The mle(napts) RNA helicase mutation in Drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing

Neuron

Volumn 25, Issue 1, 2000, Pages 139-149

  Reenan, Robert A ^a   Hanrahan, Christopher J ^a   Ganetzky, Barry ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; DOUBLE STRANDED RNA; INOSINE; RNA HELICASE; SODIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; GENE EXPRESSION REGULATION; GENE MUTATION; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA EDITING; RNA SPLICING; RNA STRUCTURE;

DROSOPHILA;

EID: 0034101060     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80878-8     Document Type: Article

References (43)

1. Auffray, C., and Rougeon, F. (1980). Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem. 107, 303-314.
2. Bass, B.L. (1997). RNA editing and hypermutation by adenosine. Trends Biochem. Sci. 22, 157-162.
3. Bass, B.L., Nishikura, K., Keller, W., Seeburg, P.H., Emeson, R.B., O'Connell, M.A., Samuel, C.E., and Herbert, A. (1997). Astandardized nomenclature for adenosine deaminases that act on RNA. RNA 3, 947-949.
4. Burns, C.M., Chu, H., Rueter, S.M., Hutchinson, L.K., Canton, H., Sanders-Bush, E., and Emeson, R.B. (1997). Regulation of serotonin-2c receptor G-protein coupling by RNA editing. Nature 387, 303-308.
5. Chabot, B., Blanchette, M., Lapierre, I., and La Branche, H. (1997). An intron element modulating 5′ splice site selection in the hnRNP A1 pre-mRNa interacts with hnRnp A1 Mol. Cell. Biol. 17,1776-1786.
6. Eng, F.J., and Warner, J.R. (1991). Structural basis for the regulation of splicing of a yeast messenger RNA. Cell 65, 797-804.
7. Ganetzky, B. (1984). Genetic studies of membrane excitability in Drosophila: Lethal interaction between two temperature-sensitive paralytic mutations. Genetics 108, 897-911.
8. Ganetzky, B.,and Wu, C.F. (1982a). Drosophila mutants with opposing effects on nerve excitability: Genetic and spatial interactions in repetitive firing. J. Neurophysiol. 47, 501-514.
9. Ganetzky, B., and Wu, C.F. (1982b). Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila. Genetics 100, 597-614.
10. Gibson, T.J., and Thompson, J.D. (1994). Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: Implications for monomeric RNA helicases. Nucleic Acids Res. 22, 2552-2556.
11. Goguel, V., Wang, Y., and Rosbash, M. (1993). Short artificial hairpins sequester splicing signals and inhibit yeast pre-mRNA splicing. Mol. Cell. Biol. 13, 6841-6848.
12. Herb, A., Higuchi, M., Sprengel, R., and Seeburg, P.H. (1996). Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc. Natl. Acad. Sci. USA 93, 1875-1880.
13. Higuchi, M., Single, F.N., Kohler, M., Sommer, B., Sprengel, R., and Seeburg, P.H. (1993). RNA editing of AMPA receptor subunit GluR-b: A base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370.
14. Hong, C.S., and Ganetzky, B. (1994). Spatial and temporal expression patterns of two sodium channel genes in Drosophila. J. Neurosci. 14, 5160-5169.
15. Kelley, R.L., and Kuroda, M.I. (1995). Equality for X chromosomes. Science 270, 1607-1610.
16. Kemp, B.E., and Pearson, R.B. (1990). Protein kinase recognition sequence motifs. Trends Biochem. Sci. 15, 342-346.
17. Kennelly, P.J., and Krebs, E.G. (1991). Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266, 15555-15558.
18. Kernan, M.J., Kuroda, M.I., Kreber, R., Baker, B.S., and Ganetzky, B. (1991). Napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription. Cell 66, 949-959.
19. Kharrat, A., Macias, M.J., Gibson, T.J., Nilges, M., and Pastore, A. (1995). Structure of the dsRNA binding domain of E. Coli RNase III. EMBO J. 14, 3572-3584.
20. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing. Neuron 10, 491-500.
21. Krawczak, M., Reiss, J., and Cooper, D.N. (1992). The mutational spectrum of single base-pair substitutions in mRna splice junctions of human genes: Causes and consequences. Hum. Genet. 90,41-54.
22. Kuroda, M.I., Kernan, M.J., Kreber, R., Ganetzky, B., and Baker, B.S. (1991). The maleless protein associates with the X chromosome to regulate dosage compensation in Drosophila. Cell 66, 935-947.
23. Lee, C.G., and Hurwitz, J. (1992). A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3′ to 5′ direction. J. Biol. Chem. 267, 4398-4407.
24. Lee, C.G., and Hurwitz, J. (1993). Human RNA helicase A is homologous to the maleless protein of Drosophila. J. Biol. Chem. 268, 16822-16830.
25. Lee, C.G., Chang, K.A., Kuroda, M.I., and Hurwitz, J. (1997). The NTPase/helicase activities of Drosophila maleless, an essential factor in dosage compensation. EMBO J. 16, 2671-2681.
26. Lee, C.G., da Costa Soares, V., Newberger, C., Manova, K., Lacy, E., and Hurwitz, J. (1998). RNA helicase A is essential for normal gastrulation. Proc. Natl. Acad. Sci. USA 95, 13709-13713.
27. Lin, J., and Rossi, J.J. (1996). Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3′ splice site. RNA 2, 835-848.
28. Liu, H.X., Goodall, G.J., Kole, R., and Filipowicz, W. (1995). Effects of secondary structure on pre-mrna splicing : Hairpins sequestering the 5′ but not the 3′ splice site inhibit intron processing in Nicotiana plumbaginifolia. EMBO J. 14, 377-388.
29. Lomeli, H., Mosbacher, J., Melcher, T., Hoger, T., Geiger, J.R., Kuner, T., Monyer, H., Higuchi, M., Bach, A., and Seeburg, P.H. (1994). Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 266, 1709-1713.
30. Loughney, K., Kreber, R., and Ganetzky, B. (1989). Molecular analysis of the para locus, a sodium channel gene in Drosophila. Cell 58, 1143-1154.
31. Machesky, L.M., Insall, R.H., and Kay, R.R. (1998). The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum. Curr. Biol. 8, 607-610.
32. Niswender, C.M., Copeland, S.C., Herrick-Davis, K., Emeson, R.B., and Sanders-Bush, E. (1999). RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J. Biol. Chem. 274, 9472-9478.
33. Park, S., and Lim, J.K. (1995). A microinjection technique for ethanoltreated eggs and a mating scheme for detection of germline transformants. Dros. Inf. Serv. 76, 197-199.
34. Polson, A.G., and Bass, B.L. (1994). Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase. EMBO J. 13, 5701-5711.
35. Powell, J.R. (1997). Progress and Prospects in Evolutionary Biology: The Drosophila Model (New York: Oxford University Press).
36. Rueter, S.M., and Emeson, R.B. (1998). Adenosine-to-lnosine conversion in mRNA. In Modification and Editing of RNA, H. Grosjean and R. Benne, eds. (Washington, D.C.: ASM Press), pp. 343-361.
37. Solnick, D. (1985). Alternative splicing caused by RNA secondary structure. Cell 43, 667-676.
38. Solnick, D., and Lee, S.I. (1987). Amount of RNA secondary structure required to induce an alternative splice. Mol. Cell. Biol. 7, 3194-3198.
39. Stern, M., Kreber, R., and Ganetzky, B. (1990). Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability. Genetics 124, 133-143.
40. Thackeray, J.R., and Ganetzky, B.(1994). Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms. J. Neurosci. 14, 2569-2578.
41. Wu, C.F., Ganetzky, B., Jan, L.Y., and Jan, Y.N. (1978). A drosophila mutant with a temperature-sensitive block in nerve conduction. Proc. Natl. Acad. Sci. USA 75, 4047-4051.
42. Zaffran, S., Chartier, A., Gallant, P., Astier, M., Arquier, N., Doherty, D., Gratecos, D., and Semeriva, M. (1998). A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Development 125, 3571-3584.
43. Zhang, S., Maacke, H., and Grosse, F. (1995). Molecular cloning of the gene encoding nuclear DNA helicase II. A bovine homologue of human RNA helicase A and Drosophila MLE protein. J. Biol. Chem. 270, 16422-16427.