Characterization of human killer cell reactivity against porcine target cells: Differential modulation by cytokines

Xenotransplantation

Volumn 8, Issue 1, 2001, Pages 62-74

  Horvath Arcidiacono, Judith A ^a   Bloom, Eda T ^a,b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cytokine; Cytotoxicity; Interleukin; Natural killer cells; T cells

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 8;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; GRAFT REJECTION; IMMUNOMODULATION; IMMUNOPHENOTYPING; LYMPHOCYTE SUBPOPULATION; MONONUCLEAR CELL; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SWINE; XENOGRAFT;

ANIMALS; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; HUMANS; KILLER CELLS, NATURAL; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0035130333     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2001.00078.x     Document Type: Article

References (61)

1. Xenogeneic transplantation
2. A perspective on xenograft rejection and accommodation
3. Early events in cell-mediated recognition of vascularized xenografts: Cooperative interactions between selected lymphocyte subsets and natural antibodies
4. Delayed xenograft rejection
5. Oligosaccharides and discordant xenotransplantation
6. Galα (1,3) Gal, the major xenoantigen (s) recognised in pigs by human natural antibodies
7. The future promises of xenotransplantation
8. The problem of anti-pig antibodies in pig-to-primate xenografting: Current and novel methods of depletion and/or suppression of production of anti-pig antibodies
9. Accommodation of xenografts: Expression of 'protective genes' in endothelial and smooth muscle cells
10. Xenotransplantation: Problems and prospects
11. Accommodation
12. Natural killer cell- and macrophage-mediated rejection concordant xenografts in the absence of T and B cell responses
13. Importance of natural killer cells in the rejection of hamster skin xenografts
14. Xenospecific cytotoxic T lymphocytes
15. Recent advances in the immunology of xenotransplantation
16. Current status of xenotransplantation
17. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells
18. Human anti-pig cell-mediated cytotoxicity in vitro involves non-T as well as T cell components
19. Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells
20. + T-cells in rejection of porcine islet cell xenografts
21. Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period
22. + natural killer cells producing interferon-γ in xenospecific cytotoxic T lymphocyte differentiation
23. HLA-E and HLA-G expression on porcine endothelial cells inhibit xenoreactive human NK cells through CD94/ NKG2-dependent and -independent pathways
24. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection
25. + macrophage and not a T lymphocyte
26. Cellular rejection in discordant xenografts when hyperacute rejection is prevented: Analysis using adoptive and passive transfer
27. Direct cell contact is required to induce expression of e-selectin and IL-8 secretion in pig endothelial cells by human natural killer cells
28. Interactions between T lymphocytes and endothelial cells in allograft rejection
29. Endothelial cell activation and thromboregulation during xenograft rejection
30. Xenotransplantation: Endothelial cell activation and beyond
31. Complement-endothelial cell interactions: Pathophysiological implications
32. Characterization of the human antiporcine immune response
33. Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells
34. Target cell-induced apoptosis of interleukin-2-activated human natural killer cells: Roles of cell surface molecules and intracellular events
35. + cells cultured in stroma-free versus porcine microvascular endothelial cell cultures
36. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells
37. + T lymphocytes in the blood of young pigs identified by specific monoclonal antibodies
38. + T cell family in the pig
39. A triggering structure recognized by G7 monoclonal antibody on porcine lymphocytes and granulocytes
40. Age-related decline in the lethal hit but not the binding stage of cytotoxic T-cell activity in mice
41. Age-related decrement in CTL activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice
42. + cells are required for the apparent restoration of the CTL response
43. Pore-forming protein in individual CTL. The effect of senescence provides a probe for understanding the lytic mechanism
44. Quantification of natural cytotoxicity by human lymphocyte subpopulations isolated by density: Heterogeneity of the effector cells
45. Establishment and characterization of porcine cytolytic cell lines and clones
46. Interleukin-12
47. IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2
48. Simultaneous exposure to interleukin-18 and interleukin-10 in vitro synergistically augments murine spleen natural killer cell activity
49. IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-γ
50. + T cells mediate rejection of porcine xenografts
51. Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells. Cloning, sequencing, and functional expression in human endothelial cells
52. Human T lymphocyte proliferation response to resting porcine endothelial cells results from an HLA-restricted, IL-10-sensitive, indirect presentation pathway but also depends on endothelial-specific costimulatory factors
53. Human T cell responses to human and porcine endothelial cells are highly sensitive to cyclosporine A and FK506 in vitro
54. CD4+ cells play a major role in xenogeneic human anti-pig cytotoxicity through the Fas/Fas ligand lyric pathway
55. Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model
56. Direct activation of porcine endothelial cells by human natural killer cells
57. Effect of interleukin-10 on human anti-porcine xenogeneic cellular response in vitro
58. Porcine and bovine cartilage transplants in cynomolgus monkey. I. A model for chronic xenograft rejection
59. Recent advances in xenotransplantation
60. Inhibition of fibronectin-activated migration of microvascular endothelial cells by interleukin 1β, tumour necrosis factor α and interferon γ
61. Expression profile of active genes in mouse lymph node high endothelial cells