Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-α/β-regulated developmental transitions

Journal of Experimental Medicine

Volumn 191, Issue 4, 2000, Pages 703-715

  Lin, Kui ^a,b,c   Longo, Nancy S ^a   Wang, Xin ^a   Hewitt, Judy A ^a,d   Abraham, Kristin M ^a,b  

^a Department of Microbiology and Immunology ^*  (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cellular differentiation; Lymphocytes; Protein kinases; Signal transduction; Thymus

Indexed keywords

PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; CATALYTIC DOMAIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; THYMUS GLAND; TRANSFECTION;

EID: 0034695891     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.4.703     Document Type: Article

References (63)

1. Selective events in T cell development
2. Structure and function of the pre-T cell receptor
3. Profound block in thymocyte development in mice lacking p56lck
4. A dominant-negative transgene defines a role for p56lck in thmopoiesis
5. The protein tyrosine kinase p56lck controls allelic exclusion Of T-cell receptor β chain genes
6. T lymphocyte development in p56lck deficient mice: Allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes
7. Inhibition of T-cell receptor β-chain rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck
8. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
9. A signaling pathway governing early thymocyte maturation
10. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
11. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
12. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
13. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
14. p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function
15. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
16. Targets of p56(tlck) activity in immature thymoblasts: Stimulation of the Ras/Raf/MAPK pathway
17. The influence of the MAPK pathway on T cell lineage commitment
18. Regulation oft cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)
19. Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines
20. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
21. pp59fyn mutant mice display differential sibnaling in thymocytes and peripheral T cells
22. Delayed thymocyte development induced by augmented expression of p56(lck)
23. The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors
24. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases
25. Fyn can partially substitute for Lck in T lymphocyte development
26. The Src family of tyrosine protein kinases in hemopoietic signal transduction
27. The Lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino terminal domain
28. Interaction of the unique N-terminal region of the tyrosine kinase p56lck with the cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
29. p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain
30. SH2 domains of the protein-tyrosine kinases Blk, Lyn, and Fyn(T) bind distinct sets of phosphoproteins from B lymphocytes
31. Identification of Src, Fyn, and Lyn SH3-binding proteins: Implications for a function of SH3 domains
32. The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor
33. Disease specificity of kinase domains: The src-encoded catalytic domain converts erbB into a sarcoma oncogene
34. A kinase-independent function of Lck in potentiating antigen-specific T cell activation
35. A lymphocyte-specific protein-tyrosine kinase is rear-ranged and overexpressed in the murine T cell lymphoma LSTRA
36. Neoplastic transformation induced by an activated lymphocyte-specific protein kinase (p56lck)
37. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells
38. Expression and function of CD4 in a murine T-cell hybridoma
39. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells
40. Acquisition of transforming properties by FYN, a normal SRC-related human gene
41. Dissection of thymocyte signaling pathways by in vivo expression of pertussis-toxin ADP ribosyltransferase
42. Detection of transgene integrants and homologous recombinants in mice by polymerase chain reaction
43. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
44. Oncogenes and signal transduction
45. Oncogenic activation of p59fynT tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528
46. Two lck transcripts containing different 5' untranslated regions are present in T cells
47. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line
48. Developmental regulation of lck gene expression in T lymphocytes
49. Decreased signaling competence as a result of receptor overexpression: Overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes
50. + thymocytes in vitro induces early aspects of positive selection, but not apoptosis
51. + TCR(hi) thymocytes
52. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
53. Involvement of p21ras activation in T cell CD69 expression
54. Restoration of thymopoiesis in pTα(-/-) mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα
55. Thymic tumorigenesis induced by over-expression of p56(lck)
56. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2
57. Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk
58. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain
59. Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the fyn tyrosine protein kinase, in T cells
60. Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
61. The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling
62. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
63. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages