Brain control of penile erection

World Journal of Urology

Volumn 19, Issue 1, 2001, Pages 1-8

  Rampin, O ^a   Giuliano, F ^b  

^a CEMAGREF   (France)

^b BICÊTRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DRUG EFFECT; HUMAN; MALE; PENIS ERECTION; PHYSIOLOGY; REVIEW; SPINAL CORD;

BRAIN; HUMANS; MALE; PENILE ERECTION; SPINAL CORD;

EID: 0035260549     PISSN: 07244983     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00007089     Document Type: Article

References (89)

1. Ackerman AE, Lange GM, Clemens LG (1997) Effects of paraventricular lesions on sex behavior and seminal emission in male rats. Physiol Behav 63: 49-53
2. Andersson KE, Gemalmaz H, Waldeck K, Chapman TN, et al (1999) The effect of sildenafil on apomorphine-evoked increases in intracavernous pressure in the awake rat. J Urol 161: 1707 1712
3. Araki L, DeGroat WC (1996) Unitary excitatory synaptic currents in preganglionic neurons mediated by two distinct groups of interneurons in neonatal rat sacral parasympathelic nucleus. J Neurophysiol: 76: 215 226
4. Argiolas A. Melis MR, Murgia S. Schioth HB (2000) ACTHancl alpha-MSH induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors. Brain Res Bull 51: 425431
5. Arletti R, Calza L, Giardino L, Benelli A, et al (1997) Sexual impotence is associated with a reduced production of oxytocin and with an increased production of opioid peptides in the paraventricular nucleus of male rats. Neurosci Lett 233: 65-68
6. Aston-Jones G, Shipley MT, Grzanna R (1995) The locus coeruleus, A5 and A 7 noradrenergic cell groups. In: Paxinos G. (ed) The rat nervous system. Academic, San Diego, pp 183-213
7. Bancroft J (1995) Are the effects of androgens on male sexuality noradrenergically mediated? Some consideration of the human. Neurosci Biobehav Rev 19: 325-330
8. Bernabé J, Rampin O, McKenna KE, Giuliano F (1997) Spinal regulation of erection by oxytocin: a pharmacological approach in the rat. Soc Neurosci Abstr 23: 1520
9. Bitran D, Thompson JT, Hull EM, Sachs BD (1989) Quinerolane (LY163502), a D2 dopamine receptor agonist, facilitates seminal emission, but inhibits penile erection in the rat. Pharmacol Biochem Behav 34: 453458
10. Björklund A, Skagerberg G (1979) Evidence for a major spinal projection from the diencephalic All dopamine cell group in the rat using transmitter-specific fluorescent retrograde tracing. Brain Res 177: 170-175
11. Buijs RM, Swaab DF, Dogterom DF, Van Leeuwen FW (1978) Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Cell Tissue Res 186: 423-433
12. Burnett AL, Saito S, Maguire M, Yamaguchi H, Chang TSK, Hanley DF (1995) Localization of nitric oxide synthase in spinal nuclei innervating pelvic ganglia. J Urol 153: 212-217
13. Chen KK, Chan JY, Chang LS (1999) Dopaminergic neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat. J Urol 162: 237 242
14. Danuser H, Thor KB (1995) Inhibition of central sympathetic and somatic outflow to the lower urinary tract of the cat by the alphal adrenergic receptor antagonist prazosin. J Urol 153: 1308-1312
15. Downie JW, Bialik GJ (1988) Evidence for a spinal site of action of clonidine on somatic and viscerosomatic reflex activity evoked on the pudendal nerve in cats. J Pharmacol Exp Ther 246: 352 358
16. Du J, Lorrain DS, Hull EM (1998) Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats. Brain Res 782: 11-17
17. Du J, Hull EM (1999) Effects of testosterone on neuronal nitricoxide synthase and tyrosine hydroxylase. Brain Res 836: 90-98
18. Dun NJ, Dun SL, Wu SY, Forstermann U, Schmidt HHHW, Tseng LF (1993) Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience 54: 845-857
19. Ernst E, Pittler MH (1998) Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. JUrol 159:43336
20. Fritschy JM, Lyons WE, Müllen CA, Kosovsky BE, Molliver ME, Grzanna R (1987) Distribution of locus coeruleus axons in the rat spinal cord: a combined anterograde transport and immunohistochemical study. Brain Res 437: 176-180
21. Giuliano F, Rampin O, Jardin A, Rousseau JP (1987) Electrophysiological study of relations between the dorsal nerve of the penis and the lumbar sympathetic chain in the rat. J Urol 150: 1960-1964
22. Giuliano F, Rampin O (2000) Central neural regulation of penile erection. Neurosci Biobehav Rev 24: 517-533
23. Gomez-Marrero J, Feria M. Mas M (1988) Stimulation of opioid receptors suppresses penile erectile reflexes and seminal emission in rats. Pharmacol Biochem Behav 31: 393-396
24. Heaton JP (2000) Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine. Neurosci Biobehav Rev 24: 561-569
25. Hernandez-Gonzalez M, Oropeza MV, Guevara MA (1994) Cervantes M, Morali G. Effects of intrathecal administration of adrenergic agonists on the frequency of copulatory pelvic thrusting of the male rat. Arch Med Res 25: 419125
26. Hökfelt T, Phillipson O, Goldstein M (1979) Evidence for a dopaminergic pathway in the rat descending from the All cell group to the spinal cord. Acta Physiol Scand 107: 393-395
27. Holmes GM, Rogers RC, Bresnahan JC, Beattie MS (1997) Differential effects of intrathecal thyrotropin-releasing hormone (TRH) on perineal reflexes in male rats. Physiol Behav 61: 57-63
28. Holstege G, Blök BFM, ter Horst GJ (1995) Brainstem systems involved in the blink reflex, feeding mechanisms, and micturition. In: Paxinos G (ed) The rat nervous system, 2nd edn. Academic. San Diego, pp 257-275
29. Hubscher CH, Johnson RD (1996) Responses of medullary reticular formation neurons to input from the male genitalia. J Neurophysiol 76: 2474-2482
30. Hubscher CH. Johnson RD ( 1999) Effects of acute and chronic midthoracic spinal cord injury on neural circuits for male sexual function. I. Ascending pathways. J Neurophysiol 82: 1381 1389
31. Johnson RD, Hubscher CH (2000) Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch. Neuroreport 11: 379 382
32. Langley JN, Anderson H K (1895) The innervation of the pelvic and adjoining viscera. J Physiol 19: 71-130
33. Lee RL. Smith ER, Mas M, Davidson JM (1990) Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats. Physiol Behav 47: 665-669
34. Leipheimer RE, Sachs BD (1988) GABAergic regulation of penile reflexes and copulation in rats. Physiol Behav 42: 351 357
35. Liu YC, Salamone JD, Sachs BD (1997) Lesions in medial preoptic area and bed nucleus of stria terminalis: differential effects on copulatory behavior and noncontact erection in male rats. J Neurosci 17: 5245-5253
36. Liu YC, Sachs BD (1999) Erectile function in male rats after lesions in the lateral paragigantocellular nucleus. Neurosci Lett 262: 203-206
37. Manzo J, Cruz MR, Hernandez ME, Pacheco P, Sachs BD (1999) Regulation of noncontact erection in rats by gonadal steroids. Horm Behav 35: 264 270
38. Marlier L. Teilhac JR. Cerruti C, Privat A (1991) Autoradiographie mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain Res 550: 15-23
39. Marson L. McKenna K E (1992) A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res 88: 313-320
40. Marson L. McKenna KE (1994) Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharmacol Biochem Behav 47: 883-888
41. Marson L, McKenna KE (1994) Stimulation of the hypothalamus initiates the urethrogenital reflex in male rats. Brain Res 638: 103 108
42. Marson L, McKenna KE (1996) CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: a transneuronal tracing study using pseudorabies virus. J Comp Neurol 374: 161-179
43. Marson L, List MS, McKenna KE (1992) Lesions of the nucleus paragigantocellularis alter ex copula penile reflexes. Brain Res 592: 187-192
44. Marson L, Platt KB, McKenna KE (1993) Central nervous system innervation of the penis as revealed by the trans- neuronal transport of pseudorabies virus. Neuroscience 55: 263-280
45. Mas M, Zahradnik MA, Martino V, Davidson JM (1985) Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes. Brain Res 342: 128-134
46. Mathes CW. Smith ER, Popa BR, Davidson JM (1990) Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats. Pharmacol Biochem Behav 36: 63-68
47. McKenna K E (2000) Some proposals regarding the organization of the central nervous system control of penile erection. Neurosci Biobehav Rev 24: 535-540
48. Meisel RL, Sachs BD (1994)The physiology of male sexual behavior. In: Knobil E, Neill J (eds) The physiology of reproduction, 2nd edn. Raven. New York, pp 3-105
49. Melis RM, Succu S, Mauri A, Argiolas A (1998) Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during noncontact penile erections and copulation. Eur J Neurosci 10: 1968-1974
50. Melis RM, Spano MS, Succu S, Argiolas A (1999) The oxytocin antagonist, d(CH2)5 Tyr(Me)2-Orn8-vasotocin reduces noncontact penile erections in male rats. Neurosci Lett 265: 171-174
51. Melis RM, Succu S, Spano MS, Argiolas A (1999) Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: involvement of nitric oxide. Eur J Neurosci 11: 1857-1864
52. Melis R, Spano MS, Succu S, Argiolas A (2000) Activation of gamma-aminobutyric acid (A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methylD-aspartic acid- and oxytocin-induced penile erection and yawning in male rats. Neurosci Lett 281: 127-130
53. Melis RM, Spano MS, Succu S, Argiolas A (2000) Activation of gamma-aminobutyric acid (A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methyl-D-aspartic acid- and oxytocin-induced penile erection and yawning in male rats. Neurosci Lett 281: 127-130
54. Millan MJ, Millan MH, Czlonkowski A, Herz A (1984) Vasopressin and oxytocin in the rat spinal cord: distribution and origins in comparison to [Met]enkephalin, dynorphin and related opioids and their irresponsiveness to stimuli modulating neurohypohyseal secretion. Neuroscience 13: 179-187
55. Peng Y, Kohno J, Shinoda K, Kawai Y, Ono K. Jiang W, Shiotani Y (1989) Interaction between cholinergic neurons and substance P or calcitonin gene-related peptide terminals of the rat sacral intermediolateral nucleus: double immunostaining at the light and electron microscopic levels. J Comp Neurol 285: 1-8
56. Phelan KD. Newton BW (2000) Sex differences in the response of postnatal rat lumbar lamina X neurons to exogenously applied galanin recorded in vitro. Dev Brain Res 122: 157-163
57. Rampin O, Bernabé J. Rousseau JP (1996) Effects of the NMDA glutamatergic receptor antagonist MK-801 on reflexive erections in the rat. Soc Neurosci Abstr 22: 1053
58. Rampin O, Gougis S, Giuliano F, Rousseau JP (1997) Spinal Eos labeling and penile erection elicited by stimulation of the dorsal nerve of the penis in the rat. Am J Physiol 272: R1425R1431
59. Reiter MK. Kremarik P, Freund-Mercier MJ, Stoeckel ME, Desaulles E. Feltz P (1994) Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur J Neurosci 6: 98 104
60. Ridet JL, Sandillon F, Rajaofetra N, Geffard M, Privat A (1992) Spinal dopaminergic system of the rat: light and electron microscopic study using an antiserum against dopamine, with particular emphasis on synaptic incidence. Brain Res 598: 233-241
61. Ridet JL, Tamir H, Privat A (1994) Direct immunocytochemical localization of 5-hydroxytryptamine receptors in the adult rat spinal cord: a light and electron microscopic study using an anti-idiotypic antiserum. J Neurosci Res 38: 109-121
62. Rousselot P, Papadopoulos G, Merighi A, Poulain DA, Theodosis DT (1990) Oxytocinergic innervation of the rat spinal cord. Brain Res 529: 178-184
63. Saito S, Kidd GJ, Trapp BD. Dawson TM, Bredl DS, Wilson DA, Traystman RJ, Snyder SH, Hanley DF (1994) Rat spinal cord neurons contain nitric oxide synthase. Neuroscience 59: 447 56
64. Sasek CA, Seybold VS, Eide RP (1984) The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord. Neuroscience 12: 855-873
65. Sato Y, Christ GJ, Horita H, Adachi H, et al (1999) The effects of alterations in nitric oxide levels in the paraventricular nucleus on copulatory behavior and reflexive erections in male rats. J Urol 162: 2182-2185
66. Sato Y, Christ GJ (2000) Differential ICP responses elicited by electrical stimulation of medial preoptic area. Am J Physiol 278: H964-H970
67. Schoenen J, Lotstra F, Vierendeels G, Reznik M. Vanderhaeghen JJ (1985) Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord. Neurology 35: 881-890
68. Schröder HD (1984) Somatostatin in the caudal spinal cord: an immunohistochemical study of the spinal centers involved in the innervation of pelvic organs. J Comp Neurol 233: 400-414
69. Skajerberg G, Björklund A, Lindvall O, Schmidt RH (1982) Origin and termination of the diencephalo-spinal dopamine system in the rat. Brain Res Bull 9: 237-244
70. Skajerberg R, Lindvall O (1985) Organization of diencephalic dopamine neurons projecting to the spinal cord of the rat. Brain Res 342: 340-351
71. Smith ER, Lee RL, Schnur SL, Davidson JM (1987) Alpha2adrenoceptor antagonists and male sexual behavior: II. Erectile and ejaculatory reflexes. Physiol Behav 41: 15-19
72. Smith ER, Cetrulo EJ, Donahue JP, Sparrow H, Davidson JM, Hoffman BB, Clark JT (1995) The inhibitory effects of propranolol on genital reflexes in male rats. Pharmacol Biochem Behav 52: 541-546
73. Steers WD (2000) Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications. Neurosci Biobehav Rev 24: 507-516
74. Steers WD, DeGroat WC (1989) Effects of m-chlorophenylpiperazine on penile and bladder function in rats. Am J Physiol 257: R1441-R1449
75. Steers WD, Mallory B, DeGroat WC (1988) Electrophysiological study of neural activity in penile nerve of the rat. Am J Physiol 254: R989-R1000
76. Svenson L, Hansen S (1984) Spinal monoaminergic modulation of masculine copulatory behavior in the rat. Brain Res 302: 315 321
77. Swanson LW, McKellar S (1979) The distribution of oxytocinand neurophysin-stained fibers in the spinal cord of the rat and monkey. J Comp Neurol 188:87-106
78. Tai C. Booth AM, De Groat WC. Roppolo JR (1998) Penile erection produced by microstimulation of the sacral spinal cord of the cat. IEEE Trans Rehabil Eng 6 : 374 381
79. Tang Y, Rampin O, Facchinetti P, Calas A, Giuliano F (1998) Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat. Neuroscience 82: 241-254
80. Tang Y. Rampin O, Giuliano F, Ugolini G (1999) Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: retrograde transneuronal tracing with rabies virus. J Comp Neurol 167-192
81. Thor KB, Nickolaus S, Heike CJ (1993) Autoradiographic localization of 5-hydroxytryptamineiA, 5-hydroxytryptamineiβ and 5-hydroxytryptamineic;2 binding sites in the rat spinal cord. Neuroscience 55: 235-252
82. Valtschanoff JG, Weinberg RJ, Rustioni A (1992) NADPH diaphorase in the spinal cord of rats. J Comp Neurol 321: 209-222
83. Véronneau-Longueville F, Rampin O, Freund-Mercier MJ, Tang Y, Calas A, Marson L, McKenna KE, Stoeckel ME, Benoit G, Giuliano F (1999) Oxytocinergic innervation of autonomie nuclei controlling penile erection in the rat. Neuroscience 93: 1437-1447
84. Vizzard MA, Erdman SL, DeGroat WC (1993) Localization of NADPH-diaphorase in pelvic afferent and efferent pathways of the rat. Neurosci Lett 152: 72-76
85. Vizzard MA, Erdman SL, Förstermann U, DeGroat WC (1994) Ontogeny of nitric oxide synthase in the lumbosacral spinal cord of the neonatal rat. Dev Brain Res 81: 201-217
86. Westlund KN, Bowker RM, Ziegler MG, Coulter JD (1983) Noradrenergic projections to the spinal cord of the rat. Brain Res 236: 15-31
87. Westlund KN, Bowker RM, Ziegler MG, Coulter JD (1984) Origins and terminations of descending noradrenergic projections to the spinal cord of monkey. Brain Res 292: 1-16
88. Woodford BJ, Carter RR, McCreery D, Bullara LA, Agnew WF (1996) Histopathologic and physiologic effects of chronic implantation of microelectrodes in sacral spinal cord of the cat. J Neuropathol Exp Neurol 55: 982-991
89. Wu W, Eide R, Wessendorf MW (1993) Organization of the serotoninergic innervation of spinal neurons in rats-IIl. Differential serotoninergic innervation of somatic and parasympathetic preganglionic motoneurons as determined by patterns of co-existing peptides. Neuroscience 55: 223-233