Antiapoptotic role of NF-κB in the auto-oxidized dopamine-induced apoptosis of PC12 cells

Journal of Neurochemistry

Volumn 76, Issue 2, 2001, Pages 602-609

  Lee, Heon Jin ^a   Kim, Sun Hee ^a   Kim, Kwang Woon ^a   Um, Jee Hyun ^a   Lee, Hye Won ^a   Chung, Byung Seon ^a   Kang, Chi Dug ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

Apoptosis; Auto oxidized dopamine; Neuro degeneration; Nuclear factor B; Parkinson's disease

Indexed keywords

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOOXIDATION; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELL DEATH; DNA; DNA-BINDING PROTEINS; DOPAMINE; GENES, DOMINANT; I-KAPPA B PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATION-REDUCTION; PARKINSON DISEASE; PC12 CELLS; PHEOCHROMOCYTOMA; RATS; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

ANIMALIA;

EID: 0035145551     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00076.x     Document Type: Article

References (60)

1. Oxygen free radicals and Parkinson's disease
2. A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease
3. Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
4. Activate NF-kappaB or die?
5. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
6. Pathophysiology of Parkinson's disease
7. Oxidative stress and nuclear factor-kappaB activation: A reassessment of the evidence in the light of recent discoveries
8. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
9. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75
10. Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease
11. The role of c-Jan N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
12. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
13. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
14. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydro-xydopamine, dialuric acid, and related cytotoxic agents
15. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
16. Drug treatment of Parkinson's disease. Time for phase II
17. Role of the Inn kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
18. The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra
19. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
20. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
21. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation
22. Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis
23. Reactive oxygen species and the central nervous system
24. Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
25. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B
26. Does oxidative stress participate in nerve cell death in Parkinson's disease?
27. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis
28. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease
29. Activation of NF-kappa B mediates the PMA-induced differentiation of K562 cells
30. Activation of c-jun N-terminal kinase/stress-activated protein kinase and the decreased ratio of Bcl-2 to Bax are associated with the auto-oxidized dopamine-induced apoptosis in PC12 cells
31. Antioxidant action of neuromelanin: The mechanism of inhibitory effect on lipid peroxidation
32. High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells
33. Is NF-kappaB the sensor of oxidative stress?
34. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B
35. Neuromelanin and its possible protective and destructive properties
36. Dissection of TNF receptor 1 effector functions: INK activation is not linked to apoptosis while NF-kappa;B activation prevents cell death
37. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
38. The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis
39. Dopamine induces apoptotic cell death of a catecholaminergic cell line derived from the central nervous system
40. Roles of nuclear factor kappaB in neuronal survival and plasticity
41. Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B
42. Multiple signals converging on NF-kappaB
43. Dopamine-melanin induces apoptosis in PC 12 cells; possible implications for the etiology of Parkinson's disease
44. A radical hypothesis for neurodegeneration
45. Etiology and pathogenesis of Parkinson's disease
46. Distribution of iron in different brain regions and subcellular compartments in Parkinson's disease
47. A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra
48. KappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase
49. Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging
50. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
51. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
52. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
53. Requirement for ceramide-imtiated SAPK/JNK signalling in stress-induced apoptosis
54. TNF-alpha and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
55. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
56. N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity
57. Mechanisms of neurodegenerative disorders: Part 2: Control of cell death
58. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
59. Opposing effects of ERK and INK-p38 MAP kinases on apoptosis
60. Understanding Parkinson's disease