Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat

Neuroscience

Volumn 82, Issue 1, 1997, Pages 241-254

  Tang, Y ^a   Rampin, O ^b   Calas, A ^c   Facchinetti, P ^c   Giuliano, F ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CEMAGREF   (France)

^c CNRS   (France)

Author keywords

Dorsal gray commissure; Erection; Motoneurons; Sacral parasympathetic nucleus

Indexed keywords

HORSERADISH PEROXIDASE; OXYTOCIN; SEROTONIN; WHEAT GERM AGGLUTININ;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORPUS CAVERNOSUM; INNERVATION; LUMBOSACRAL SPINE; MALE; MOTONEURON; MUSCLE CONTRACTION; NONHUMAN; PARASYMPATHETIC NERVE CELL; PENIS ERECTION; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; RAT;

ANIMALS; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SMOOTH; NERVE FIBERS; OXYTOCIN; PENILE ERECTION; PENIS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPINAL CORD; SYNAPSES; WHEAT GERM AGGLUTININ-HORSERADISH PEROXIDASE CONJUGATE;

EID: 0030921545     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00290-X     Document Type: Article

References (55)

1. Allman H., Grillner S., Udo M. The effect of 5-HTP on the static fusimotor activity and the tonic stretch reflex of an extensor muscle. Brain Res. 27:1971;393-396.
2. Argiolas A. and Melis M. R. (1995) Oxytocin-induced penile erection: Role of nitric oxide. In Oxytocin, Cellular and Molecular Approaches in Medicine and Research, Advances in Experimental Medicine and Biology (eds Ivell R. and Russell J. R.), vol. 395, pp. 247-254. Plenum, New York.
3. Backman S. B., Henry J. L. Effects of oxytocin and vasopressin on thoracic sympathetic preganglionic neurones in the cat. Brain Res. Bull. 13:1984;679-684.
4. Basbaum A. I., Clanton C. H., Fields H. L. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J. comp. Neurol. 178:1978;209-224.
5. Basbaum A. I., Fields H. L. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J. comp. Neurol. 187:1979;513-532.
6. Basbaum A. I., Fields H. L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A. Rev. Neurosci. 7:1984;307-338.
7. Buijs R. M., Swaab D. F., Dogterom J., Van Leeuwen F. W. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Cell Tiss. Res. 186:1978;423-433.
8. Collins III W. F., Erichsen J. T., Rose R. D. Pudendal motor and premotor neurons in the male rat: a WGA transneuronal study. J. comp. Neurol. 308:1991;28-41.
9. Dahlström A., Fuxe K. The distribution of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine level of bulbospinal neuron systems. Acta physiol. scand. 64(Suppl. 247):1965;5-36.
10. Desaulles E., Reiter M. K., Feltz P. Electrophysiological evidence for oxytocin receptors on sympathetic preganglionic neurones - an in vitro study on the neonatal rat. Brain Res. 699:1995;139-142.
11. Gilbey M. P., Coote J. H., Fleetwood-Walker S., Peterson D. F. The influence of the paraventriculo-spinal pathway, and oxytocin and vasopressin on sympathetic preganglionic neurones. Brain Res. 251:1982;283-290.
12. Giuliano F., Rampin O., Benoit G., Jardin A. Neural control of penile erection. Urol. Clin. North Am. 22:1995;747-766.
13. Guan X. B., McVary K. T., McKenna K. E. Identification of 5-HT receptor subtypes involved in sexual reflexes in the spinal cord of male rat. Soc. Neurosci. Abstr. 21:1995;1875.
14. Hancock M. B., Peveto C. A. Preganglionic neurons in the sacral spinal cord of the rat: an HRP study. Neurosci. Lett. 11:1979;1-5.
15. Hancock M. B., Peveto C. A. A preganglionic autonomic nucleus in the dorsal gray commissure of the lumbar spinal cord of the rat. J. comp. Neurol. 183:1979;65-72.
16. Hermann G. E., Holmes G. M., Bresnahan J. C., Beattie M. S., Rogers R. C. Descending projections of the nucleus raphe obscurus (nRO); possible anatomical basis of role in lumbosacral reflexes. Soc. Neurosci. Abstr. 21:1995;1200.
17. Holmes G. M., Chapple W. D., Leipheimer R. E., Sachs B. D. Electromyographic analysis of male rat perineal muscles during copulation and reflexive erections. Physiol. Behav. 49:1991;1235-1246.
18. Hosoya Y., Sugiura Y., Okado N., Loewy A. D., Kohno K. Descending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat. Expl Brain Res. 85:1991;10-20.
19. Kurtz R. G., Santos R. Supraspinal influences on the penile reflexes of the male rat: a comparison of the effects of copulation, spinal transection and cortical spreading depression. Horm. Behav. 12:1979;73-94.
20. Lee R. L., Smith E. R., Mas M., Davidson J. M. Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats. Physiol. Behav. 47:1990;665-669.
21. Liu Y. C., Salamone J. D., Sachs B. D. Differential role of three brain regions (MPOA, PVH, and NPGi) in rat erectile function. Soc. Neurosci. Abstr. 21:1995;1464.
22. Llewellyn-Smith I. J., Pilowsky P. and Minson J. B. (1992) Retrograde tracers for light and electron microscopy. In Experimental Neuroanatomy, A Practical Approach (ed. Bolam J. P.), Chap. 2, pp. 31-59. IRL Press, Oxford.
23. Marlier L., Teilhac J. R., Cerruti C., Privat A. Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain Res. 550:1991;15-23.
24. Marson L., McKenna K. E. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Expl Brain Res. 88:1992;313-320.
25. Marson L., List M. S., McKenna K. E. Lesions of the nucleus paragigantocellularis alter ex copula penile reflexes. Brain Res. 592:1992;187-192.
26. Marson L., McKenna K. E. Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharmac. Biochem. Behav. 47:1994;883-888.
27. McKenna K. E., Nadelhaft I. The organization of the pudendal nerve in the male and female rat. J. comp. Neurol. 248:1986;532-549.
28. Mas M., Zahradnik M. A., Martino V., Davidson J. M. Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes. Brain Res. 342:1985;128-134.
29. Mathes C. W., Smith E. R., Popa B. R., Davidson J. M. Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats. Pharmac. Biochem. Behav. 36:1990;63-68.
30. Meisel R. L. and Sachs B. D. (1994) The physiology of male sexual behavior. In The Physiology of Reproduction (eds Knobil E. and Neill J. D.), 2nd edn, Chap. 35, pp. 3-105. Raven, New York.
31. Micevych P. E., Coquelin A., Arnold A. P. Immunohistochemical distribution of substance P, serotonin, and methionine enkephalin in sexually dimorphic nuclei of the rat lumbar spinal cord. J. comp. Neurol. 248:1986;235-244.
32. Myslinski N. R., Anderson E. G. The effect of serotonin precursors on alpha- and gamma-motoneuron activity. J. Pharmac. exp. Ther. 204:1978;19-26.
33. Nadelhaft I., Booth A. M. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J. comp. Neurol. 226:1984;238-245.
34. Newton B. W., Hamill R. W. Immunohistochemical distribution of serotonin in spinal autonomic nuclei: I. Fiber patterns in the adult rat. J. comp. Neurol. 279:1989;68-81.
35. Nilaver G., Zimmerman E. A., Wilkins J., Michaels J., Hoffman D., Silverman A. J. Magnocellular hypothalamic projections to the lower brainstem and spinal cord of the rat. Neuroendocrinology. 30:1980;150-158.
36. Pescatori E. S., Calabro A., Artibani W., Pagano F., Triban C., Italiano G. Electrical stimulation of the dorsal nerve of the penis evokes reflex tonic erections of the penile body and reflex ejaculatory responses in the spinal rat. J. Urol. 149:1993;627-632.
37. Peshori K. R., Erichsen J. T., Collins III W. F. Differences in the connectivity of rat pudendal motor nuclei as revealed by retrograde transneuronal transport of wheat germ agglutinin. J. comp. Neurol. 353:1995;119-128.
38. Rampin O., Gougis S., Giuliano F., Rousseau J. P. Stimulation of the dorsal nerve of the penis increases c-fos expression in spinal neurons in the rat. Soc. Neurosci. Abstr. 12:1995;1876.
39. Reiter M. K., Kremarik P., Freund-Mercier M. J., Stoeckel M. E., Desaulles E., Feltz P. Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur. J. Neurosci. 6:1994;98-104.
40. Rose R. D., Collins III W. F. Crossing dendrites may be a substrate for synchronized activation of penile motoneurons. Brain Res. 337:1985;373-377.
41. Rousselot P., Papadopoulos G., Merighi A., Poulain D. A., Theodosis D. T. Oxytocinergic innervation of the rat spinal cord. Brain Res. 529:1990;178-184.
42. Sachs B. D., Garinello L. D. Hypothetical pacemaker regulating penile reflexes in rats: evidence from transection of spinal cord and dorsal penile nerves. J. comp. physiol. Psychol. 94:1980;530-535.
43. Schmidt M. H., Schmidt H. S. The ischiocavernosus and bulbospongiosus muscles in mammalian penile rigidity. Sleep. 16:1993;171-183.
44. Schoenen J., Lotstra F., Vierendeels G., Reznik M., Vanderhaeghen J. J. Substance P, enkephalins, somatostatin, cholecystokinin, oxytocin, and vasopressin in human spinal cord. Neurology. 35:1985;881-890.
45. Schroder H. D. Organization of the motoneurons innervating the pelvic muscles of the male rat. J. comp. Neurol. 192:1980;567-587.
46. Sermasi E., Coote J. H. Oxytocin acts at V1 receptors to excite sympathetic preganglionic neurones in neonate rat spinal cord in vitro. Brain Res. 647:1994;323-332.
47. Skajerberg R., Björklund A. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat. Neuroscience. 15:1985;445-480.
48. Steers W. D., DeGroat W. C. Effects of m-chlorophenylpiperazine on penile and bladder function in rats. Am. J. Physiol. 257:1989;R1441-R1449.
49. Steinbusch H. Distribution of serotonin-immunoreactivity in the central nervous system of the rat cell bodies and terminals. Neuroscience. 6:1981;557-618.
50. Swanson L. W., McKellar S. The distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. J. comp. Neurol. 188:1979;87-106.
51. Tashiro T., Satoda T., Matsushima R., Mizuno N. Convergence of serotonin-, enkephalin- and substance P-like immunoreactive afferent fibers on single pudendal motoneurons in Onuf's nucleus of the cat: a light microscope study combining the triple immunocytochemical staining technique with the retrograde HRP-tracing method. Brain Res. 481:1989;392-398.
52. Theodosis D. T. Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus. Nature. 313:1985;682-684.
53. 1C/2 binding sites in the rat spinal cord. Neuroscience. 55:1993;235-252.
54. Tramu G., Pillez A., Leonardelli J. Serotonin axons of the ependyma and circumventricular organs in the forebrain of the guinea-pig. Cell Tiss. Res. 228:1983;297-311.
55. Véronneau-Longueville F., Giuliano F., Rampin O., Freund-Mercier M. J., Calas A. Histoautoradiographical evidence for oxytocinergic (OT) receptors in the lumbosacral spinal cord of the male rat. Soc. Neurosci. Abstr. 22:1996;1052.