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Volumn 1, Issue 1, 2001, Pages 66-72

Neurotrophic factors and neuropathic pain

Author keywords

Analgesia; BDNF; Dorsal root ganglia; Growth factors; Neuropathic pain; NGF; Spinal Nerve ligation

Indexed keywords

GDNF PROTEIN, HUMAN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

EID: 0035260258     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(01)00010-8     Document Type: Review
Times cited : (103)

References (53)
  • 1
    • 0032412213 scopus 로고    scopus 로고
    • Peripheral neuropathy with nucleoside antiretrovirals: Risk factors, incidence and management
    • Moyle GJ, Sadler M. Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management. Drug Saf. 19:1998;481-494.
    • (1998) Drug Saf , vol.19 , pp. 481-494
    • Moyle, G.J.1    Sadler, M.2
  • 2
    • 0025167399 scopus 로고
    • A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
    • Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 43:1990;205-218.
    • (1990) Pain , vol.43 , pp. 205-218
    • Seltzer, Z.1    Dubner, R.2    Shir, Y.3
  • 3
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 4
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 5
    • 0024511376 scopus 로고
    • Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block
    • Price DD, Bennett GJ, Rafii A. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block. Pain. 36:1989;273-288.
    • (1989) Pain , vol.36 , pp. 273-288
    • Price, D.D.1    Bennett, G.J.2    Rafii, A.3
  • 6
    • 0030044429 scopus 로고    scopus 로고
    • Neurotrophins cause a new sensation
    • Snider WD, Wright DE. Neurotrophins cause a new sensation. Neuron. 16:1996;229-232.
    • (1996) Neuron , vol.16 , pp. 229-232
    • Snider, W.D.1    Wright, D.E.2
  • 7
    • 0033757828 scopus 로고    scopus 로고
    • Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
    • Patel TD, Jackman A, Rice FL, Kucera J, Snider WD. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron. 25:2000;345-357.
    • (2000) Neuron , vol.25 , pp. 345-357
    • Patel, T.D.1    Jackman, A.2    Rice, F.L.3    Kucera, J.4    Snider, W.D.5
  • 11
    • 0030267280 scopus 로고    scopus 로고
    • NGF but not NT-3 or BDNF prevents the A fiber sprouting into lamina II of the spinal cord that occurs following axotomy
    • Bennett DL, French J, Priestley JV, McMahon SB. NGF but not NT-3 or BDNF prevents the A fiber sprouting into lamina II of the spinal cord that occurs following axotomy. Mol Cell Neurosci. 8:1996;211-220.
    • (1996) Mol Cell Neurosci , vol.8 , pp. 211-220
    • Bennett, D.L.1    French, J.2    Priestley, J.V.3    McMahon, S.B.4
  • 12
    • 0032522908 scopus 로고    scopus 로고
    • A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury
    • Bennett DL, Michael GJ, Ramachandran N, Munson JB, Averill S, Yan Q, McMahon SB, Priestley JV. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J Neurosci. 18:1998;3059-3072.
    • (1998) J Neurosci , vol.18 , pp. 3059-3072
    • Bennett, D.L.1    Michael, G.J.2    Ramachandran, N.3    Munson, J.B.4    Averill, S.5    Yan, Q.6    McMahon, S.B.7    Priestley, J.V.8
  • 13
    • 0034613153 scopus 로고    scopus 로고
    • Potent analgesic effects of GDNF in neuropathic pain states
    • This study describes the analgesic effects of GDNF in two animal models of neuropathic pain, demonstrating its ability to reverse an established neuropathy. GDNF also reduces ectopic discharges in damaged sensory neurons, which is thought to be a result of its regulation of several sodium channel subunits
    • Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB. Potent analgesic effects of GDNF in neuropathic pain states. Science. 290:2000;124-127. This study describes the analgesic effects of GDNF in two animal models of neuropathic pain, demonstrating its ability to reverse an established neuropathy. GDNF also reduces ectopic discharges in damaged sensory neurons, which is thought to be a result of its regulation of several sodium channel subunits.
    • (2000) Science , vol.290 , pp. 124-127
    • Boucher, T.J.1    Okuse, K.2    Bennett, D.L.3    Munson, J.B.4    Wood, J.N.5    McMahon, S.B.6
  • 14
    • 0032428176 scopus 로고    scopus 로고
    • NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons
    • Bradbury EJ, King VR, Simmons LJ, Priestley JV, McMahon SB. NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. Eur J Neurosci. 10:1998;3058-3068.
    • (1998) Eur J Neurosci , vol.10 , pp. 3058-3068
    • Bradbury, E.J.1    King, V.R.2    Simmons, L.J.3    Priestley, J.V.4    McMahon, S.B.5
  • 15
    • 0034688281 scopus 로고    scopus 로고
    • Functional regeneration of sensory axons into the adult spinal cord
    • Ramer MS, Priestley JV, McMahon SB. Functional regeneration of sensory axons into the adult spinal cord. Nature. 403:2000;312-316.
    • (2000) Nature , vol.403 , pp. 312-316
    • Ramer, M.S.1    Priestley, J.V.2    McMahon, S.B.3
  • 16
    • 0034175686 scopus 로고    scopus 로고
    • Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury
    • This study describes the development of ectopic discharges in damaged myelinated afferents following spinal nerve ligation. This activity increase correlates with the onset of mechanical allodynia, which occurs in the absence of spontaneous activity in damaged C fibres
    • Liu CN, Wall PD, Ben-Dor E, Michaelis M, Amir R, Devor M. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain. 85:2000;503-521. This study describes the development of ectopic discharges in damaged myelinated afferents following spinal nerve ligation. This activity increase correlates with the onset of mechanical allodynia, which occurs in the absence of spontaneous activity in damaged C fibres.
    • (2000) Pain , vol.85 , pp. 503-521
    • Liu, C.N.1    Wall, P.D.2    Ben-Dor, E.3    Michaelis, M.4    Amir, R.5    Devor, M.6
  • 17
    • 0023924048 scopus 로고
    • Myelinated afferents signal the hyperalgesia associated with nerve injury
    • Campbell JN, Raja SN, Meyer RA, Mackinnon SE. Myelinated afferents signal the hyperalgesia associated with nerve injury. Pain. 32:1988;89-94.
    • (1988) Pain , vol.32 , pp. 89-94
    • Campbell, J.N.1    Raja, S.N.2    Meyer, R.A.3    Mackinnon, S.E.4
  • 18
    • 0033979426 scopus 로고    scopus 로고
    • Spinal nerve ligation: What to blame for the pain and why
    • An excellent overview of the possible roles of intact and spared A- and C-type afferents in maintaining neuropathy. The authors discuss the conflicting reports on the relevance of damaged afferents to neuropathic pain
    • Gold MS. Spinal nerve ligation: what to blame for the pain and why. Pain. 84:2000;117-120. An excellent overview of the possible roles of intact and spared A- and C-type afferents in maintaining neuropathy. The authors discuss the conflicting reports on the relevance of damaged afferents to neuropathic pain.
    • (2000) Pain , vol.84 , pp. 117-120
    • Gold, M.S.1
  • 19
    • 0001937431 scopus 로고    scopus 로고
    • Pathophysiology of damaged nerves in relation to chronic pain
    • P.D. Wall, & R. Melzack. London: Churchill Livingstone
    • Devor M, Seltzer Z. Pathophysiology of damaged nerves in relation to chronic pain. Wall PD, Melzack R. Textbook of Pain. 4 edn:1999;129-164 Churchill Livingstone, London.
    • (1999) Textbook of Pain 4 Edn , pp. 129-164
    • Devor, M.1    Seltzer, Z.2
  • 20
    • 0027477465 scopus 로고
    • Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
    • Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 52:1993;259-285.
    • (1993) Pain , vol.52 , pp. 259-285
    • Coderre, T.J.1    Katz, J.2    Vaccarino, A.L.3    Melzack, R.4
  • 21
    • 0033957307 scopus 로고    scopus 로고
    • Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats
    • Liu X, Eschenfelder S, Blenk K-H, Janig W, Habler H-J. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. Pain. 84:2000;309-318.
    • (2000) Pain , vol.84 , pp. 309-318
    • Liu, X.1    Eschenfelder, S.2    Blenk K-H3    Janig, W.4    Habler H-J5
  • 22
    • 0027210640 scopus 로고
    • Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model
    • Sheen K, Chung JM. Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model. Brain Res. 610:1993;62-68.
    • (1993) Brain Res , vol.610 , pp. 62-68
    • Sheen, K.1    Chung, J.M.2
  • 23
    • 0030060949 scopus 로고    scopus 로고
    • Contributions of injured and intact afferents to neuropathic pain in an experimental rat model
    • Yoon YW, Na HS, Chung JM. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain. 64:1996;27-36.
    • (1996) Pain , vol.64 , pp. 27-36
    • Yoon, Y.W.1    Na, H.S.2    Chung, J.M.3
  • 24
    • 0034175661 scopus 로고    scopus 로고
    • Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers
    • Li Y, Dorsi MJ, Meyer RA, Belzberg AJ. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain. 85:2000;493-502.
    • (2000) Pain , vol.85 , pp. 493-502
    • Li, Y.1    Dorsi, M.J.2    Meyer, R.A.3    Belzberg, A.J.4
  • 25
    • 0032978701 scopus 로고    scopus 로고
    • The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior
    • Colburn RW, Rickman AJ, DeLeo JA. The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol. 157:1999;289-304.
    • (1999) Exp Neurol , vol.157 , pp. 289-304
    • Colburn, R.W.1    Rickman, A.J.2    Deleo, J.A.3
  • 26
    • 0033983432 scopus 로고    scopus 로고
    • Abnormal substance P release from the spinal cord following injury to primary sensory neurons
    • Malcangio M, Ramer MS, Jones MG, McMahon SB. Abnormal substance P release from the spinal cord following injury to primary sensory neurons. Eur J Neurosci. 12:2000;397-399.
    • (2000) Eur J Neurosci , vol.12 , pp. 397-399
    • Malcangio, M.1    Ramer, M.S.2    Jones, M.G.3    McMahon, S.B.4
  • 27
    • 0029954092 scopus 로고    scopus 로고
    • Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons
    • Neumann S, Doubell TP, Leslie T, Woolf CJ. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature. 384:1996;360-364.
    • (1996) Nature , vol.384 , pp. 360-364
    • Neumann, S.1    Doubell, T.P.2    Leslie, T.3    Woolf, C.J.4
  • 28
    • 0030247053 scopus 로고    scopus 로고
    • Progressive tactile hypersensitivity: An inflammation-induced incremental increase in the excitability of the spinal cord
    • Ma QP, Woolf CJ. Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord. Pain. 67:1996;97-106.
    • (1996) Pain , vol.67 , pp. 97-106
    • Ma, Q.P.1    Woolf, C.J.2
  • 29
    • 0032878436 scopus 로고    scopus 로고
    • Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei
    • Michael GJ, Averill S, Shortland PJ, Yan Q, Priestley JV. Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur J Neurosci. 11:1999;3539-3551.
    • (1999) Eur J Neurosci , vol.11 , pp. 3539-3551
    • Michael, G.J.1    Averill, S.2    Shortland, P.J.3    Yan, Q.4    Priestley, J.V.5
  • 30
    • 0033040484 scopus 로고    scopus 로고
    • Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat
    • Zhou XF, Chie ET, Deng YS, Zhong JH, Xue Q, Rush RA, Xian CJ. Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience. 92:1999;841-853.
    • (1999) Neuroscience , vol.92 , pp. 841-853
    • Zhou, X.F.1    Chie, E.T.2    Deng, Y.S.3    Zhong, J.H.4    Xue, Q.5    Rush, R.A.6    Xian, C.J.7
  • 33
    • 0028194876 scopus 로고
    • Distribution of c-fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve
    • Molander C, Hongpaisan J, Persson JK. Distribution of c-fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve. Brain Res. 644:1994;74-82.
    • (1994) Brain Res , vol.644 , pp. 74-82
    • Molander, C.1    Hongpaisan, J.2    Persson, J.K.3
  • 34
    • 0033535120 scopus 로고    scopus 로고
    • Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: Possible implications for sensory sprouting
    • This study shows that small diameter neurones begin to transport cholera toxin B after nerve damage, and this de novo transport might confound interpretation of labelling experiments using this marker. Unfortunately, many studies sprouting Aβ fibres have used this methods
    • Tong YG, Wang HF, Ju G, Grant G, Hokfelt T, Zhang X. Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: possible implications for sensory sprouting. J Comp Neurol. 404:1999;143-158. This study shows that small diameter neurones begin to transport cholera toxin B after nerve damage, and this de novo transport might confound interpretation of labelling experiments using this marker. Unfortunately, many studies sprouting Aβ fibres have used this methods.
    • (1999) J Comp Neurol , vol.404 , pp. 143-158
    • Tong, Y.G.1    Wang, H.F.2    Ju, G.3    Grant, G.4    Hokfelt, T.5    Zhang, X.6
  • 35
    • 0026555273 scopus 로고
    • Peripheral nerve injury triggers central sprouting of myelinated afferents
    • Woolf CJ, Shortland P, Coggeshall RE. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature. 355:1992;75-78.
    • (1992) Nature , vol.355 , pp. 75-78
    • Woolf, C.J.1    Shortland, P.2    Coggeshall, R.E.3
  • 36
    • 0034652122 scopus 로고    scopus 로고
    • Synaptic reorganization in the substantia gelatinosa after peripheral nerve neuroma formation: Aberrant innervation of lamina II neurons by Abeta afferents
    • An elegant study demonstrating unequivocally the aberrant sprouting of A fibres into the superficial laminae. After nerve injury there is a large increase in the proportion of lamina II neurons that show monosynaptic activation from A fibre stimulation, and tracer applied to single A fibres shows terminal arbors extending into this region
    • Kohama I, Ishikawa K, Kocsis JD. Synaptic reorganization in the substantia gelatinosa after peripheral nerve neuroma formation: aberrant innervation of lamina II neurons by Abeta afferents. J Neurosci. 20:2000;1538-1549. An elegant study demonstrating unequivocally the aberrant sprouting of A fibres into the superficial laminae. After nerve injury there is a large increase in the proportion of lamina II neurons that show monosynaptic activation from A fibre stimulation, and tracer applied to single A fibres shows terminal arbors extending into this region.
    • (2000) J Neurosci , vol.20 , pp. 1538-1549
    • Kohama, I.1    Ishikawa, K.2    Kocsis, J.D.3
  • 37
    • 0032746351 scopus 로고    scopus 로고
    • The molecular pathophysiology of pain: Abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons
    • Waxman SG. The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons. Pain. 6:(Suppl.):1999;S133-S140.
    • (1999) Pain , vol.6 , pp. 133-S140
    • Waxman, S.G.1
  • 38
    • 0030861765 scopus 로고    scopus 로고
    • Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons
    • Omana-Zapata I, Khabbaz MA, Hunter JC, Clarke DE, Bley KR. Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons. Pain. 72:1997;41-49.
    • (1997) Pain , vol.72 , pp. 41-49
    • Omana-Zapata, I.1    Khabbaz, M.A.2    Hunter, J.C.3    Clarke, D.E.4    Bley, K.R.5
  • 39
    • 0030997916 scopus 로고    scopus 로고
    • Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury
    • Cummins TR, Waxman SG. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci. 17:1997;3503-3514.
    • (1997) J Neurosci , vol.17 , pp. 3503-3514
    • Cummins, T.R.1    Waxman, S.G.2
  • 40
    • 0033586628 scopus 로고    scopus 로고
    • Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
    • Fjell J, Cummins TR, Dib-Hajj SD, Fried K, Black JA, Waxman SG. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Brain Res Mol Brain Res. 67:1999;267-282.
    • (1999) Brain Res Mol Brain Res , vol.67 , pp. 267-282
    • Fjell, J.1    Cummins, T.R.2    Dib-Hajj, S.D.3    Fried, K.4    Black, J.A.5    Waxman, S.G.6
  • 41
    • 0034307559 scopus 로고    scopus 로고
    • Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy
    • Sleeper AA, Cummins TR, Dib-Hajj SD, Hormuzdiar W, Tyrrell L, Waxman SG, Black JA. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy. J Neurosci. 20:2000;7279-7289.
    • (2000) J Neurosci , vol.20 , pp. 7279-7289
    • Sleeper, A.A.1    Cummins, T.R.2    Dib-Hajj, S.D.3    Hormuzdiar, W.4    Tyrrell, L.5    Waxman, S.G.6    Black, J.A.7
  • 42
    • 0033932306 scopus 로고    scopus 로고
    • Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: Relation to neuropathic pain
    • Liu CN, Michaelis M, Amir R, Devor M. Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. J Neurophysiol. 84:2000;205-215.
    • (2000) J Neurophysiol , vol.84 , pp. 205-215
    • Liu, C.N.1    Michaelis, M.2    Amir, R.3    Devor, M.4
  • 44
    • 0032988286 scopus 로고    scopus 로고
    • Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey
    • This study demonstrates the onset of spontaneous activity in spared C fibre afferents following damage to their neighbours. This low-level barrage may be critical in maintaining some aspects of neuropathy, such as thermal hyperalgesia
    • Ali Z, Ringkamp M, Hartke TV, Chien HF, Flavahan NA, Campbell JN, Meyer RA. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J Neurophysiol. 81:1999;455-466. This study demonstrates the onset of spontaneous activity in spared C fibre afferents following damage to their neighbours. This low-level barrage may be critical in maintaining some aspects of neuropathy, such as thermal hyperalgesia.
    • (1999) J Neurophysiol , vol.81 , pp. 455-466
    • Ali, Z.1    Ringkamp, M.2    Hartke, T.V.3    Chien, H.F.4    Flavahan, N.A.5    Campbell, J.N.6    Meyer, R.A.7
  • 45
    • 0034175624 scopus 로고    scopus 로고
    • Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion
    • Michaelis M, Liu X, Janig W. Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J Neurosci. 20:2000;2742-2748.
    • (2000) J Neurosci , vol.20 , pp. 2742-2748
    • Michaelis, M.1    Liu, X.2    Janig, W.3
  • 48
    • 0033053094 scopus 로고    scopus 로고
    • Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats
    • Ossipov MH, Bian D, Malan TPJ, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain. 79:1999;127-133.
    • (1999) Pain , vol.79 , pp. 127-133
    • Ossipov, M.H.1    Bian, D.2    Malan, T.P.J.3    Lai, J.4    Porreca, F.5
  • 50
    • 0033551585 scopus 로고    scopus 로고
    • Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons
    • Ogun-Muyiwa P, Helliwell R, McIntyre P, Winter J. Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons. Neuroreport. 10:1999;2107-2111.
    • (1999) Neuroreport , vol.10 , pp. 2107-2111
    • Ogun-Muyiwa, P.1    Helliwell, R.2    McIntyre, P.3    Winter, J.4
  • 51
    • 0029085192 scopus 로고
    • The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
    • McMahon SB, Bennett DL, Priestley JV, Shelton DL. The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule. Nat Med. 1:1995;774-780.
    • (1995) Nat Med , vol.1 , pp. 774-780
    • McMahon, S.B.1    Bennett, D.L.2    Priestley, J.V.3    Shelton, D.L.4
  • 52
    • 0033176025 scopus 로고    scopus 로고
    • Causes and consequences of sympathetic basket formation in dorsal root ganglia
    • Ramer MS, Thompson SW, McMahon SB. Causes and consequences of sympathetic basket formation in dorsal root ganglia. Pain. 6:(Suppl.):1999;S111-S120.
    • (1999) Pain , vol.6 , pp. 111-S120
    • Ramer, M.S.1    Thompson, S.W.2    McMahon, S.B.3
  • 53
    • 0034646215 scopus 로고    scopus 로고
    • A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291
    • [Published erratum appears in Neurology 2000, 55:162.] A recent clinical trial showing positive effects of NGF treatment on HIV-associated painful neuropathy. Although NGF treatment resulted in injection-site hyperalgesia in some patients (thus unblinding these subjects), subsequent removal of these from the outcome measure analysis still left a significant positive effect on pain
    • McArthur JC, Yiannoutsos C, Simpson DM, Adornato BT, Singer EJ, Hollander H, Marra C, Rubin M, Cohen BA, Tucker T, et al. A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291. Neurology. 54:2000;1080-1088. [Published erratum appears in Neurology 2000, 55:162.] A recent clinical trial showing positive effects of NGF treatment on HIV-associated painful neuropathy. Although NGF treatment resulted in injection-site hyperalgesia in some patients (thus unblinding these subjects), subsequent removal of these from the outcome measure analysis still left a significant positive effect on pain.
    • (2000) Neurology , vol.54 , pp. 1080-1088
    • McArthur, J.C.1    Yiannoutsos, C.2    Simpson, D.M.3    Adornato, B.T.4    Singer, E.J.5    Hollander, H.6    Marra, C.7    Rubin, M.8    Cohen, B.A.9    Tucker, T.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.