The molecular pathophysiology of pain: Abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons

Pain

Volumn 82, Issue SUPPL.1, 1999, Pages

  Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

DRG neuron; Hyperexcitability; Inflammation; Ion channels; Nerve injury

Indexed keywords

SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE EXPRESSION; INFLAMMATION; NERVE CELL EXCITABILITY; NERVE INJURY; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REVIEW; SENSORY NERVE CELL; SPINAL GANGLION; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; NEURONS, AFFERENT; PAIN; SODIUM CHANNELS;

EID: 0032746351     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(99)00147-5     Document Type: Article

References (60)

1. Aguayo LG, White G. Effects of nerve growth factor on TTX- and capsaicin-sensitivity in adult rat sensory neurons. Brain Res 1992;570:61-67.
2. Akopian AN, Sivilotti L, Wood JN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. J Biol Chem 1996;271:5953-5956.
3. Black JA, Dib-Hajj S, McNabola K, Jeste S, Rizzo MA, Kocsis JD, Waxman SG. Spinal sensory neurons express multiple sodium channel α-subunit mRNAs. Molec Brain Res 1996;43:117-132.
4. + channel III and SNS gene expression in spinal sensory neurons. NeuroRep 1997;8:2331-2335.
5. Brock JA, McLachlan EM, Belmonte C. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig comes. J Physiol 1998;512:211-217.
6. Caffrey JM, Eng DL, Black JA, Waxman SG, Kocsis JD. Three types of sodium channels in adult rat dorsal root ganglion neurons. Brain Res 1992;592:283-297.
7. Chabal C, Russell LC, Burchiel KJ. The effect of intravenous lidocaine, tocainide. and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain 1989;38:333-338.
8. Cummins TR, Waxman SG. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neuroscience 1997;17:3503-3514.
9. Cummins TR, Howe JR, Waxman SG. Slow closed-state inactivation: A novel mechanism underlying ramp currents in cells expressing the hNE/ PN1 sodium channel. J Neuroscience 1998;18:9607-9619.
10. Devor M, Keller CH, Deerinck TJ, Ellisman MH. Na channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus. Neuroscience Lett 1989;102:149-154.
11. Devor M, Wall PD, Catalan N. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 1992;48:261-268.
12. Devor M. The pathophysiology of damaged peripheral nerves. In: Wall PD, Melzack R, editors. Textbook of Pain, 2nd ed. Edinburgh: Churchill Livingstone, 1994. pp. 79-101.
13. Dib-Hajj S, Black JA, Felts P, Waxman SG. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy. Proc Natl Acad Sci USA 1996;93:14950-14954.
14. Dib-Hajj SD, Tyrrell L, Black JA, Waxman SG. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci 1998;95:8963-8969.
15. Dib-Hajj SD, Black JA, Cummins TR, Kenney AM, Kocsis JD, Waxman SG. Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo. J Neurophysiol 1998;79:2668-2678.
16. Eccles JC, Libet B, Young RR. The behavior of chromatolysed motoneurons studied by intracellular recording. J Physiol (Lond) 1958;143:11-40.
17. Elliott AA, Elliott JR. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J Physiol (Lond) 1993;463:39-56.
18. England JD, Gamboni F, Ferguson MA, Levinson SR. Sodium channels accumulate at the tips of injured axons. Muscle Nerve 1994; 17:593-598.
19. England S, Bevan S, Docherty RJ. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol (Lond) 1996;495:429-440.
20. Felts PA, Black JA, Dib-Hajj SD, Waxman SG. NaG: a sodium channel-like mRNA shared by Schwann cells and other neural crest derivatives. Glia 1997;21:269-277.
21. Fjell J. Cummins TR, Dib-Hajj SD, Fried K, Black JA, Waxman SG. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Molec Brain Res 1999;67:266-282.
22. Gautron S, Dos Santos G, Pinto-Henrique D, Koulkoff A, Gros F, Berwaldnetter Y. The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression. Proc Natl Acad Sci USA 1992;89:7272-7276.
23. Gold MS, Reichling DB, Shuster MJ, Levine JD. Hyperalgesic agents increase a tetrodotoxin-resistant Na current in nociceptors. Proc Natl Acad Sci USA 1996;93:1108-1112.
24. Gould III HJ, England JD, Liu ZP, Levinson SR. Rapid sodium channel augmentation in response to inflammation induced by complete Freund's adjuvant. Brain Res 1998;802:69-74.
25. Gurtu S, Smith PA. Electrophysiological characteristics of hamster dorsal root ganglion cells and their response to axotomy. J Neurophysiol 1988;59:408-423.
26. Jeftinija S. The role of tetrodotoxin-resistant sodium channels of small primary afferent fibers. Brain Res 1994;639:125-134.
27. Kostyuk PG, Veselovsky NS, Tsyandryenko AY. Ionic currents in the somataic membrane of rat dorsal root ganglion neurons I: Sodium currents. Neuroscience 1981;6:2423-2430.
28. Kuno M, Llinas R. Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurons of the cat. J Physiol (Lond) 1970;210:807-821.
29. + conductance and the threshold for repetitive neuronal firing. Brain Res 1992;597:92-98.
30. + channels. J Neurophysiol 1994;72:349-359.
31. Nordin M, Nystrom B, Wallin U, Hagbarth KE. Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns. Pain 1984;20:231-245.
32. Ochoa J, Torebjork HE. Paresthesiae from ectopic impulse generation in human sensory nerves. Brain 1980;103:835-854.
33. Omana-Zapata I, Khabbaz MA, Hunter JC. Bley KR. QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Res 1997;771:228-237.
34. Oyclcse AA, Rizzo MA, Waxman SG, Kocsis JD. Differential effects of NGF and BDNF on axotomy-induced changes in GABAA-receptor-mediated conductance and sodium currents in cutaneous afferent neurons. J Neurophysiol 1997;78:31-42.
35. Quasthoff S, Grosskreutz J, Schroder JM, Schneider U, Grafe P. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neuroscience 1995;69:955-965.
36. + currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiol Dis 1995a;2:87-96.
37. Rizzo MA, Kocsis JD, Waxman SG. Slow sodium conductances of dorsal root ganglion neurons: Intraneuronal homogeneity and interneuronal heterogeneity. J Neurophys 1995b;72:2796-2816.
38. + channel heterogeneity. Eur Neurol 1996;36:3-12.
39. Rizzo MA. Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. J Neurosci 1997;152:103-106.
40. Roy ML, Narahashi T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J Neurosci 1992;12:2104-2111.
41. Rush AM, Brau ME, Elliott AA, Elliott JR. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. J Physiol 1998;511:771-789.
42. Sangameswaran L, Delgado SG, Fish LM, Koch BD, Jakeman LB, Stewart GR, Sze P, Hunter JC, Eglen RN, Herman RC. J Biol Chem. 1996;271:5953-5956.
43. + channel β1 subunit mRNA in the olfactory system during postnatal development and following denervation. J Neuroscience 1996;16:702-714.
44. + channel mRNA following sensory deprivation of tufted cells in the neonatal rat olfactory bulb. NeuroReport 1997;8:1289-1293.
45. Scadding JW. Development of ongoing activity, mechanosensitivity, and adrenalin sensitivity in severed peripheral nerve axons. Exp Neurol 1981;73:345-364.
46. + channel in rat dorsal root ganglion neurons and their blockade by halothane. Eur J Neurosci 1998;10:2547-2556.
47. + conductance in rat optic nerve axons. Proc Natl Acad Sci 1993;90:6976-6980.
48. + channel expression increases in dorsal root ganglion neurons in the carageenan inflammatory pain model. NeuroRep 1998;9:967-972.
49. Tanaka M, Cummins TR, Ishikawa K, Black JA, Ibata Y, Waxman SG. Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to changes in their input. Proc Natl Acad Sci USA 1999;96:1088-1093.
50. Tate S, Benn S, Hick C, Trezise D, John V, Mannion RJ, Costigan M, Plumpton C, Grose D, Gladwell Z, Kendall G, Dale K, Bountra C, Woolf CJ. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nat Neurosci 1998;1:653-655.
51. Toledo-Aral JJ, Moss BL, He ZJ, Koszowski AG, Whisenand T, Levinson SR, Wolff JJ, Silos-Santiago I, Halegoua S, Mandel G. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci USA 1997;94:1527-1532.
52. Wall PD, Devor M. The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord. Brain Res 1981;209:95-111.
53. Wall PD, Gutnick T. Properties of afferent nerve impulses originating from a neuroma. Nature 1974;248:740-743.
54. Wall PD, Waxman SG, Basbaum AI. Ongoing activity in peripheral nerve: Injury discharge. Exp Neurol 1974;45:576-589.
55. Waxman SG, Brill MH. Conduction through demyelinated plaques in multiple sclerosis: computer simulations of facilitation by short internodes. J Neurol Neurosurg Psychiat 1978;41:408-417.
56. Waxman SG, Kocsis JK, Black JA. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophys 1994;72:466-471.
57. Weskamp G, Otten U. An enzyme-linked immunoassay for nerve growth factor (NGF): A tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues. J Neurochem 1987;48:1779-1786.
58. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winters J. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 1994;62:327-331.
59. Zhang JM, Donnelly DF, Song XJ, LaMotte RH. Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. J Neurophysiol 1997;78:2790-2794.
60. Zur KB, Oh Y, Waxman SG, Black JA. Differential up-regulation of sodium channel α- and β-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF. Mol Brain Res 1995;30:97-103.