The oxytocin antagonist d(CH2)5 Tyr(ME)2-Orn8-vasotocin reduces non- contact penile erections in male rats

Neuroscience Letters

Volumn 265, Issue 3, 1999, Pages 171-174

  Melis, Maria Rosaria ^a   Spano, Maria Sabrina ^a   Succu, Salvatora ^b   Argiolas, Antonio ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

Author keywords

Nitric oxide; Non contact penile erections; Oxytocin; Oxytocin antagonists; Paraventricular nucleus of the hypothalamus; Rat

Indexed keywords

DEXTRO PENTAMETHYLTYROSYL 2 MERCAPTYL 8 ORNITHYLVASOTOCIN; N(G) NITROARGININE METHYL ESTER; OXYTOCIN ANTAGONIST; UNCLASSIFIED DRUG; VASOTOCIN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LATERAL VENTRICLE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; OXYTOCIN RELEASE; PENIS ERECTION; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEXUAL BEHAVIOR; THALAMUS MIDLINE NUCLEUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; MALE; MICROINJECTIONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PENILE ERECTION; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL BEHAVIOR, ANIMAL;

EID: 0033597196     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00236-0     Document Type: Article

References (20)

1. Argiolas A., Melis M.R. Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Prog. Neurobiol. 47:1995;235-255.
2. 8-vasotocin in rats. Pharmacol. Biochem. Behav. 33:1989;81-83.
3. 8-vasotocin antagonizes male copulatorybehaviour in rats. Eur. J. Pharmacol. 149:1988;389-392.
4. Bankowski K., Manning M., Seto J., Halder J., Sawyer W.H. Design and synthesis of potent in vivo antagonists of oxytocin. Int. J. Pept. Prot. Res. 16:1980;382-391.
5. Benelli A., Bertolini A., Poggioli R., Cavazzuti E., Calzà L.M., Giardino L., Arletti R. Nitric oxide is involved in male sexual behaviour of rats. Eur. J. Pharmacol. 294:1995;505-510.
6. Eaton R.C., Markowski V.F., Lumley L.A., Thompson J.T., Moses J., Hull E.M. D2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacol. Biochem. Behav. 39:1991;177-181.
7. Edwards D.A., Davis A.B. Deafferentation of the olfactory bulbs of male rat reduces erection to remote cues from females. Physiol. Behav. 62:1997;145-149.
8. Hughes A.M., Everitt B.J., Lightman S.L., Todd K. Oxytocin in the central nervous system and sexual behavior in male rats. Brain Res. 414:1987;133-137.
9. Hull E.M., Lumley L.A., Matuszewich L., Dominguez J., Moses J., Lorrain D.S. The roles of nitric oxide in sexual function of male rats. Neuropharmacology. 33:1994;1499-1504.
10. Kondo Y., Sachs B.D., Sakuma Y. Importance of the medial amygdala in rat penile erection evoked by remote stimuli from estrous females. Behav. Brain Res. 88:1997;153-160.
11. Liu Y.C., Salamone B.D., Sachs B.D. Lesions in medial preoptic area and bed nucleus of the stria terminalis: differential effects on copulatory behavior and noncontact erection in male rats. J. Neurosci. 17:1997;5245-5253.
12. Liu Y.C., Salamone B.D., Sachs B.D. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav. Neurosci. 111:1997;1361-1367.
13. Melis M.R., Stancampiano R., Argiolas A. Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacol. Biochem. Behav. 42:1992;61-66.
14. Melis M.R., Stancampiano R., Argiolas A. Penile erection and yawning induced by paraventricular NMDA injection in male rats are mediated by oxytocin. Pharmacol. Biochem. Behav. 48:1994;203-207.
15. Melis M.R., Succu S., Mauri A., Argiolas A. Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during non contact penile erections and copulation. Eur. J. Neurosci. 10:1998;1968-1974.
16. Melis M.R., Succu S., Spano M.S., Argiolas A. Morphine injected into the paraventricular nucleus of the hypothalamus prevents non-contact penile erections and copulation: involvement of nitric oxide. Eur. J. Neurosci. 11:1999.
17. Monaghan E.P., Arjomand J., Breedlove S.M. Brain lesions affect penile reflexes. Horm. Behav. 27:1993;122-131.
18. Pellegrino L.J., Cushman A.J. A Stereotaxic Atlas of the Rat Brain. 1971;Meredith, New York.
19. Sachs B.D. Erection evoked in male rats by airborne scent from estrous females. Physiol. Behav. 62:1997;921-924.
20. Sachs B.D., Akasofu K., Citro J.K., Daniels S.B., Natoli J.H. Non-contact stimulation from estrus females evokes penile erection in rats. Physiol. Behav. 55:1994;1073-1079.