Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis

Acta Neuropathologica

Volumn 97, Issue 2, 1999, Pages 119-126

  Schluesener, Hermann J ^a   Seid, Karin ^a   Meyermann, Richard ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Corticosteroids; Cytokine; Inflammation; Leukocyte; Nervous system

Indexed keywords

AUTOANTIGEN; CELL PROTEIN; CYTOKINE; DEXAMETHASONE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; IMMUNOTHERAPY; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MICROGLIA; MONOCYTE; NEURITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RELAPSE; TIME; UVEITIS;

EID: 0033048511     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050964     Document Type: Article

References (41)

1. Akiyama H, Ikeda K, Katoh M. McGeer EG, McGeer PL (1994) Expression of MRP14, 27E10, interferon-a and leukocyte common antigen by reactive microglia in postmortem human brain tissue. J Neuroimmunol 50: 195-201
2. Auphan N, DiDonato JA, Rosette C. Helmgren A, Karin M (1995) Immunosuppression by glucosteroids: inhibition by NF-kB activity through induction of IkB synthesis. Science 270: 286-290
3. Bitar DM, Whitacre CC (1988) Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell Immunol 112: 364-370
4. Bolton C, Flower RJ (1989) The effects of the anti-glucocorticoid RU 38486 on steroid-mediated suppression of experimental allergic encephalomyelitis (EAE) in the Lewis rat. Life Sci 45: 97-104
5. Bosselier KD, Schmitz ML, Berghe WV, Plaisance S, Fiers W, Haegeman G (1997) Glucocorticoid-niediated repression of nuclear factor-kB-dependent transcription involves direct interference with transactivation. Proc Natl Acad Sci USA 94: 13504-13509
6. Brandt A, Giessler J, Schmidt K, Hirschelmann R (1993) Megadose glucocorticoid therapy: investigations in rat anaphylactic shock and experimental allergic encephalomyelitis. Agents Actions 38: C108-111
7. Brück W, Porada P, Poser S, Riekmann P, Hanefeld F, Kretzschmar HA, Lassmann H (1995) Monocyte/macrophage differentiation in early multiple sclerosis lesion. Ann Neurol 38: 788-796
8. Colton CA, Chernyshev ON (1996) Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone. Neurochem Int 29: 43-53
9. Critchfield JM, Zuniga-Pflucker JC, Lenardo MJ (1995) Parameters controlling the programmed death of mature mouse T lymphocytes in high dose suppression. Cell Immunol 160: 71-78
10. Desai S, Barton R (1989) Pharmacological comparison of active and passive experimental allergic encephalomyelitis in the rat. Agents Actions 27: 351-355
11. Fano G, Biocca S, Fulle S, Mariggio MA, Belia S, Calissano P (1995) The S-100: a protein family in search of a function. Prog Neurobiol 46: 71-82
12. Gautam AM (1995) Self and non-self peptides treat autoimmune encephalomyelitis: T cell anergy or competition for major histocompatibility complex class II binding? Eur J Immunol 25: 2059-2063
13. Gold R, Hartung HP, Lassmann H (1997) T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms. Trends Neurosci 20: 399-403
14. Gottschall PE (1996) Beta-amyloid induction of gelatinase B secretion in cultured microglia: inhibition by dexamethasone and indomethacin. Neuroreport 7: 3077-3080
15. Gregorian SK, Clark L, Heber-Katz E, Amento EP, Rostami A (1993) Induction of peripheral tolerance with peptide-specific-anergy in experimental autoimmune neuritis. Cell Immunol 150: 298-310
16. Heizmann CW (1996) Multistep calcium signalling in health and disease. Mol Cells 6: 629-636
17. Kao J, Houck K, Fan Y, et al (1994) Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem 269: 25106-25119
18. Kao J, Fan YG, Haehnel I, Brett J, Greenberg S, Clauss M, Kayton M, Houck K, Kiesel W, Seljelid R, Burnier J, Stern DM (1994) A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response. J Biol Chem 269: 9774-9782
19. Kiefer R, Kreutzberg GW (1991) Effects of dexamethasone on microglial activation in vivo: selective downregulation of major histocompatibility complex class II expression in regenerating facial nucleus. J Neuroimmunol 34: 99-108
20. Kreutzberg GW (1996) Microglia: a sensor of pathological events in the CNS. Trends Neurosci 19: 312-318
21. Levine S, Hoenig EM, Kies MW (1968) Allergic encephalomyelitis: passive transfer prevented by the encephalitogen. Science 161: 1155-1157
22. Mannie MD, Rosser JM, White GA (1995) Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4. Evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition. J Immunol 154: 2642-2654
23. Marvin MR, Libutti SK, Kayton M, et al (1996) A novel tumor-derived mediator that sensitizes cytokine-resistant tumors to tumor necrosis factor. J Surg Res 63: 248-255
24. McCombe PA, Nickson I, Tabi Z, Pender MP (1996) Corticosteroid treatment of experimental autoimmune encephalomyelitis in the Lewis rat results in loss of Vb8.2+ and myelin basic protein-reactive cells from the spinal cord, with increased total T-cell apoptosis but reduced apoptosis of Vb8.2+ cells. J Neuroimmunol 70: 93-101
25. Nguyen KB, McCombe PA, Pender MP (1997) Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous system of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone. J Neuropathol Exp Neurol 56: 58-69
26. Paul C, Bolton C (1995) Inhibition of blood-brain barrier disruption in experimental allergic encephalomyelitis by short-term therapy with dexamethasone or cyclosporine A. Int J Immunopharmacol 17: 497-503
27. Postler E, Lehr A, Schluesener H, Meyermann R (1997) Expression of the S-100 proteins MRP-8 and -14 in ischemic brain lesions. Glia 19: 27-34
28. Racke MK, Critchfield JM, Quigley L, Cannella B, Raine CS, McFarland HF, Leonardo MJ (1996) Intravenous antigen administration as a therapy for autoimmune demyelinating disease. Ann Neurol 39: 46-56
29. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr (1995) Role of transcriptional activation of IkBa in mediating immunosuppression by glucosteroids. Science 270: 283-286
30. Schluesener H (1996) Generalized autoimmunity of the nervous system (GANS) induced by a recombinant protein composed of major pathogenic determinants of MBP. IRBP. and P2 protein: suppression of inflammation by a monoclonal antibody against activated rat T line cells. J Neurosci Res 45: 303-307
31. Schluesener H (1996) Protection against experimental nervous system autoimmune disease by a human immundeficiency virus-1 tat peptide-based polyvalent vaccine. J Neurosci Res 46: 258-262
32. Schluesener H (1997) Protection against generalized autoimmunity of the nervous system (GANS), a novel animal model with combined features of EAE, EAN and EAU by a recombinant HIV-1 Tat37-72 peptide-based multiple T cell epitope vaccine. FEMS Immunol Med Microbiol 17: 170-186
33. Schluesener H, Seid K, Meyermann R (1997) Localization of endothelial-monocyte-activating polypeptide II (EMAP II). a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis and uveilis: expression by monocytes and activated microglial cells. Glia 20: 365-372
34. Schluesener H, Seid K, Meyermann R (1998) Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis and uveitis: expression by activated macrophages and microglial cells. Glia (in press)
35. Tanaka J, Fujita H, Matsuda S, Toku K, Sakanaka M, Maeda N (1997) Glucocorticoid-and mineralcorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Glia 20: 23-37
36. Tas MP, Murray JC (1996) Endothelial-monocyte-activating polypeptide II. Int J Biochem Cell Biol 28: 837-841
37. Utans U, Arceci RJ, Yamashita Y, Russel ME (1995) Cloning and characterization of allograft inflammatory factor-1 : a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J Clin Invest 95: 2954-2962
38. Utans U, Quist WC, McManus BM, Wilson JE, Arceci RJ, Wallace AF, Russel ME (1996) Allograft inflammatory factor-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation 61: 1387-1392
39. Weishaupt A, Gold R, Gaupp S, Giegerich G, Hartung HP, Toyka KV (1997) Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Proc Natl Acad Sci USA 94: 1338-1343
40. Wildner G, Thurau SR (1995) Orally induced bystander suppression in experimental autoimmune uveoretinitis occurs only in the periphery and not in the eye. Eur J Immunol 25: 1292-1297
41. Zettl UK, Gold R, Toyka KV, Hartung HP (1995) Intravenous glucosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat. J Neuropathol Exp Neurol 54: 540-547