Central neuropharmacological agents and mechanisms in erectile dysfunction: The role of dopamine

Neuroscience and Biobehavioral Reviews

Volumn 24, Issue 5, 2000, Pages 561-569

  Heaton, Jeremy P W ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Apomorphine; Dopamine; Erectile dysfunction; Erection; Human; Penile erection; Rat; Receptor

Indexed keywords

APOMORPHINE; DOPAMINE; DOPAMINE RECEPTOR; NITRIC OXIDE; OXYTOCIN; SEROTONIN RECEPTOR; SILDENAFIL; STEROID HORMONE;

DOPAMINERGIC SYSTEM; ERECTILE DYSFUNCTION; HUMAN; MALE; NEUROPHARMACOLOGY; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; REVIEW; SEXUAL BEHAVIOR;

ANIMALS; DOPAMINE; HUMANS; IMPOTENCE; MALE; PENILE ERECTION; PSYCHOTROPIC DRUGS;

EID: 0034126707     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(00)00023-3     Document Type: Review

References (70)

1. Adams M.A., Banting J.D., Maurice D.H., Morales A., Heaton J.P. Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple and overlapping systems. Int J Impot Res. 9:(2):1997;85-91.
2. Ahlenius S., Larsson K. Specific involvement of central 5-HT1A receptors in the mediation of male rat ejaculatory behavior. Neurochem Res. 22:(8):1997;1065-1070.
3. Andersson K.E., Holmquist F. Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings. World J Urol. 12:(5):1994;249-261.
4. Andersson K.E., Stief C.G. Neurotransmission and the contraction and relaxation of penile erectile tissues. World J Urol. 15:(1):1997;14-20.
5. Argiolas A., Melis M.R., Mauri A., Gessa G.L. Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats. Brain Res. 421:(1-2):1987;349-352.
6. Bagdy G., Makara G.B. Paraventricular nucleus controls 5-HT2C receptor-mediated corticosterone and prolactin but not oxytocin and penile erection responses. Eur J Pharmacol. 275:(3):1995;301-305.
7. Berendsen H., Broekkamp C. Drug-induced penile erections in rats: indications of serotonin1B receptor mediation. Eur J Pharmacol. 135:1987;279-287.
8. Bernabe J., Rampin O., McKenna K.E. Spinal regulation of erection by oxytocin: a pharmacological approach in the rat. Soc Neurosci Abstr. 596:1997;2.
9. Bernabe J., Rampin O., Sachs B.D., Giuliano F. Intracavernous pressure during erection in rats: an integrative approach based on telemetric recording. Am J Physiol. 276:(2 (Pt 2)):1999;R441-R449.
10. Boolell M., Allen M.J., Ballard S.A., Gepi-Attee S., Muirhead G.J., Naylor A.M., Osterloh I.H., Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 8:(2):1996;47-52.
11. Crowley R.S., Amico J.A. Gonadal steroid modulation of oxytocin and vasopressin gene expression in the hypothalamus of the osmotically stimulated rat. Endocrinology. 133:(6):1993;2711-2718.
12. Davis A.M., Ward S.C., Selmanoff M., Herbison A.E., McCarthy M.M. Developmental sex differences in amino acid neurotransmitter levels in hypothalamic and limbic areas of rat brain. Neuroscience. 90:(4):1999;1471-1482.
13. Demchyshyn L.L., Sugamori K.S., Lee F.J., Hamadanizadeh S.A., Niznik H.B. The dopamine D1D receptor. Cloning and characterization of three pharmacologically distinct D1-like receptors from Gallus domesticus. J Biol Chem. 270:(8):1995;4005-4012.
14. Drolet G., Adams M., Heaton J. Evidence for the central sites of action of apomorphine-induced erections. Int J Imp Res. 8:1996;108.
15. Dudley C.A., Rajendren G., Moss R.L. Signal processing in the vomeronasal system: modulation of sexual behavior in the female rat. Crit Rev Neurobiol. 10:(3-4):1996;265-290.
16. Fredholm B.B., Oberg B., Rosell S. Vascular reactions in canine subcutaneous adipose tissue following prostaglandin E1 (PGE1). Acta Pharmacol Toxicol (Copenh). 25:(Suppl 4):1967;28.
17. Gerhart C.C., van Heerikhuizen H. Functional characteristics of heterogeneously expressed 5-HT receptors. Eur J Pharmacol. 334:1997;1-23.
18. Goldstein I., Lue T.F., Padma-Nathan H., Rosen R.C., Steers W.D., Wicker P.A. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med. 338:(20):1998;1397-1404.
19. Gommans J., Bouwknecht J.A., Hijzen T.H., Berendsen H.H., Broekkamp C.L., Maes R.A., Olivier B. Stimulus properties of fluvoxamine in a conditioned taste aversion procedure. Psychopharmacology (Berl). 140:(4):1998;496-502.
20. Hartman D.S., Lanau F. Diversity of dopamine receptors: new molecular and pharmacological developments. Pol J Pharmacol. 49:1997;191-199.
21. Heaton J. New classification system for erectile dysfunction therapies. J Androl. 19:(4):1998;399-404.
22. Heaton J.P., Morales A., Adams M.A., Johnston B., El-Rashidy R. Recovery of erectile function by the oral administration of apomorphine. Urology. 45:(2):1995;200-206.
23. Heaton J.P., Varrin S.J. Effects of castration and exogenous testosterone supplementation in an animal model of penile erection. J Urol. 151:(3):1994;797-800.
24. Hedlund H., Andersson K.E. Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery. J Urol. 134:(6):1985;1245-1250.
25. Hull E.M., Bitran D., Pehek E.A., Warner R.K., Band L.C., Holmes G.M. Dopaminergic control of male sex behavior in rats: effects of an intracerebrally-infused agonist. Brain Res 2. 370:(1):1986;73-81.
26. Hull E.M., Du J., Lorrain D.S., Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. J Neurosci. 15:(11):1995;7465-7471.
27. Hull E.M., Eaton R.C., Markowski V.P., Moses J., Lumley L.A., Loucks J.A. Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: implications for copulation. Life Sci. 51:(22):1992;1705-1713.
28. Hull E.M., Lorrain D.S., Du J., Matuszewich L., Lumley L.A., Putnam S.K., Moses J. Hormone-neurotransmitter interactions in the control of sexual behavior. Behav Brain Res 1. 105:(1):1999;105-116.
29. Hull E.M., Warner R.K., Bazzett T.J., Eaton R.C., Thompson J.T., Scaletta L.L. D2/D1 ratio in the medial preoptic area affects copulation of male rats. J Pharmacol Exp Ther. 251:(2):1989;422-427.
30. Insel T.R., Young L., Wang Z. Central oxytocin and reproductive behaviours. Rev Reprod. 2:(1):1997;28-37.
31. Junemann K.P., Persson-Junemann C., Tanagho E.A., Alken P. Neurophysiology of penile erection. Urol Res. 17:(4):1989;213-217.
32. Kelliher K.R., Liu Y.C., Baum M.J., Sachs B.D. Neuronal fos activation in olfactory bulb and forebrain of male rats having erections in the presence of inaccessible estrous females. Neuroscience. 92:(3):1999;1025-1033.
33. Kenakin T. The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol Rev. 48:1996;413.
34. Kolasa K., Consolo S., Costi P., Kleinrok Z., Zecca L. Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat. Pharmacol Biochem Behav. 51:1995;29-35.
35. Lavoisier P., Proulx J., Courtois F., De Carufel F., Durand L.G. Relationship between perineal muscle contractions, penile tumescence, and penile rigidity during nocturnal erections. J Urol. 139:(1):1988;176-179.
36. Lee E., Geyer M. Dopamine autoreceptor mediation of the effects of apomorphine on serotonin neurons. Pharmacol Biochem Behav. 21:1984;301-311.
37. Lee E., Geyer M. Selective effects of apomorphine on dorsal raphe neurons: a cytofluorimetric study. Brain Res Bull. 9:1982;719-725.
38. Lin C.S., Lau A., Bakircioglu E., Tu R., Wu F., Week S., Nunes L., Lue T.F. Analysis of neuronal nitric oxide synthase isoform expression and identification of human nNOS-mu. Biochem Biophys Res Commun. 253:(2):1998;388-394.
39. Linet O.I., Ogrinc F.G. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The Alprostadil Study Group. N Engl J Med 4. 334:(14):1996;873-877.
40. Liu Y.-C., Sachs B., Salamone J. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol Biochem Behav. 60:1998;585-592.
41. Livache T., Bazin H., Mathis G. Conducting polymers on microelectronic devices as tools for biological analyses. Clin Chim Acta. 278:(2):1998;171-176.
42. Lorrain D.S., Matuszewich L., Howard R.V., Du J., Hull E.M. Nitric oxide promotes medial preoptic dopamine release during male rat copulation. Neuroreport 20. 8:(1):1996;31-34.
43. Maeda N., Matsuoka N., Yamaguchi I. Role of the dopaminergic, serotonergic and cholinergic link in the expression of penile erection in rats. Jpn J Pharmacol. 66:1994;59-66.
44. Manzo J., Cruz M.R., Hernandez M.E., Pacheco P., Sachs B.D. Regulation of noncontact erection in rats by gonadal steroids. Horm Behav. 35:(3):1999;264-270.
45. Martinez-Pineiro L., Trigo-Rocha F., Hsu G.L., von Heyden B., Lue T.F., Tanagho E.A. Cyclic guanosine monophosphate mediates penile erection in the rat. Eur Urol. 24:(4):1993;492-499.
46. McClintock M.K. On the nature of mammalian and human pheromones. Ann N Y Acad Sci. 855:1998;390-392.
47. McGinnis M.Y., Mirth M.C., Zebrowski A.F., Dreifuss R.M. Critical exposure time for androgen activation of male sexual behavior in rats. Physiol Behav. 46:(2):1989;159-165.
48. Melis M., Argiolas A., Gessa G. Apomorphine-induced penile erection and yawning: site of action in brain. Brain Res. 415:1987;98-104.
49. Melis M., Argiolas A., Gessa G. Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system. Eur J Pharmacol. 164:1989;565-570.
50. Melis M.R., Argiolis A. Role of nitric oxide in the control of penile erection and yawning. Prog Neuropsychopharmacol Biol Psychiatry. 21:1997;899-922.
51. Melis M.R., Argiolas A., Stancampiano R., et al. Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats. Eur J Med. 182:1990;101-107.
52. Melis M.R., Spano M.S., Succu S., Argiolas A. The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci Lett. 265:(3):1999;171-174.
53. Melis M.R., Stancampiano R., Argiolas A. Hippocampal oxytocin mediates apomorphine-induced penile erection and yawning. Pharmacol Biochem Behav. 42:(1):1992;61-66.
54. Mills T.M., Dai Y., Stopper V.S., Lewis R.W. Androgenic maintenance of the erectile response in the rat. Steroids. 64:(9):1999;605-609.
55. Mong J.A., McCarthy M.M. Steroid-induced developmental plasticity in hypothalamic astrocytes: implications for synaptic patterning. J Neurobiol 15. 40:(4):1999;602-619.
56. Moses J., Hull E.M. A nitric oxide synthesis inhibitor administered into the medial preoptic area increases seminal emissions in an ex-copula reflex test. Pharmacol Biochem. Behav63:(3):1999;345-348.
57. Olivier B., van Oorschot R., Waldinger M.D. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol Suppl. 6:1998;S9-S14.
58. Padma-Nathan H., Auerbach S., Lewis R., Lewand M., Perdok R., The apomorphine study group. Efficacy and safety of apomorphine SL vs. placebo for male erectile dysfunction. J Urol. 161:(4):1999;S214.
59. Pehek E.A., Thompson J.T., Hull E.M. The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat. Brain Res 23. 500:(1-2):1989;325-332.
60. Pehek E.A., Warner R.K., Bazzett T.J., Bitran D., Band L.C., Eaton R.C., Hull E.M. Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats. Brain Res 8. 443:(1-2):1988;70-76.
61. Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic,noncholinergic neurotransmission. N Engl J Med. 326:(2):1992;90-94.
62. Rehman J., Kaynan A., Christ G., Valcic M., Maayani S., Melman A. Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain Res 13. 821:(2):1999;414-425.
63. Rosen R.C., Lane M.L., Menza M. Effects of SSRIs on sexual function: a critical review. J Clin Psychopharm. 19:1999;67-84.
64. Sam E. Pharmacokinetics, biodistribution and mode ofaction of apomorphine. 1997;182 Pharmaceutical Sciences: Leuven University Press.
65. Schwarz S., Pohl P. Steroids and opioid receptors. J Steroid Biochem Mol Biol. 48:(4):1994;391-402.
66. Segraves R.T., Bari M., Segraves K., Spirnak P. Effect of apomorphine on penile tumescence in men with psychogenic impotence. J Urol. 145:(6):1991;1174-1175.
67. Shepherd G.M., Mirsky J.S., Healy M.D., Singer M.S., Skoufos E., Hines M.S., Nadkarni P.M., Miller P.L. The human brain project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data. Trends Neurosci. 21:(11):1998;460-468.
68. Sokoloff P., Diaz J., Levesque D., Pilon C., Dimitriadou V., Griffon N., Lammers C.H., Martres M.P., Schwartz J.C. Novel dopamine receptor subtypes as targets for antipsychotic drugs. Ann N Y Acad Sci. 757:1995;278-292.
69. Warner R.K., Thompson J.T., Markowski V.P., Loucks J.A., Bazzett T.J., Eaton R.C., Hull E.M. Microinjection of the dopamine antagonist cis-flupenthixol into the MPOA impairs copulation, penile reflexes and sexual motivation in male rats. Brain Res 1. 540:(1-2):1991;177-182.
70. Wessells H., Fuciarelli K., Hansen J., Hadley M.E., Hruby V.J., Dorr R., Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol. 160:(2):1998;389-393.