The Id proteins: Targets for inhibiting tumor cells and their blood supply

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1551, Issue 2, 2001, Pages

  Benezra, Robert ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Angiogenesis; Cell cycle; Differentiation; Helix loop helix; Tumor

Indexed keywords

HELIX LOOP HELIX PROTEIN;

ANGIOGENESIS; BLOOD VESSEL; CANCER CELL; CANCER THERAPY; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA BINDING; HUMAN; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; TARGET CELL; TUMOR CELL; TUMOR GROWTH; VASCULARIZATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE TARGETING; GENE THERAPY; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MODELS, MOLECULAR; NEOPLASMS; PROTEIN ISOFORMS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035478613     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-419X(01)00028-2     Document Type: Review

References (74)

1. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
2. Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis
3. Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis
4. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal
5. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
6. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer
7. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
8. Id proteins Id1 and 1d2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
9. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene
10. Overexpression of Id protein inhibits the muscle differentiation program: In vivo association of Id with E2A proteins
11. HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id
12. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist
13. Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression
14. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
15. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
16. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
17. MIDA1, a protein associated with Id, regulates cell growth
18. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors
19. Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding
20. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes
21. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
22. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
23. Myocardial activation of the human cardiac α-actin promoter by helix-loop-helix proteins
24. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: Implications for B lymphoid development
25. Functional characterization of the developmentally controlled immunoglobulin kappa 3′ enchancer: Regulation by Id, a repressor of helix-loop-helix transcription factors
26. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines
27. Pancreatic B-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins
28. Inhibition of muscle-specific gene expression by Id3: Requirement of the C-terminal region of the protein for stable expression and function
29. Inhibition of myeloid differentiation by the helix-loop-helix protein Id
30. Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells
31. The helix-loop-helix protein Id inhibits differentiation of murine erythroleukemia cells
32. Inhibition of an erythroid differentiation switch by the helix-loop-helix protein Id1
33. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1
34. Muscle cell differentiation is inhibited by the helix-loop-helix protein Id3
35. Regulation of cell differentiation in C2C12 myoblasts by the Id3 helix-loop-helix protein
36. Id3 prevents differentiation of preadipose cells
37. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells
38. Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells
39. Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse
40. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation
41. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
42. Neural crest specification regulated by the helix-loop-helix repressor Id2
43. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
44. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
45. Impaired immune responses and B cell proliferation in mice lacking the Id3 gene
46. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
47. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
48. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors
49. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism
50. Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppressor protein to regulate cortical neurogenesis
51. Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice
52. Id proteins control growth induction in mammalian cells
53. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
54. Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
55. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma
56. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells
57. The helix-loop-helix transcription factor, Id-1, is overexpressed in medullary thyroid cancer
58. Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis
59. Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function
60. Forced expression of Id-1 in the adult mouse small intestinal epithelium is associated with development of adenomas
61. Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer
62. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
63. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
64. Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice
65. Transcription of the dominant negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate early response gene Egr-1
66. A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes
67. Granulocyte colony-stimulating factor induces Egr-1 up-regulation through interaction of serum response element-binding proteins
68. Integration of MAP kinase signal transduction pathways at the serum response element
69. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
70. Genes expressed in human tumor endothelium
71. Conformational changes of the Tet repressor induced by tetracycline trapping
72. Effects of ligand binding on the association properties and conformation in solution of retinoic acid receptors RXR and RAR
73. Antisense oligonucleotides as therapeutic agents
74. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance