Xenotransplantation: Problems and prospects

Annual Review of Medicine

Volumn 49, Issue , 1998, Pages 301-310

  Bach, Fritz H ^a   Thomas, Lewis ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Endothelial cell activation; Genetic engineering; Transgenic pig

Indexed keywords

CELL ACTIVATION; ENDOTHELIUM CELL; GENETIC ENGINEERING; GRAFT REJECTION; PRIORITY JOURNAL; REVIEW; SWINE; T LYMPHOCYTE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION;

ACUTE DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ENDOTHELIUM, VASCULAR; GENETIC ENGINEERING; GRAFT REJECTION; HUMANS; LYMPHOCYTE ACTIVATION; RESEARCH; SWINE; T-LYMPHOCYTES; TISSUE AND ORGAN PROCUREMENT; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031969966     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.49.1.301     Document Type: Review

References (30)

1. Blakely ML, Van der Werf WJ, Berndt MC, et al. 1994. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58:1059-66
2. Bach FH, Winkler H, Ferran C, et al. 1996. Delayed xenograft rejection. Immunol. Today 17:379-84
3. Candinas D, Bach FH, Hancock WW. 1996. Delayed xenograft rejection in complement-depleted T-cell-deficient rat recipients of guinea pig cardiac grafts. Transplant. Proc. 28:678
4. Bach FH, Robson SC, Ferran C, et al. 1994. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol. Rev. 141:5-30
5. Bach FH, Turman MA, Vercellotti GM, et al. 1991. Accommodation: a working paradigm for progressing toward clinical discordant xenografting. Transplant. Proc. 23:205-07
6. Bach FH, Robson SC, Winkler H, et al. 1995. Barriers to xenotransplantation (see comments). Nature Med. 1:869-73
7. Dalmasso AP, Vercellotti GM, Platt, et al. 1991 Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection. Transplantation 52:530-33
8. Dalmasso AJ, Bach FH. 1996. Expression of human regulators of complement acti-vation on pig endothelial cells. Xeno 4: 55-57
9. White DJG. 1996. hDAF transgenic pig organs: are they concordant for human transplantation? Xeno 4:50-54
10. Sanfilippo F. 1996. Exogenous complement inhibition in xenotransplantation. Xeno 4:46-50
11. Blakely ML, Van der Werf WJ, Dalmasso AP, et al. 1994. Anti-B cell agents: suppression of natural antibodies and prolongation of survival in discordant xenografts. Transplant. Proc. 26:13374-75
12. Sandrin MS, Fodor WL, Mouhtouris E, et al. 1995. Enzymatic remodeling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis (see comments). Nature Med. 1: 1261-67
13. Galili U. 1993. Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans (see comments). Immunol. Today 14:480-82
14. Candinas D, Lesnikoski BA, Hancock WW, et al. 1996. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts. Transplantation 62:1-5
15. 14a.Pearse MJ, Goodman DJ, d'Apice AJF, Chen CG. 1997. Inactivation of NF-KB: a potential strategy to prevent delayed xenograft rejection. Xeno 5:3
16. Grey ST, Tsuchida A, Hau H, et al. 1994. Selective inhibitory effects of the anticoagulant-activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J. Immunol. 153:3664-72
17. Kaczmarek E, Koziak K, Sevigny J, et al. 1996. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271:33116-22
18. Robson SC, Kaczmarek E, Siegel JB, et al. 1997. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J. Exp. Med. 185:153-63
19. Ferran C, Millan MT, Csizmadia V, et al. 1995. Inhibition of NF-kappa B by pyrrolidine dithiocarbamate blocks endothelial cell activation. Biochem. Biophys. Res. Comm. 214:212-23
20. Wrighton CJ, Hofer-Warbinek R, Moll T, et al. 1996. Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp. Med. 183:1013-22
21. Wrighton CJ, McShea A, deMartin R, Tenan C, Bach FH. 1995. Prevention of NF-KB activation in porcine aortic endothelial cells render them sensitive to TNF-α-induced programmed cell death. Int. Congr. Xenotransplantation, 3rd. Boston, MA.
22. Anrather J, Csizmadia V, Brostjan C, et al. 1997. Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B. J. Clin. Invest. 99:763-72
23. 21a. Soares M, Anrather J, Kaczmarek E, et al. 1995. Inhibition of endothelial cell activation by adenovirus mediated overexpression of a transdominant mutant of relA does not sensitize to TNF-α mediated apoptosis. Proc. Congress for Xenotransplantation. Nantes, France.
24. Cooper JT, Stroka DM, Brostjan C, et al. 1996. A20 blocks endothelial cell activation through a NF-kappa B-dependent mechanism. J. Biol. Chem. 271:18068-73
25. Bach FH, Ferran C, Hechenleitner P, et al. 1997. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3:196-204
26. Sachs DH, Sykes M, Greenstein JL, et al. 1995. Tolerance and xenograft, survival. Nature Med. 1:969
27. Auchincloss HJ Jr. 1995. Why is cell-mediated xenograft rejection so strong? Xeno 3:19-23
28. Auchincloss H Jr. 1994. Cell-mediated xenoresponses: strong or weak? Clin. Transplant. 8:155-59
29. Kopp CW, Siegel JB, Hancock WW, et al. 1997. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation 63:749-58
30. Patience C, Takeuchi Y, Weiss RA. 1997. Infection of human cells by an endogenous retrovirus of pigs (see comments). Nature Med. 3:282-86