Some proposals regarding the organization of the central nervous system control of penile erection

Neuroscience and Biobehavioral Reviews

Volumn 24, Issue 5, 2000, Pages 535-540

  McKenna, K E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Erectile dysfunction; Impotence; Penis; Sexual responses

Indexed keywords

SEX HORMONE;

CENTRAL NERVOUS SYSTEM; ERECTILE DYSFUNCTION; HUMAN; IMPOTENCE; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; REVIEW; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SPINAL CORD; SPINAL REFLEX;

ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; MALE; PENILE ERECTION; SPINAL CORD;

EID: 0034086854     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(00)00021-X     Document Type: Review

References (57)

1. Ackerman A.E., Clemens L.G. Oxytocin projections from the paraventricular nucleus of the hypothalamus to lower lumbar spinal cord and distribution of oxytocin fibers in the region of the spinal nucleus of the bulbocavernosus in male and female rats. Soc. Neurosci. Abstr. 152:1992;14.
2. Argiolas A., Melis M.R., Gessa G.L. Oxytocin: an extremely potent inducer of penile erection and yawning in male rats. Eur. J. Pharmacol. 130:1986;265-272.
3. Arnold A.P., Gorski R.A. Gonadal steroid induction of structural sex differences in the central nervous system. Ann. Rev. Neurosci. 7:1984;413-442.
4. Azami J., Wright D.H., Roberts M.H.T. Effects of morphine and naloxone on the responses to noxious stimulation of neurons in the nucleus reticularis paragigantocellularis. Neuropharmacology. 20:1981;869-876.
5. Bandler R., Shipley M.T. Columnar organization in the midbrain periaqueductal gray: Modules for emotional expression? TINS. 17:1994;379-389.
6. Beach F.A. Cerebral and hormonal control of reflexive mechanisms involved in copulatory behavior. Physiol. Rev. 47:1967;289-316.
7. Behbehani M.M. Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 46:1995;574-605.
8. Bernabé J, Rampin O, McKenna KE, Giuliano, F. Spinal regulation of erection by oxytocin: A pharmacological approach in the rat. Soc. Neurosci. Abstr. 1997; 23; 1520.
9. Bors E., Comarr A.E. Neurological disturbances of sexual function with special reference to 529 patients with spinal cord injury. Urol. Survey. 10:1960;191-222.
10. Breedlove S.M. Steroid influences on the development and function of a neuromuscular system. Prog. Brain Res. 61:1984;147-170.
11. Breedlove S.M., Arnold A.P. Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science. 210:1980;564-566.
12. Brindley G.S. Sexual and reproductive problems of paraplegic men. Clarke J.R. Oxford Reviews of Reproductive Biology. 1986;214-222 Clarendon Press, Oxford.
13. Cechetto D.F., Saper C.B. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J. Comp. Neurol. 272:1988;579-604.
14. Collins W.F. Electrophysiology of motoneurons in the spinal nucleus of the bulbocavernosus in the rat. Soc. Neurosci. Abstr. 11:1985;883.
15. Collins J.T., III R.D. Pudendal motor and premotor neurons in the male rat: A WGA transneuronal study. J. Comp. Neurol. 308:1991;28-41.
16. Comarr A.E. Sexual Function Among Patients with Spinal Cord Injury. Urol. Int. 25:1970;134-168.
17. Coolen L.M., Peters H.J.P.W., Veening J.G. Fos immunoreactivity in the rat brain following consummatory elements of seual behavior: a sex comparison. Brain Res. 738:1996;67-82.
18. Fedirchuk B., Song L., Downie J.W., Shefchyk S.J. Spinal distribution of extracellular field potentials generated by electrical stimulation of pudendal and perineal afferents in the cat. Exp. Brain Res. 89:1992;517-520.
19. Feldman J.L. Neurophysiology of breathing in mammals. Bloom F.E. Handbook of Physiology: The Nervous System IV. 1986;463-524 American Physiological Society, Bethesda.
20. Fukuda H., Fukai K. Ascending and descending pathways of reflex straining in the dog. Jap. J. Physiol. 36:1986;905-920.
21. Fukuda H., Fukai K. Discharges of bulbar respiratory neurons during rhythmic straining evoked by activation of pelvic afferent fibers in dogs. Brain Res. 449:1988;157-166.
22. Fukuda H., Fukai K., Yamane M., Okada H. Pontine reticular unit responses to pelvic nerve and colonic mechanical stimulation in the dog. Brain Res. 207:1981;59-71.
23. Greco B., Edwards D.A., Michael R.P., Zumpe D., Clancy A.N. Colocalization of androgen receptors and mating-induced FOS immunoreactivity in neurons that project to the central tegmental field in male rats. J. Comp. Neurol. 408:1999;220-236.
24. Greco B., Edwards D.A., Zumpe D., Michael R.P., Clancy A.N. Fos induced by mating or noncontact sociosexual interaction is colocalized with androgen receptors in neurons within the forebrain, midbrain, and lumbosacral spinal cord of male rats. Horm. Behav. 33:1998;125-138.
25. Greco B., Edwards D.A., Zumpe D., Clancy A.N. Androgen receptor and mating-induced fos immunoreactivity are co-localized in limbic and midbrain neurons that project to the male rat medial preoptic area. Brain Res. 781:1998;15-24.
26. Hart B.L. Testosterone regulation of sexual reflexes in spinal male rats. Science. 155:1967;1283-1284.
27. Hart B.L. Reflexive mechanisms of copulatory behavior. McGill T.E., Dewsbury D.A., Sachs B.D. Sex and Behavior. 1978;Plenum Press, New York.
28. Honda C.N. Visceral and somatic afferent convergence onto neurons near the central canal in the sacral spinal cord of the cat. J. Neurophysiol. 11:1985;1059-1076.
29. Hubscher C.H., Johnson R.D. Responses of medullary reticular formation neurons to input from the male genitalia. J. Neurophysiol. 76:1996;2474-2482.
30. Loewy A.D., Wallach J.H., McKellar S. Efferent connections of the ventral medulla oblongata in the rat. Brain Res. Rev. 3:1981;63-80.
31. Marson L, Neuronal pathways involved in the defense reaction. PhD Thesis, University of Birmingham, UK, 1984.
32. Marson L., McKenna K.E. CNS cell groups involved in the control of the ischiocavernosus and bulbospongiosus muscles: A transneuronal tracing study using pseudorabies virus. J. Comp. Neurol. 374:1996;161-179.
33. Marson L., McKenna K.E. The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Res. 515:1990;303-308.
34. Marson L., McKenna K.E. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp. Brain Res. 88:1992;313-320.
35. Marson L., Platt K.B., McKenna K.E. CNS innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience. 55:1993;263-280.
36. Marson L., List M.S., McKenna K.E. Lesions of the nucleus paragigantocellularis alter ex copula penile reflexes. Brain Res. 592:1992;187-192.
37. Mason P., Leung C.G. Physiological functions of pontomedullary raphe and medial reticular neurons. Holstege G., Bandler R., Saper C.B. Progress in Brain Research. 1996;Elsevier, Amsterdam.
38. McKenna K.E., Nadelhaft I. The pudendo-pudendal reflex in male and female rats. J. Auton. Nerv. Sys. 27:1989;67-77.
39. McKenna K.E., Chung S.K., McVary K.T. A model for the study of sexual function in anesthetized male and female rats. Am. J. Physiol. 261:1991;R1276-1285.
40. Meisel R.L., Sachs B.D. The physiology of male sexual behavior. Knobil E., Neill J.D. The Physiology of Reproduction. Vol. 2:1994;3-105 Raven Press, New York.
41. Murphy A.Z., Rizvi T.A., Ennis M., Shipley M.T. The organization of preoptic-medullary circuits in the male rat: evidence for interconnectivity of neural structures involved in reproductive behavior, antinociception and cardiovascular regulation. Neuroscience. 91:1999;1103-1116.
42. Peshori K.R., Erichsen J.T., Collins W.F. III. Differences in the connectivity of rat pudendal motor nuclei as revealed by retrograde transneuronal transport of wheat germ agglutinin. J. Comp. Neurol. 353:1995;119-128.
43. Rampin O., Gougis S., Giuliano F., Rousseau J.P. Spinal Fos labeling and penile erection elicited by stimulation of dorsal nerve of the rat penis. Am. J. Physiol. 272:1997;R1425-R1431.
44. Rose J.D. Brainstem Influences on Sexual Behavior. Klemm W.R., Vertes R.P. Brainstem Mechanisms of Behavior. 1990;407-463 John Wiley, New York.
45. Rose J.D. Forebrain influences on brainstem and spinal mechanisms of copulatory behavior: A current perspective on Frank Beach's contribution. Neurosci. Biobehav. Rev. 14:1990;207-215.
46. Sachs B.D. Placing erection in context: the reflexogenic-psychogenic dichotomy reconsidered. Neurosci. Biobehav. Rev. 19:1994;211-224.
47. Saper C.B., Loewy A.D., Swanson L.W., Cowan W.M. Direct hypothalamo-autonomic connections. Brain Res. 117:1976;305-312.
48. Sar M., Stumpf W.E. Distribution of androgen concentrating neurons in the rat brain. Stumpf W.E., Grant L.D. Anatomical Neuroendocrinology. 1975;120-133 Karger, Basel.
49. Simerly R.B., Swanson L.W. The organization of neural inputs to the medial preoptic nucleus of the rat. J. Comp. Neurol. 246:1986;312-342.
50. Simerly R.B., Swanson L.W. Projections of the medial preoptic nucleus: Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat. J. Comp. Neurol. 270:1988;209-242.
51. Swanson L.W. The hypothalamus. Hökfelt T., Björklund A., Swanson L.W. Handbook of Chemical Neuroanatomy, Integrated Systems. Vol. 5:1987;1-124 Elsevier, Amsterdam.
52. Valiquette G., Haldar J., Abrams G.M., Nilaver G., Zimmerman E.A. Extrahypothalamic neurohypophyseal peptides in the rat central nervous system. Brain Res. 331:1985;176-179.
53. Veening J.G., Coolen L.M. Neural activation following sexual behavior in the male and female rat brain. Behav. Brain Res. 92:1998;181-193.
54. Véronneau-Longueville F., Rampin O., Freund-Mercier M.-J., Tang Y., Calas A., Marson L., McKenna K.E., Stoeckel M.E., Benoit G., Giuliano F. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience. 93:1999;1437-1447.
55. Wagner C.K., Clemens L.G. Projections of the paraventricular nucleus of the hypothalamus to the sexually dimorphic lumbosacral region of the spinal cord. Brain Res. 539:1991;254-262.
56. Yanagimoto M., Honda K., Goto Y., Negoro H. Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat. Brain Res. 733:1996;292-296.
57. Yells D.P., Hendricks S.E., Prendergast M.A. Lesions of the nucleus paragigantocellularis: Effects on mating behavior in male rats. Brain Res. 596:1992;73-79.