High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 2, 2001, Pages 439-446

  Perez Victoria J M ^a   Perez Victoria F J ^a   Conseil, G ^a   Maitrejean, M ^a   Comte, G ^a   Barron, D ^a   Di Pietro, A ^a   Castanys, S ^a   Gamarro, F ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

8 (3,3 DIMETHYLALLYL)DEHYDROSILYBIN; ALLYL COMPOUND; CARRIER PROTEIN; DAUNORUBICIN; DEHYDROSILYBIN; FLAVANONE DERIVATIVE; FLAVONOL DERIVATIVE; GALANGIN; GLYCOPROTEIN P; LIGNAN DERIVATIVE; NUCLEOTIDE; P GLYCOPROTEIN LIKE TRANSPORTER; SILIBININ; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMOSENSITIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; LEISHMANIA TROPICA; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN DOMAIN;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; LEISHMANIA TROPICA; NUCLEOTIDES; OXIDATION-REDUCTION; P-GLYCOPROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN ISOPRENYLATION; PROTEINS; SILYMARIN;

EID: 0035139550     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.2.439-446.2001     Document Type: Article

References (46)

1. Biochemical, cellular and pharmacological aspects of the multidrug transporter
2. 13C nuclear magnetic resonance analysis of two prenyl flavonols from Platanus acerifolia buds
3. Syntheses of 8-C-(1,1-dimethylallyl) flavones and 3-methyl flavonols
4. Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line
5. Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enrietti
6. Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol
7. Flavonoids: A new class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein
8. Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells: Activation of P-glycoprotein as a possible mechanism
9. Binding of steroid modulators to recombinant cytosolic domain from mouse P-glycoprotein in close proximity to the ATP site
10. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
11. P-glycoprotein-mediated resistance to chemoterapy in cancer cells: Using recombinant cytosolic domains to establish structure-function relationship
12. Structural mapping of catalytic site with respect to alpha-subunit and noncatalytic site in yeast mitochondrial F1-ATPase using fluorescence resonance energy transfer
13. The biochemistry of P-glycoprotein-mediated multidrug resistance
14. In vitro and in vivo resistance of Leishmania infantum to meglumine antimoniate: A study of 37 strains collected from patients with visceral leishmaniasis
15. Flavonoid-related modulators of multidrug resistance: Synthesis, pharmacological activity, and structure-activity relationships
16. Pharmacology of drugs that alter multidrug resistance in cancer
17. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene
18. Parasitology: The dawn of a new millennium
19. High efficiency plating method for Leishmania promastigotes in semi-defined or completely-defined medium
20. Detection and characterization of Leishmania species and strains from mammals and vectors by hybridization and restriction endonuclease digestion of kinetoplast DNA
21. Effect of the microtubule stabilising agent taxol on leishmanial protozoan parasites in vitro
22. Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite
23. Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimented visceral leishmaniasis
24. Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani
25. A review of plants used in the treatment of liver diseases: Part 1
26. The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein
27. Leishmaniasis: A re-emerging zoonosis
28. The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer
29. +-ATPase by flavonoids: A structure-activity study
30. ABC transporters in Leishmania and their role in drug resistance
31. The structure of silybin (Silybum substance E6), the first flavanolignan
32. Milk tistle: Silibum marianum
33. Correlation between the affinity of flavonoids binding to cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin
34. New natural sesquiterpenes as modulators of daunomicyn resistance in a multidrug-resistant Leishmania tropica line
35. Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein
36. Anti-proliferative effect of silybin on gynaecological malignacies: Synergism with cisplatin and doxorubicin
37. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast cancer cell line: P-glycoprotein as a possible target
38. Effect of quercetin on Hoechst 33342 transport by purified anti reconstituted P-glycoprotein
39. Positivily cooperative sites for drug transport by P-glycoprotein with disting drug specificities
40. Crystal structure of the Src family tyrosine kinase Hck
41. Silymarin as a potential hypocholesteroalemic drug
42. Current epidemic of visceral leishmaniasis in India
43. Multidrug resistance and P-glycoproteines in parasitic protozoa
44. Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites
45. Amplification of a gene related to the mammalian mdr genes in drug resistance Plasmodium falciparum
46. Silybinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention