Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: Involvement of nitric oxide

European Journal of Neuroscience

Volumn 11, Issue 6, 1999, Pages 1857-1864

  Melis, Maria Rosaria ^a   Succu, Salvatora ^b   Spano, Maria Sabrina ^a   Argiolas, Antonio ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR   (Italy)

Author keywords

Copulatory behaviour; Morphine; Nitric oxide; Noncontact penile erection; Paraventricular nucleus of the hypothalamus; Rat

Indexed keywords

KAPPA OPIATE RECEPTOR ANTAGONIST; MORPHINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NITRATE; NITRIC OXIDE; NITRITE; OPIATE; OPIATE ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; COPULATION; DIALYSATE; HYPOTHALAMUS; MALE; MICRODIALYSIS; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; THALAMUS MIDLINE NUCLEUS;

ANIMALS; BENZENEACETAMIDES; COPULATION; FEMALE; INJECTIONS; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NITRIC OXIDE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PENILE ERECTION; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL BEHAVIOR, ANIMAL;

EID: 0032969142     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00603.x     Document Type: Article

References (19)

1. 8-vasotocin in rats. Pharmacol. Biochem. Behav., 33, 81-83.
2. 8-vasotocin antagonizes male copulatory behaviour in rats. Eur. J. Pharmacol., 149, 389-392.
3. Argiolas, A. & Melis, M.R. (1995) Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Prog. Neurobiol., 47, 235-255.
4. Argiolas, A., Melis, M.R., Mauri, A. & Gessa, G.L. (1987) Paraventricular lesions prevent yawning and penile erection induced by apomorphine and oxytocin, but not by ACTH in rats. Brain Res., 421, 349-352.
5. Arletti, A., Calzà, L., Giardino, L., Benelli, A., Cavazzuti, E. & Bertolini, A. (1997) Sexual impotence is associated with a reduced production of oxytocin and an increased production of opioid peptides in the paraventricular nucleus of the hypothalamus. Neurosci. Lett., 233, 65-68.
6. Band, L.C. & Hull, E.M. (1990) Morphine and dynorphin (1-13) microinjected into the medial preoptic area and the nucleus accumbens: effects on sexual behavior in male rats. Brain Res., 524, 77-84.
7. Benelli, A., Bertolini, A., Poggioli, R., Cavazzuti, E., Calzà, L.M., Giardino, L. & Arletti, R. (1995) Nitric oxide is involved in male sexual behaviour of rats. Eur. J. Pharmacol., 294, 505-510.
8. Chen, K.K., Chan, S.H.H., Chang, L.S. & Chan, J.Y.H. (1997) Participation of the paraventricular nucleus of the hypothalamus in central regulation of penile erection in the rat. J. Urol., 158, 238-244.
9. Cushman, P. (1972) Sexual behavior in heroin addiction and methadone maintenance. NY State J. Med., 72, 1261-1266.
10. 2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats. Pharmacol. Biochem. Behav., 39, 177-181.
11. Edwards, D.A. & Davis, A.B. (1997). Deafferentation of the olfactory bulbs of male rats reduces erection to remote cues from females. Physiol. Behav., 62, 145-149.
12. Hughes, A.M., Everitt, B.J. & Herbert, J. (1990) Comparative effects of preoptic area infusions of opioid peptides, lesions and castration on sexual behavior in male rats: studies of instrumental behaviour, conditioned place preference and partner preference. Psychopharmacology, 102, 243-256.
13. Hughes, A.M., Everitt, B.J., Lightman, S.L. & Todd, K. (1987) Oxytocin in the central nervous system and sexual behavior in male rats. Brain Res., 414, 133-137.
14. Ignarro, L.J. (1990) Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev. Pharmacol. Toxicol., 30, 535-560.
15. 3H]U-69,593, a highly selective ligand for the opioid kappa receptor. Eur. J. Pharmacol., 109, 281-284.
16. Liu, Y.-C., Sachs, B.D. & Salomone, J.D. (1997a) Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol. Biochem. Behav., 60, 585-592.
17. Liu, Y.-C., Salamone, J.D. & Sachs, B.D. (1997b) Lesions in medial preoptic area and bed nucleus of the stria terminalis: differential effects on copulatory behavior and non-contact erection in male rats. J. Neurosci., 17, 5245-5253.
18. Liu, Y.-C., Salamone, J.D. & Sachs, B.D. (1997c) Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Behav. Neurosci., 111, 1361-1367.
19. Luo, D., Knezevich, S. & Vincent, S.R. (1993) N-methyl-D-aspartate-induced nitric oxide release: an in vivo microdialysis study. Neuroscience, 57, 897-900.