Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes

International Immunology

Volumn 10, Issue 2, 1998, Pages 223-229

  Egerton, Mark ^a   Fitzpatrick, David R ^a   Kelso, Anne ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Granulocyte macrophage colony stimulating factor; IFN ; IL 10; IL 3; IL 4; IL 5; Mitogen activated extracellular signal regulated kinase; Protein kinase; Protein phosphatase; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0031906529     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.2.223     Document Type: Article

References (31)

1. Paul, W. E. and Seder, R. A. 1994. Lymphocyte responses and cytokines. Cell 76:241.
2. Wange R. L. and Samelson, L. E. 1996. Complex complexes: signaling at the TCR. Immunity 5:197.
3. Rao, A. 1995. NF-ATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction. J. Leuk. Biol. 57:536.
4. Woodrow, M., Clipstone, N. A. and Cantrell, D. 1993. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517.
5. Genot, E., Cleverley, S., Henning, S. and Cantrell, D. 1996. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15:3923.
6. Izquierdo-Pastor, M., Reif, K. and Cantrell, D. 1995. The regulation and function of p21ras during T-cell activation and growth. Immunol. Today 16:159.
7. Izquierdo, M., Leevers, S. J., Marshall, C. J. and Cantrell, D. 1993. p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J. Exp. Med. 178:1199.
8. Coso, O. A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J. S. 1995. The small GTP-binding proteins Rad and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
9. Minden, A., Lin, A., Claret, F. X., Abo, A. and Karin, M. 1995. Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147.
10. Egerton, M., Fitzpatrick, D. R., Catling, A. D. and Kelso, A. 1996. Differential activation of T cell cytokine production by the extracellular signal-regulated kinase pathway. Eur. J. Immunol. 26:2279.
11. Whitehurst, C. E. and Geppert, T. D. 1996. MEK1 and extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J. Immunol. 156:1020.
12. Catling, A. D., Schaeffer, H.-J., M. Reuter, C. W., Reddy, G. R. and Weber, M. J. 1995. A proline-rich sequence unique to MEK1 and MEK2 is required for Raf binding and regulates MEK function. Mol. Cell. Biol. 15:5214.
13. Pang, L., Sawada, T., Decker, S. J. and Saltiel, A. R. 1995. Inhibition of MAP kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270:13585.
14. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. and Saltiel, A. R. 1995. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
15. + cells induced by protein immunization. Immunology 83:25.
16. + T cells and induces synthesis of IL-3 and IFN-γ but not IL-4 or IL-6. Int. Immunol. 4:475.
17. Baumgarth, N., Brown, L., Jackson, D. and Kelso, A. 1994. Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma Interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10. J. Virol. 68:7575.
18. Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich G. J. and Silver, J. E. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5.
19. Egerton, M. and Samelson, L. E. 1994. Biochemical characterization of valosin-containing protein, a protein tyrosine kinase substrate in hematopoietic cells. J. Biol. Chem. 269:11435.
20. Mansour, S. J., Matten, W. T., Hermann, A. S., Candia, J. M., Rong, S., Fukasawa, K., Vande Woude, G. and Ahn, N. G. 1995. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966.
21. Alberola-lla, J., Forbush, K. A., Seger, R., Krebs, E. G. and Perlmutter, R. M. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620.
22. Alberola-lla, J., Hogquist, K. A., Swan, K. A., Bevan, M. J. and Perlmutter, R. M. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:9.
23. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. and Saltiel. A. R. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA 92:7686.
24. Fukunaga, R. and Hunter, T. 1997. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1921.
25. Hodge, M. R., Chun, H. J., Rengarajan, J., Alt, A., Lieberson, R. and Glimcher, L. H. 1996. NF-AT-driven interleukin-4 transcription potentiated by NIP45. Science 274:1903.
26. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483.
27. Jenkins, F., Cockerill, P. N., Bohmann, D. and Shannon, M. F. 1995. Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells. J. Immunol. 155:1240.
28. Masuda, E. S., Tokumitsu, H., Tsuboi, A., Shlomai, J., Hung, P., Arai, K.-I. and Arai, N. 1993. The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLEO mediates signals in T cells and is recognized by factors related to AP1 and NF-AT. Mol. Cell. Biol. 13:7399.
29. Rooney, J. W., Hoey, T. and Glimcher, L. H. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2:473.
30. Baeuerle, P. A. and Baltimore, D. 1996. NF-κB: ten years after. Cell 87:13.
31. Xing, J., Ginty, D. D. and Greenberg, M. E. 1996. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Nature 273:959.