Human RNA-specific adenosine deaminase (ADAR1) gene specifies transcripts that initiate from a constitutively active alternative promoter

Gene

Volumn 258, Issue 1-2, 2000, Pages 165-172

  Kawakubo, Ken ^a   Samuel, Charles E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenosine deamination; ADR; Double stranded RNA; Interferon action; RNA editing; Transcriptional regulation

Indexed keywords

ADENOSINE DEAMINASE; COMPLEMENTARY DNA; INTERFERON; MESSENGER RNA;

AMNION; ARTICLE; CONTROLLED STUDY; DEAMINATION; DNA SEQUENCE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PLACENTA; PRIORITY JOURNAL; PROMOTER REGION; RNA EDITING; TRANSCRIPTION REGULATION;

5' UNTRANSLATED REGIONS; ADENOSINE DEAMINASE; ALTERNATIVE SPLICING; CELLS, CULTURED; DNA, COMPLEMENTARY; EXONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LUCIFERASES; MALE; NUCLEASE PROTECTION ASSAYS; PHYSICAL CHROMOSOME MAPPING; PREGNANCY; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 0034722628     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00368-1     Document Type: Article

References (26)

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3. Regulation of serotonin-2C receptor G-protein coupling by RNA editing
4. Biased (A→I) hypermutation of animal RNA virus genomes
5. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
6. Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible
7. Characterization of the 5'-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter
8. Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing
9. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
10. Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of the human and mouse Pkr genes
11. Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts
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14. Serotonin-2C receptor pre-mRNA editing in rat brain and in vitro by splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase ADAR1
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16. Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase
17. Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase
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21. A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs
22. Genomic organization and chromosomal location of the human dsRNA adenosine deaminase gene: the enzyme for glutamate-activated ion channel RNA editing
23. Cloning and chromosomal location of human genes inducible by type I interferon
24. The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to chromosome 1q21.1-21.2