Fas-mediated lysis of chronic lymphocytic leukaemia cells: Role of type I versus type II cytokines and autologous FasL-expressing T cells

British Journal of Haematology

Volumn 107, Issue 1, 1999, Pages 99-105

  Williams, Jonathan F ^a   Petrus, Matthew J ^a   Wright, Jacob A ^a   Husebekk, Anne ^b   Fellowes, Vicki ^a   Read, Elizabeth J ^b   Gress, Ronald E ^a   Fowler, Daniel H ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Apoptosis; Chronic lymphocytic leukaemia; Fas; IL 4; Th1 Th2 cytokines

Indexed keywords

ALPHA INTERFERON; FAS ANTIGEN; INTERLEUKIN 4;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CYTOKINE PRODUCTION; CYTOLYSIS; HUMAN; HUMAN CELL; IMMUNOREGULATION; INTERFERON PRODUCTION; PRIORITY JOURNAL;

ANTIGENS, CD95; APOPTOSIS; FAS LIGAND PROTEIN; HUMANS; INTERFERONS; INTERLEUKINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0032710091     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01670.x     Document Type: Article

References (31)

1. Aral, H., Gordon, D., Nabel, E.G. & Nabel, G.J. (1997) Gene transfer of Fas ligand induces tumor regression in vivo. Proceedings of the National Academy of Sciences of the United States of America, 94, 13862-13867.
2. Bucchner, S.A., Wernli, M., Harr, T., Hahn, S., Itin, P. & Erb, P. (1997) Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide. Journal of Clinical Investigation, 100, 2691-2696.
3. Carter, L.L. & Dutton, R.W. (1995) Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. Journal of Immunology, 155, 1028-1031.
4. Coney, L.R., Daniel, P.T., Sanborn, D., Dhein, J., Debatin, K.M., Krammer, P.H. & Zurawski, V.R., Jr (1994) Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression. International Journal of Cancer, 58, 562-567.
5. Cordone, I., Matutes, E. & Catovsky, D. (1992) Monoclonal antibody Ki-67 identifies B and T cells in cycle in chronic lymphocytic leukemia: correlation with disease activity. Leukemia, 6, 902-906.
6. Croft, M., Carter, L., Swain, S.L. & Dutton, R.W. (1994) Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. Journal of Experimental Medicine, 180, 1715-1728.
7. + T-cell subset in B-cell chronic lymphocytic leukaemia. British Journal of Harmatology, 104, 589-599.
8. Foote L.C., Howard, R.G., Marshak-Rothstehi, A. & Rothstein, T.L. (1996) IL-4 induces Fas resistance in B cells. Journal of Immunology, 157, 2749-2753.
9. Garrone, P., Neidhardt, E.M., Garcia, E., Galibert, L., van Kooten, C. & Banchereau, J. (1995) Fas ligation induces apoptosis of CD40-activated human B lymphocytes. Journal of Experimental Medicine, 182, 1265-1273.
10. Hanada, M., Delia, D., Aiello, A., Stadtmauer, E. & Reed, J.C. (1993) Bcl-2 gene hypermethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood, 82, 1829.
11. Jaattela, M., Benedict, M., Tewari, M., Shayman, J.A. & Dixit, V.M. (1995) Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene, 10, 2297-2305.
12. Kagi, D., Vignaux, F., Ledermann, B., Burki, K., Depraetere, V., Nagata, S., Hengartner, H. & Golstein, P. (1994) Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science, 265, 528-530.
13. Lagresle, C., Bella, C., Daniel, P.T., Krammer, P.H. & Defrance, T. (1995) Regulation of germinal center B-cell differentiation: role of the human APO-1/Fas (CD95) molecule. Journal of Immunology, 154, 5746-5756.
14. Manetti, R., Parronchi, P., Giudizi, M.G., Piccinni, M.P., Maggi, E., Trinchieri, G. & Romagnani, S. (1993) Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. Journal of Experimental Medicine, 177, 1199-1204.
15. Mu, X., Kay, N.E., Gosland, M.P. & Jennings, C.D. (1997) Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T-cells. British Journal of Haematology, 96, 733-735.
16. Osorio, L.M., Jondal, M. & Aguilar-Santelises, M. (1998) Regulation of B-CLL apoptosis through membrane receptors and Bcl-2 family proteins. Leukemia and Lymphoma, 30, 247-256.
17. Ozdemirli, M., el-Khatib, M., Foote, L.C., Wang, J.K., Marshak-Rothstein, A., Rothstein, T.L. & Ju, S.T. (1996) Fas (CD95)/Fas ligand interactions regulate antigen-specific, major histocompatibility complex-restricted T/B-cell proliferative responses. European Journal of Immunology, 26, 415-419.
18. Panayiotidis, P., Ganeshaguru, K., Foroni, L & Hoffbrand, A.V. (1995) Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia, 9, 1227-1232.
19. Panayiotidis, P., Ganeshaguru, K., Jabbar, S. & Hoffbrand, A.V, (1994) Alpha-interferon (α-IFN) protects B-chronic lymphocytic leukaemia cells from apoptotic cell death in vitro. British Journal of Haematology, 86, 169-173.
20. Ramsdell, F., Seaman, M.S., Miller, R.E., Picha, K.S., Kennedy, M.K. & Lynch, D.H. (1994) Differential ability of Th1 and Th2 T-cells to express Fas ligand and to undergo activation-induced cell death. International Immunology, 6, 1545-1553.
21. Rothstein, T.L., Wang, J.K., Panka, D.J., Foote, L.C., Wang, Z., Stanger, B., Cui, H., Ju. S.T. & Marshak-Rothstein, A. (1995) Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B-cells. Nature, 374, 163-165.
22. Rouvier, E., Luciani, M.F. & Golstein, P. (1993) Fas involvement in Ca(2+)-independent T-cell-mediated cytotoxicity. Journal of Experimental Medicine, 177, 195-200.
23. + T-cells secreting Th1 or Th2 cytokines. Immunity, 2, 271-279.
24. + T-cells from T-cell receptor transgenic mice. Journal of Experimental Medicine, 176, 1091-1098.
25. Takahashi, T., Tanaka, M., Brannan, C.L. Jenkins, N.A., Copeland, N.G., Suda, T. & Nagata, S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76, 969-976.
26. Thilenius, A.R., Braun, K. & Russell, J.H. (1997) Agonist antibody and Fas ligand mediate different sensitivity to death in the signalling pathways of Fas and cytoplasmic mutants. European Journal of Immunology 27, 1108-1114.
27. + lymphoid population capable of cliciting cytolysis against Fas-positive tumor cells. Journal of Immunology, 159, 2599-2605.
28. Wang, D., Freeman, G.J., Levine, H., Ritz, J. & Robertson, M.J. (1997) Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies. British Journal of Haematology, 97, 409-417.
29. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. & Nagata, S. (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature, 356, 314-317.
30. Wunderlich, J. & Shearer, G. (1992) Induction and measurement of cytotoxic T lymphocyte activity. Current Protocols in Immunology (ed. by J. E. Coligan, A. M. Kruisbeek, D. H. Marguilies and E. Shevach). pp. 3.11.14-13.11.17. John Wiley and Sons, New York.
31. Younes, A., Snell, V., Consoli, U., Clodi, K., Zhao, S., Palmer, J.L., Thomas, E.K., Armitage, R.J. & Andreeff, M. (1998) Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia. British Journal of Haematology, 100, 135-141.