A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis

Blood

Volumn 93, Issue 8, 1999, Pages 2454-2462

  Missé, Dorothée ^b   Cerutti, Martine ^b   Noraz, Nelly ^b   Jourdan, Patrick ^b   Favero, Jean ^b   Devauchelle, Gérard ^b   Yssel, Hans ^b   Taylor, Naomi ^b   Veas, Francisco ^a  

^a CNRS   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

ARTICLE; CELL INTERACTION; CONFORMATIONAL TRANSITION; ENDOSOME; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTERNALIZATION; LIGAND BINDING; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0033561091     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.8.2454.408k35_2454_2462     Document Type: Article

References (49)

1. Baggiolini M, Dewald B, Moser B: Human chemokines: An update. Annu Rev Immunol 15:675, 1997
2. Feng Y, Broder CC, Kennedy PE, Berger EA: HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872, 1996
3. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxlon WA: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667, 1996
4. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661, 1996
5. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA: CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955, 1996
6. Deng HK, Unutmaz D, KewalRamani VN, Littman DR: Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296, 1997
7. Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW: The CC chemokine 1-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. J Biol Chem 273:386, 1998
8. Berger EA, Doms RW, Fenyo EM, Korber BT, Littman DR, Moore JP, Sattentau QJ, Schuitemaker H, Sodroski J, Weiss RA: A new classification for HIV-1 [letter]. Nature 391:240, 1998
9. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 α, and MIP-1 β as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811, 1995
10. Amara A, Legall S, Schwartz O, Salamero J, Montes M, Loetscher P, Baggiolini M, Virelizier JL, Arenzana-Seisdedos F: HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med 186:139, 1997
11. Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, Rosenkilde MM, Schwartz TW, Holmes W, Dallas W, Luther MA, Wells TN, Hoxie JA, Marsh M: Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol 139:651, 1997
12. Föster R, Kremmer E, Schubel A, Breitfeld D, Kleinschmidt A, Nerl C, Bernhardt G, Lipp M: Intracellular and surface expression of the HIV-1-coreceptor CXCR4/fusin on various leukocyte subsets: Rapid intemalization and recycling upon activation. J Immunol 160:1522, 1998
13. Lapham CK, Ouyang J, Chandrasekhar B, Nguyen NY, Dimitrov DS, Golding H: Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 274:602, 1996
14. Ugolini S, Moulard M, Mondor I, Barois N, Demandolx D, Hoxie J, Brelot A, Alizon M, Davoust J, Sattentau QJ: HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4. J Immunol 159:3000, 1997
15. Sattentau QJ, Moore JP: Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. J Exp Med 174:407, 1991
16. Sattentau QJ, Moore JP, Vignaux F, Traincard F, Poignard P: Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding. J Virol 67:7383, 1993
17. Wu L, Gerard NP, Wyatt R, Choe H, Parolin C, Ruffing N, Borsetti A, Cardoso AA, Desjardin E, Newman W, Gerard C, Sodroski J: CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384:179, 1996
18. Trkola A, Dragic T, Arthos J, Binley JM, Olson WC, Allaway GP, Cheng-Mayer C, Robinson J, Maddon PJ, Moore JP: CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 384:184, 1996
19. Wyatt R, Desjardin E, Olshevsky U, Nixon C, Binley J, Olshevsky V, Sodroski J: Analysis of the interaction of the human immunodeficiency virus type I gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein. J Virol 71:9722, 1997
20. Hoxie JA, Alpers JD, Rackowski JL, Huebner K, Haggarty BS, Cedarbaum AJ, Reed JC: Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. Science 234:1123, 1986
21. Yuille MA, Hugunin M, John P, Peer L, Sacks LV, Poiesz BJ, Tomar RH, Silverstone AE: HIV-1 infection abolishes CD4 biosynthesis but not CD4 mRNA. J AIDS 1:131, 1988
22. Amadori A, De Silvestro G, Zamarchi R, Veronese ML, Mazza MR, Schiavo G, Panozzo M, De Rossi A, Ometto L, Mous J, Barelli A, Borri A, Salmaso L, Chieco-Bianchi L: CD4 epitope masking by gp 120/anti-gp120 antibody complexes. A potential mechanism for CD4+ cell function down-regulation in AIDS patients. J Immunol 148:2709, 1992
23. Cefai D, Ferrer M, Serpente N, Idziorek T, Dautry-Varsat A, Debre P, Bismuth G: Intemalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p561ck together with impairment of T cell activation. J Immunol 149:285, 1992
24. Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF: HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. J Immunol 151:2928, 1993
25. Rowell JF, Stanhope PE, Siliciano RF: Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class IIMHC. J Immunol 155:473, 1995
26. Gupta S, Vayuvegula B: Human immunodeficiency virus-associated changes in signal transduction. J Clin Immunol 7:486, 1987
27. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM: Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335: 445, 1988
28. Pelchen-Matthews A, Armes JE, Marsh M: Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J 8:3641, 1989
29. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, McKnight A, Thomas JF, Stoebenau-Haggarty B, Choe S, Vance PJ, Wells TN, Power CA, Sutterwala SS, Doms RW, Landau NR, Hoxie JA: CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 87:745, 1996
30. Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R: CD4-independent association between HIV-1 gp120 and CXCR4: Functional chemokine receptors are expressed in human neurons. Curr Biol 7:112, 1997
31. Bandres JC, Wang QF, O'Leary J, Baleaux F, Amara A, Hoxie JA, Zolla-Pazner S, Gorny MK: Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation. J Virol 72:2500, 1998
32. Misse D, Cerutti M, Schmidt I, Jansen A, Devauchelle G, Jansen F, Veas F: Dissociation of the CD4 and CXCR4 binding properties of human immunodeficiency virus type 1 gp120 by deletion of the first putative alpha-helical conserved structure. J Virol 72:7280, 1998
33. Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR: Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 186:1793, 1997
34. Popik W, Hesselgesser JE, Pitha PM: Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ ERK signaling pathway. J Virol 72:6406, 1998
35. Spits H, Yssel H, Terhorst C, de Vries JE: Establishment of human T lymphocyte clones highly cytotoxic for an EBV transformed B cell line in serum-free medium: Isolation of clones that differ in phenotype and specificity. J Immunol 128:95, 1982
36. Yssel H, de Vries JE, Koken M, Van Blitterswijk W, Spits H: Serum-free medium for the generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods 72:219, 1984
37. Jourdan P, Abbal C, Noraz N, Hori T, Uchiyama T, Bousquet J, Taylor T, Pène J, Yssel H: Interleukin-4 induces functional cell-surface expression of CXCR4 on human T cells. J Immunol 160:4153, 1998
38. Endres MJPR, Clapham M, Marsh M, Ahuja J, Davis-Turner A, Mcknight A, Thomas JF, Stoebenau-Haggarty, Choe S, Vance PJ, Wells TNC, Power CA, Sutterwala SS, Doms RW, Landau NR, Hoxie JA: CD4-independent infection by HIV-2 is mediated by fusin/CXCR-4. Cell 87:745, 1996
39. Brelot A, Heveker N, Pleskoff O, Sol N, Alizon M: Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity. J Virol 71:4744, 1997
40. Tokiwa G, Dikic I, Lev S, Schlessinger J: Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273:792, 1996
41. Taylor N, Uribe L, Smith S, Jahn T, Kohn DB, Weinberg K: Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene. Blood 87:3103, 1996
42. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547, 1996
43. Bacon KB, Schall TJ: Chemokine-induced lymphocyte migration: Analysis by filter-based bioassays, in Herzenberg LA, Weir DM, Herzenberg LA, Blackwell A (eds): Weir's Handbook of Experimental Immunology (ed 5). Malden, MA, Blackwell Science, 1997, p 71
44. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833, 1996
45. Bleul CC, Wu LJ, Hoxie JA, Springer TA, Mackay CR: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 94:1925, 1997
46. Pang S, Koyanagi Y, Miles S, Wiley C, Vinters HV, Chen IS: High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients. Nature 343:85, 1990
47. Weissman D, Rabin RL, Arthos J, Rubbert A, Dybul M, Swofford R, Venkatesan S, Farber JM, Fauci AS: Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:981, 1997
48. Dayanithi G, Yahi N, Baghdiguian S, Fantini J: Intracellular calcium release induced by human immunodeficiency virus type 1 (HIV-1) surface envelope glycoprotein in human intestinal epithelial cells: A putative mechanism for HIV-1 enteropathy. Cell Calcium 18:9, 1995
49. Iyengar S, Hildreth JE, Schwartz DH: Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells. J Virol 72:5251, 1998