Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: A threshold model

Cellular Immunology

Volumn 211, Issue 2, 2001, Pages 86-95

  Wilkinson, Beverley ^a   Kaye, Jonathan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Lineage commitment; MAP kinase; Positive selection; Thymocyte

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SELECTION; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0035414814     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1006/cimm.2001.1827     Document Type: Article

References (43)

1. Selection of the T cell repertoire
2. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
3. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
4. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
5. Lck activity controls CD4/CD8 T cell lineage commitment
6. Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions
7. The quantity of TCR signal determines positive selection and lineage commitment of T cells
8. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and Lck signalling
9. Involvement of p21ras distinguishes positive and negative selection in thymocytes
10. Selective requirement for MAP kinase activation in thymocyte differentiation
11. Positive and negative selection invoke distinct signaling pathways
12. Defective thymocyte maturation in p44 MAP Kinase (Erk-1) knockout mice
13. RasGRP is essential for mouse thymocyte differentiation and TCR signaling
14. The influence of the MAPK pathway on T cell lineage commitment
15. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
16. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
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20. Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells
21. Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression
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