IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98- kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 2081-2086

  Gadina, Massimo ^a   Sudarshan, Chitra ^a   O'Shea, John J ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MSC 1820 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; GLYCOPROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ARTICLE; CONTROLLED STUDY; DEGLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPRECIPITATION; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; GRB2 ADAPTOR PROTEIN; HUMANS; INTERLEUKIN-2; INTERLEUKIN-4; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 3; KILLER CELLS, NATURAL; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MOLECULAR WEIGHT; NEURAL CELL ADHESION MOLECULE L1; NEURAL CELL ADHESION MOLECULES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RECEPTORS, IMMUNOLOGIC; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

EID: 0033558095     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Taniguchi, T., and Y. Minami. 1993. The IL-2/IL-2 receptor system: a current overview. Cell 73:5.
2. Gomez, J., A. Gonzalez, C. Martinez-A. and A. Rebollo. 1998. IL-2-induced cellular events. Crit. Rev. Immunol. 18:185.
3. Johnston, J. A., M. Kawamura, R. A. Kirken, Y. Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
4. O'Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7:1.
5. Chen, M., A. Cheng, Y. Q. Chen, A. Hymel, E. P. Hanson, L. Kimmel, Y. Minami, T. Taniguchi, P. S. Changelian, and J. J. O'Shea. 1997. The aminotermius of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc. Natl. Acad. Sci. USA 94:6910.
6. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
7. Fuji, H., Y. Nakagawa, U. Schindler, A. Kawahara, H. Mori, F. Gouilleux, B. Groner, J. N. Ihle, Y. Minami, T. Miyazaki, et al. 1995. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor β chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92:5482.
8. Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and S. L. McKnight. 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321.
9. Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, et al. 1995. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92:8705.
10. Lin, J. X., T. S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331.
11. Burns, L. A., L. M. Karnitz, S. L. Sutor, and R. T. Abraham. 1993. Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes. J. Biol. Chem. 268:17659.
12. Ravichandran, K. S., and S. J. Burakoff. 1994. The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. J. Biol. Chem. 269: 1599.
13. Merida, I., E. Diez, and G. N. Gaulton. 1991. IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. J. Immunol. 147:2202.
14. Ahmed, N. N., H. L. Grimes, A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94:3627.
15. Karnitz, L. M., L. A. Burns, S. L. Sutor, J. Blenis, and R. T. Abraham. 1995. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cell. Biol. 15:3049.
16. Johnston, J. A., L. M. Wang, E. P. Hanson, X. J. Sun, M. F. White, S. A. Oakes, J. H. Pierce, and J. J. O'Shea. 1995. Interleukins 2,4,7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. J. Biol. Chem. 270:28527.
17. Truitt, K. E., G. B. Mills, C. W. Turck, and J. B. Imboden. 1994. SH2-dependent association of phosphatidylinositol 3′-kinase 85-kDa regulatory subunit with the interleukin-2 receptor β chain. J. Biol. Chem. 269:5937.
18. Li, W., R. Nishimura, A. Kashishian, A. G. Batzer, W. J. Kim, J. A. Cooper, and J. Schlessinger. 1994. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol. 14:509.
19. Bennett, A. M., T. L. Tang, S. Sugimoto, C. T. Walsh, and B. G. Neel. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras. Proc. Natl. Acad. Sci. USA 91:7335.
20. c chain for Janus kinase activation leading to T cell proliferation. Proc. Natl. Acad. Sci. USA 94:1878.
21. Adachi, M., M. Ishino, T. Torigoe, Y. Minami, T. Matozaki, T. Miyazaki, T. Taniguchi, Y. Hinoda, and K. Imai. 1997. Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor β chain. Oncogene 14:1629.
22. Gadina, M., L. M. Stancato, C. M. Bacon, A. C. Larner, and J. J. O'Shea. 1998. Cutting Edge: Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. J. Immunol. 160:4657.
23. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
24. Kharitonenkov, A., Z. Chen, I. Sures, H. Wang, J. Schilling, and A. Ullrich. 1997. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386:181.
25. Fujioka, Y., T. Matozaki, T. Noguchi, A. Iwamatsu, T. Yamao, N. Takahashi, M. Tsuda, T. Takada, and M. Kasuga. 1996. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16:6887.
26. Stofega, M. R., H. Wang, A. Ullrich, and C. Carter-Su. 1998. Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association. J. Biol. Chem. 273:7112.
27. Minami, Y., I. Oishi, Z. J. Liu, S. Nakagawa, T. Miyazaki, and T. Taniguchi. 1994. Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor β-chain. J. Immunol. 152:5680.
28. Kim, S. O., J. Jiang, W. Yi, G. S. Feng, and S. J. Frank. 1998. Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling. J. Biol. Chem. 273:2344.
29. Perkins, L. A., I. Larsen, and N. Perrimon. 1992. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70:225.
30. Herbst, R., P. M. Carroll, J. D. Allard, J. Schilling, T. Raabe, and M. A. Simon. 1996. Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85:899.
31. Raabe, T., J. Riesgo-Escovar, X. Liu, B. S. Bausenwein, P. Deak, P. Maroy, and E. Hafen. 1996. DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell 85:911.
32. Holgado-Madruga, M., D. R. Emlet, D. K. Moscalello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379:560.
33. Carlberg, K., and L. R. Rohrschneider. 1997. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3′-kinase in myeloid cells. J. Biol. Chem. 272:15943.
34. Gu, H., J. D. Griffin, and B. G. Neel. 1997. Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells. J. Biol. Chem. 272:16421.
35. Craddock, B. L., and M. J. Welham. 1997. Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine- phosphorylated protein in hemopoietic cells. J. Biol. Chem. 272:29281
36. Frearson, J. A., and D. R. Alexander. 1998. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/Mitogen-activated protein kinase (MAPK) pathway in jurkat T cells. J. Exp. Med. 187:1417.
37. David, M., G. Zhou, R. Pine, J. E. Dixon, and A. C. Larner. 1996. The SH2 domain-containing tyrosine phosphatase PTPID is required for interferon αlβ-induced gene expression. J. Biol. Chem. 271:15862.
38. Keegan, A. D., and J. H. Pierce. 1994. The interleukin-4 receptor: signal transduction by a hematopoietin receptor. J. Leukocyte Biol. 55:272.
39. Friedmann, M. C., T. S. Migone, S. M. Russell, and W. J. Leonard. 1996. Different interleukin 2 receptor β-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. USA 93:2077.
40. Candotti, F., S. A. Oakes, J. A. Johnston, L. D. Notarangelo, J. J. O'Shea, and R. M. Blaese. 1996. In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J. Exp. Med. 183:2687.
41. Crawley, J. B., L. Rawlinson, F. V. Lali, T. H. Page, J. Saklatvala, and B. M. Foxwell. 1997. T cell proliferation in response to interleukins 2 and 7 requires p38 MAP kinase activation. J. Biol. Chem. 272:15023.
42. Gesbert, F., C. Guenzi, and J. Bertoglio. 1998. A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes. J. Biol. Chem. 273: 18273.