Dopamine-melanin induces apoptosis in PC12 cells: Possible implications for the etiology of Parkinson's disease

Neurochemistry International

Volumn 31, Issue 2, 1997, Pages 207-216

  Offen, Daniel ^a   Ziv, Ilan ^a   Barzilai, Ari ^a   Gorodin, Svetlana ^a   Glater, Elizabeth ^a   Hochman, Ayala ^a   Melamed, Eldad ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DEFEROXAMINE; DNA FRAGMENT; DOPAMINE; FERROUS CHLORIDE; GLUTATHIONE; MELANIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; DNA DEGRADATION; DNA DETERMINATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; DOPAMINE; DRUG SYNERGISM; IRON; MELANINS; NEUROTOXINS; PARKINSON DISEASE; PC12 CELLS; RATS; SOLUBILITY;

ANIMALIA; PRIMATES;

EID: 0030971573     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00150-7     Document Type: Article

References (42)

1. Agid, Y. (1995) Aging, disease and nerve cell death. Bulletin of the Academy of Natural Medicine 179, 1193-1203.
2. Aime, S., Fasano, M., Bergamasco, B., Lopiano, L. and Valente, G. (1994) Evidence for a glycidic-lipidic matrix in human neuromelanin, potentially responsible for the enhanced iron sequestering ability of substantia nigra. Journal of Neurochemistry 62, 369-371.
3. Bindoli, A., Rigobello, M. P. and Deeble, D. J. (1992) Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radical Biology and Medicine 13, 391-405.
4. Bridelli, M. G., DeMattei, M. and Levi, A. C. (1982) Preliminary spectroscopic studies on the neuromelanic pigment of human substantia nigra nucleus. International Journal of Biochemistry 31, 315-321.
5. Das, K. C., Abramson, M. V. and Katzman, R. (1978) Neuronal pigments: spectroscopic characterization of human brain melanin. Journal of Neurochemistry 30, 601-605.
6. Dexter, D. T., Jenner, P., Schapira, A. H. and Marsden, C. D. (1992) Alteration in levels of iron, ferritin, and other trace metals in neurodegenerative disease affecting the basal ganglia. Annals of Neurology 32, S94-S100.
7. D'Amato, R. J., Alexander, G. M., Schwartzman, G. M., Kitt, C. A., Price, D. L. and Snyder, S. H. (1987) Chloroquine protection of MPTP treated monkeys implicates neuromelanin in MPTP-induced neurotoxicity. Nature 327, 324-325.
8. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Journal of Cell Biology 119, 493-512.
9. Graham, D. G. (1978) Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Molecular Pharmacology 14, 633-643.
10. Graham, D. G. (1984) Catecholamines toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease. Neurotoxicology 5, 83-95.
11. Hastings, T. G. and Zigmond, M. J. (1994) Identification of catechol-protein conjugation in neostriatal slices incubated with 3H dopamine: impact of ascorbic acid and glutathione. Journal of Neurochemistry 63, 1126-1132.
12. Hirsch, E., Graybiel, A. M. and Agid, Y. A. (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334, 345-348.
13. Hirsch, E. (1992) Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease? Annals of Neurology 32(Suppl), S88-S93.
14. Jellinger, P., Kienzl, E., Rumpe, G., Stachelberger, D., Benshachar, D. and Youdim, M. B. H. (1992) Iron-melanin complex in substantia nigra: cause of Parkinson's disease. Journal of Neurochemistry 59, 1168-1171.
15. Jenner, P., Dexter, D. T., Sian, J., Schapira, A. H. V. and Marsden, C. D. (1992) Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. Annals of Neurology 32(Suppl.), S82-S87.
16. Johnson, G. (1971) Quantitation of fluorescence of biogenic monoamines. Progress in Histochemistry & Cytochemistry 2, 299-344.
17. Kastner, A., Hirsch, E. C., Lejeune, O., Javoy-Agid, F., Rascol, O. and Agid, Y. (1992) Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? Journal of Neurochemistry 59, 1080-1089.
18. Kopin, I. J. (1985) Catecholamine metabolism: basic aspects and clinical significance. Pharmacology Review 37, 333-386.
19. Kukielka, E., Puntarulo, S. and Cederbaum, A. I. (1989) Interaction of ferric complexes with rat liver nuclei to catalyze NADH- and NADPH-dependent production of oxygen radicals. Archives of Biochemistry & Biophysics 273, 319-330.
20. Marsden, C. D. (1989) Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. Journal of Neurochemistry 52, 381-389.
21. Marsden, C. D. (1983) Neuromelanin and Parkinson's disease. Journal of Neural Transmission 19, 121-141.
22. 2 generation during neuromelanin synthesis. The action of manganese. Acta Medica Portugal 6, 547-554.
23. Mann, D. M. and Yates, P. O. (1983) Possible role of neuromelanin in the pathogenesis of Parkinson's disease. Mechanisms of Ageing & Development 321, 193-203.
24. Melamed, E., Soffer, D., Rosental, J., Pikarsky, E. and Roches, A. (1987) Effect of intrastriatal and intranigral administration of synthetic neuromelanin on the dopaminergic neurotoxicity of MPTP in rodents. Neuroscience Letters 83, 41-46.
25. Michel, P. and Hefti, F. (1990) Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. Journal of Neuroscientific Research 26, 428-435.
26. Offen, D., Ziv, I., Gordin, S., Malik, Z., Barzilai, A. and Melamed, E. (1995) Dopamine-induced programmed cell death in mouse thymocytes. Biochimica et Biophysica Acta 1268, 171-177.
27. Offen, D., Strenin, H., Ziv, I., Melamed, E. and Hochman, A. (1996) Prevention of dopamine-induced cell death by thiol antioxidants: possible implication for treatment of Parkinson's disease. Experimental Neurology 141, 32-39.
28. Offen, D., Ziv, I., Panet, H., Wasserman, L., Stein, R., Melamed, E. and Barzilai A. (1997) Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2. Molecular and Cellular Neurobiology (in press).
29. Porebska-Budny, M., Sakina, N. L., Sepien, K. B., Dontsov, A. E. and Wilczok, T. (1992) Antioxidative activity of synthetic melanins. Cardiolipid liposome model. Biochimica et Biophysica Acta 1116, 11-16.
30. Pilas, B., Sana, T., Kalyanarman, B. and Schwartz, H. M. (1988) The effect of melanin on Iron associated decomposition of hydrogen peroxide. Free Radical Biology & Medicine 4, 285-293.
31. Schumer, M., Colombel, M., Sawczuk, I. S., Gobe, G., Connor, J., O'Toole, K. M., Olsson, C. A., Wise, G. J. and Buttyan, R. (1992) Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. American Journal of Pathology 140, 831-838.
32. Swartz, H. M., Sama, T. and Zecca, L. (1992) Modulation by neuromelanin of the availability and reactivity of metal ions. Annals of Neurology 32, S69-S75.
33. Spina, M. B. and Cohen, G. (1989) Dopamine turnover and glutathione oxidation: implication for Parkinson's disease. Proceedings of the National Academy of Science, U.S.A. 86, 1398-1400.
34. Swan, G. A. (1963) Chemical structure of melanine. Annals of the NY Academy of Science 100, 1005.
35. Sofic, E. W., Paulus, K., Jellinger, P., Riederer, P. and Youdim, M. B. H. (1991) Selective increase of iron in substantia nigra zona compacta in Parkinsonian brain. Journal of Neurochemistry 56, 978-982.
36. Takashima, A. and Koike, T. (1985) Relation between dopamine content and its secretion in PC12 cells as a function of cell growth. Biochimica et Biophysica Acta 847, 101-107.
37. Youdim, M. B. H., Ben-Shachar, D. and Riederer, P. (1994) The enigma of neuromelanin in Parkinson's disease substantia nigra. Journal of Neural Transmission 43(Suppl), 113-132.
38. Youdim, M. B. H., Ben-Shachar, D. and Riederer, P. (1993) The possible role of iron in the etiopathology of Parkinson's disease. Movement Disorders 8, 1-12.
39. Youdim, M. B. H., Ben-Shachar, D. and Riederer, P. (1989) Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neuro-degeneration. Acta Neurologica Scandinavica 126, 47-54.
40. Zareba, M., Bober, A., Korytowski, W., Zecca, L. and Sarna, T. (1995) The effect of synthetic neuromelanin on yield of free hydroxyl radicals generated in model system. Biochimica et Biophysica Acta 1271, 343-348.
41. Zilkha-Falb, R., Ziv, I., Nardi, N., Offen, D., Melamed E. and Barzilai A. (1997) Monoamine-induced apoptotic neuronal cell death. Cellular and Molecular Neurobiology, 7, 110-118.
42. Ziv, I., Melamed, E., Nardi, N., Luria, D., Achiron, A., Offen, D. and Barzilai, A. (1994) Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons - a possible novel pathogenic mechanism in Parkinson's disease. Neuroscience Letters 170, 136-140.