10. Fulda S, Strauss G, Meyer E, Debatin K-M. Functional CD95 ligand and CD95 death inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells. Blood. 2000;95:301-308.
11. Posovszky C, Friesen C, Herr I, Debatin K-M. Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis. Leukemia. 1999;13:400-409.
12. Muller M, Strand S, Hug H, et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest. 1997;99:403-413.
13. Muller M, Wilder S, Bannasch D, et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med. 1998;188:2033-2045.
14. Herr I, Wilhelm D, Bohler T, Angel P, Debatin K-M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 1997;16:6200-6208.
15. Fulda S, Sieverts H, Friesen C, Herr I, Debatin K-M. The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res. 1997;57:3823-3829.
16. Mizutani Y, Okada Y, Yoshida O, Fukumoto M, Bonavida B. Doxorubicin sensitizes human bladder carcinoma cells to Fas-mediated cytotoxicity. Cancer. 1997;79:1180-1189.
17. Kolbus A, Herr I, Schreiber M, Debatin K-M, Wagner EF, Angel P. c-jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol. 2000;20:575-582.
18. McGahon AJ, Costa Pereira AP, Daly L, Cotter TG. Chemotherapeutic drug-induced apoptosis in human leukemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system. Br J Haematol. 1998;101:539-547.
19. Gamen S, Anel A, Lassiera P, et al. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase 3 in a Fas-independent way. FEBS Lett. 1997;417:360-364.
20. Richardson DS, Allen PD, Kelsey SM, Newland AC. Inhibition of Fas/Fas-ligand does not block chemotherapy-induced apoptosis in drug sensitive and resistant cells. Adv Exp Med Biol. 1999;457:259-266.
21. Villunger A, Egle A, Kos M, et al. Drug-induced apoptosis is associated with enhanced Fas(Apo-1/CD95) ligand expression but occurs independently of Fas(Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells. Cancer Res. 1997;57:3331-3334.
22. Eischen CM, Kottke TJ, Martins LM, et al. Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interaction. Blood. 1997;90:935-943.
23. Tolomeo M, Dusonchet L, Meli M, et al. The CD95/CD95 ligand system is not the major effector in anticancer drug-mediated apoptosis. Cell Death Differ. 1998;5:735-742.
24. Landowski TH, Shain KH, Oshiro MM, Buyuksal I, Painter JS, Dalton WS. Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation. Blood. 1999;94:265-274.
25. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94:481-490.
26. Li H, Zhu H, Xu C-J, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491-501.
27. Prokocimer M, Rotter V. Structure and function of p53 in normal cells and their alterations in cancer cells: projections of the hematologic cell lineages. Blood. 1994;84:2391-2411.
28. Virchis AE, Ganeshaguru K, Hoffbrand AV, Mehta AB, Prentice HG, Wickremasinghe RG. A role for c-ABL tyrosine kinase in p53 up-regulation and apoptosis in B-CLL cells exposed to chlorambucil [abstract]. Blood. 2000;96:82.
29. Owen-Schaub LB, Zhang W, Cusack JC, et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol. 1995;15:3032-3041.
30. Fukazawa T, Fujiwara T, Morimoto Y, et al. Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induction by the wild-type p53 gene transfer in human cancer cells. Oncogene. 1999;18:2189-2199.
31. Huebner A-O, Zornig M, Lyon D, Suda T, Nagata S, Evan GI. Requirement for the CD95 receptor-ligand pathway in c-myc-induced apoptosis. Science. 1997;278:1305-1309.
32. Panayiotidis P, Ganeshaguru K, Foroni L, Hoffbrand AV. Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia. 1995;9:1227-1232.
33. Silber R, Degar B, Costin D, et al. Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine and camptothecin analogs. Blood. 1994;84:3440-3446.
34. Cotter TG, Martin SJ. Techniques in apoptosis: a user's guide. London, United Kingdom: Portland Press; 1996.
35. Pieters R, Loonen AH, Huismans DR, et al. In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions. Blood. 1990;76:2327-2336.
36. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by PI staining and flow cytometry. J Immunol Methods. 1991;139:271-279.
37. Zamai L, Secchiero P, Pierpaoli S, et al. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis. Blood. 2000;95:3716-3724.
38. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
39. Stennicke HR, Devereaux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS. Caspase 9 can be activated without proteolytic processing. J Biol Chem. 1999;274:8359-8362.
40. King D, Pringle JH, Hutchinson M, Cohen GM. Processing and activation of caspases-3 and -7 and -8 but not caspase-2 in the induction of apoptosis in B-chronic lymphocytic leukemia cells. Leukemia. 1998:12:1553-1560.
41. Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K. Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood. 1999;93:3053-3063.
42. Ferreira CG, Tolis C, Span SW, et al. Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Clin Cancer Res. 2000;6:203-212.
43. Micheau O, Solary E, Hammann A, Dimanche-Boitrel MT. Fas ligand-independent, FADD-mediated activation of the Fas pathway by anticancer drugs. J Biol Chem. 1999;274:7987-7992.
44. Pan G, Humke EW, Dixit VM. Activation of caspases triggered by cytochrome c in vitro. FEBS Lett. 1998;426:151-154.
45. Ferrari D, Stepczynska A, Los M, Wesselborg S, Schulze-Osthoff K. Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis. J Exp Med. 1998;188:979-984.
46. Ferreira CG, Span SW, Peters GJ, Kruyt FAE, Giaccone G. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res. 2000;60:7133-7141.
47. Engels IH, Stepczynska A, Stroh C, et al. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene. 2000;19:4563-4573.
48. Cantwell MJ, Kipps TJ. CD95 expression and apoptosis of chronic lymphocytic leukemia B cells. Blood. 1995;86(suppl 1):346.
49. Wang D, Freeman GJ, Levine H, Ritz J, Robertson MJ. Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies. Br J Haematol. 1997;97:409-417.
50. Williams JF, Petrus MJ, Wright JA. Fas-mediated lysis of chronic lymphocytic leukemia cells: roles of type I and type II cytokines and autologous FasL-expressing cells. Br J Haematol. 1999;107:99-105.
51. Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388:190-195.
52. Scaffidi C, Schmitz I, Krammer PH, Peter ME. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem. 1999;274:1541-1548.