Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 1057-1062

  Pierre, Philippe ^a,c   Shachar, Idit ^a,b   Matza, Didi ^b   Gatti, Evelina ^a   Flavell, Richard A ^a   Mellman, Ira ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

Cathepsin; Dendritic cell; DM; H2 M; Invariant chain

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; HLA DM ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SPLEEN CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CELLS, CULTURED; CYTOSOL; DENDRITIC CELLS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HALF-LIFE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HYDROLYSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRECIPITATION; PROTEIN FOLDING; RNA, MESSENGER; SPLEEN;

EID: 0034689059     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.1057     Document Type: Article

References (28)

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2. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
3. Invariant chain structure and MHC class II function
4. HLA-DM: An in vivo facilitator of MHC class II peptide loading
5. How HLA-DM edits the MHC class II peptide repertoire: Survival of the fittest?
6. Negative regulation by HLA-DO of MHC class II restricted antigen processing
7. Requirement for invariant chain in B cell maturation and function
8. Invariant chain influences the immunological recognition of MHC class II molecules
9. The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invadant chain
10. Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L
11. Endosomal proteolysis and MHC class II function
12. Endosomal proteases and antigen processing
13. Potent effect of low levels of MHC class II-associated invariant chain on CD4+ T cell development
14. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41
15. BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge
16. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules
17. Developmental regulation of MHC class II transport in mouse dendritic cells
18. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
19. The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif
20. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
21. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
22. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cell
23. Viral strategies of immune evasion
24. Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA
25. Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments
26. Immunological significances of invariant chain from the aspect of its structural homology with the cystatin superfamily
27. The phenotype of H2-M-deficient mice is dependent on the MHC class II molecules expressed
28. Invariant chain-independent function of H2-M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo