Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 506-516

  Bostik, P ^a   Mayne, A E ^a   Villinger, F ^a   Greenberg, K P ^a   Powell, J D ^a   Ansari, A A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD86 ANTIGEN; CYCLOSPORIN A; HYDROXYUREA; RAPAMYCIN; TETANUS TOXOID;

ANIMAL EXPERIMENT; ARTICLE; CERCOCEBUS; CLONAL ANERGY; CONTROLLED STUDY; HUMAN; IMMUNIZATION; IMMUNOSTIMULATION; LENTIVIRINAE; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; VIRUS LOAD;

EID: 0035160940     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.506     Document Type: Article

References (85)

1. Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys)
2. Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques
3. Spectrum of disease in macaque monkeys chronically infected with SIV/SMM
4. Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates
5. Immune activation in lentiviral infection: From Charybdis to scylla?
6. Detection of occult simian immunodeficiency virus SIVsmm infection in asymptomatic seronegative nonhuman primates and evidence for variation in SIV gag sequence between in vivo- and in vitro-propagated virus
7. Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells
8. Comparative sequence analysis of cytokine genes from human and nonhuman primates
9. Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques
10. + T cells derived from non-human primates
11. TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates
12. Studies of CD40L expression by lymphoid cells from experimentally and naturally SIV-infected nonhuman primate species
13. + T lymphocytes and disease progression in simian immunndeficiency virus-infected nonhuman primates
14. Quantitation of antigen-specific immune responses in human immunodeficiency virus (HIV)-infected individuals by limiting dilution analysis
15. HIV infection of monocytes inhibits the T-lymphocyte proliferative response to recall antigens, via production of eicosanoids
16. Impaired immunity in AIDS. The mechanisms responsible and their potential reversal by antiviral therapy
17. Impairment of in vitro immune responses occurs within 3 months after HIV-1 seroconversion
18. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Syrup
19. Tolerance, danger, and the extended family
20. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
21. Models of T cell anergy: Is there a common molecular mechanism?
22. T cell clonal anergy
23. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
24. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
25. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
26. + T cells
27. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
28. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: Both nuclear and cytoplasmic RNAs are regulated with complex kinetics
29. Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells
30. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
31. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells
32. CD56 identifies monocytes and not natural killer cells in rhesus macaques
33. Development of an animal model for autotransfusion therapy: In vitro characterization and analysis of anti-CD3/CD28 expanded cells
34. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
35. + T cell proliferation and production of IFN-γ in response to p24 antigen in HIV-infected individuals: Potential contribution of anergy to HIV-specific unresponsiveness
36. + T cells of human immunodeficiency virus-infected patients after 9 months of highly active antiretroviral therapy
37. HIV-mediated defects in immune regulation
38. HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes
39. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB 1 in interleukin-2 production and immunotherapy
40. Direct evidence that ERK regulates the production/secretion of interleukin-2 in PHA/PMA-stimulated T lymphocytes
41. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells
42. Molecular mechanisms of T lymphocyte activation: Convergence of T cell antigen receptor and 1L-1 receptor-induced signaling at the level of IL-2 gene transcription
43. Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes
44. Concurrent strong tyrosine phosphorylation of a 42,000 MW ERK and a 100,000 MW protein is associated with IL-2 production in human Jurkat T cells
45. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rapl
46. + T cells
47. + T cells
48. 2-terminal kinase and mitogen-activated protein kinase signaling pathways
49. The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells
50. Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease
51. HAART in HIV-infected patients: Restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia
52. Evaluation of T-cell response to CD3 plus CD28 monoclonal antibodies in HIV-1 infected subjects treated with highly active antiretroviral therapy
53. + T cell homeostasis and function in advanced HIV disease
54. Restored humoral immune response to influenza vaccination in HIV-infected adults treated with highly active antiretroviral therapy
55. Dynamics of viral load rebound and immunological changes after stopping effective antiretroviral therapy
56. The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapy
57. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
58. Induction of anergy in resting human T lymphocytes by immobilized anti-CD3 antibodies
59. Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation
60. Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein
61. Cutting edge: Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
62. T-cell co-stimulation through B7RP-1 and ICOS
63. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
64. LICOS, a primordial costimulatory ligand?
65. Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
66. Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes
67. Degree of ERK activation influences both positive and negative thymocyte selection
68. Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo
69. A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis
70. CD69-triggered ERK activation and functions are negatively regulated by CD94/NKG2-A inhibitory receptor
71. CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-ζζ-associated protein-70 signaling pathways in Jurkat T lymphocytes
72. Calcium-induced ERK activation in human T lymphocytes
73. rasRaf-1/MEK-1/ERK-2-independent pathway in stimulation of IL-2 gene transcription in human primary T lymphocytes
74. ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes
75. ras effector pathways regulate nuclear factor of activated T cells
76. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A
77. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy
78. Extracellular signal-regulated kinases in T cells: Anti-CD3 and 4 β-phorbol 12-myristare 13-acetate-induced phosphorylation and activation
79. + T lymphocytes
80. Ligands of CD4 inhibit the association of phospholipase Cγ1 with phosphoinositide 3 kinase in T cells: Regulation of this association by the phosphoinositide 3 kinase activity
81. Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection
82. A cell culture model for T lymphocyte clonal anergy
83. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
84. Evidence for repression of IL-2 gene activation in allergic T cells
85. Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells