Human T lymphocyte proliferative response to resting porcine endothelial cells results from an HLA-restricted, IL-10-sensitive, indirect presentation pathway but also depends on endothelial-specific costimulatory factors

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1652-1658

  Vallée, Isabelle ^a,b   Guillaumin, Jean Maurice ^a   Thibault, Gilles ^a   Gruel, Yves ^a   Lebranchu, Yvon ^a   Bardos, Pierre ^a   Watier, Hervé ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT INTERLEUKIN 10;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNE ADHERENCE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL SEPARATION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DQ ANTIGENS; HUMANS; INTERLEUKIN-10; INTERPHASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; PEPTIDES; SWINE; SWINE, MINIATURE;

EID: 0032529622     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Cozzi, E., and D. J. White. 1995. The generation of transgenic pigs as potential organ donors for humans. Nat. Med. 1:964.
2. Parker, W., S. Saadi, S. Lin, Z. Holzknecht, M. Bustos, and J. Platt. 1996. Transplantation of discordant xenografts: a challenge revisited. Immunol. Today 17:373.
3. Bach, F., H. Winkler, C. Ferran, W. Hancock, and S. Robson. 1996. Delayed xenograft rejection. Immunol. Today 17:379.
4. Nowak, R. 1994. Xenotransplants set to resume. Science 266:1148.
5. Fedoseyeva, E. V. 1995. Mechanisms of alloantigen recognition in transplantation. Biochemistry (Moscow) 60:169.
6. Kumagai-Braesch, M., M. Satake, O. Korsgren, A. Andersson, and E. Möller. 1993. Characterization of cellular human anti-porcine xenoreactivity. Clin. Transplant. 7:273.
7. Kirk, A., R. A. Li, M. S. Kinch, K. A. Abernethy, C. Doyle and, R. Bollinger. 1993. The human antiporcine cellular repertoire: in vitro studies of acquired and innate cellular responsiveness. Transplantation 55:924.
8. Dorling, A., R. Binns, and R. Lechler. 1996. Cellular xenoresponses: although vigorous, direct human T cell anti-pig primary xenoresponses are significantly weaker than equivalent alloresponses. Xenotransplantation 3:149.
9. Satake, M., N. Kawagishi, and E. Moller. 1996. Direct activation of human responder T cells by porcine stimulator cells leads to T cell proliferation and cytotoxic T cell development. Xenotransplantation 3:198.
10. Yamada, K., J. D. Seebach, H. DerSimonian, and D. Sachs. 1996. Human anti-pig T-cell mediated cytotoxicity. Xenotransplantation 3:179.
11. Cunningham, A. C., T. J. Butler, and J. A. Kirby. 1994. Demonstration of direct xenorecognition of porcine cells by human cytotoxic T lymphocytes. Immunology 81:268.
12. Pober, J. S., C. G. Orosz, M. L. Rose, and C. O. Savage. 1996. Can graft endothelial cells initiate a host anti-graft immune response? Transplantation 61:343.
13. Vallée, I., H. Watier, G. Thibault, H. Salmon, Y. Gruel, Y. Lebranchu, and P. Bardos. 1995. Evidence of noninvolvement of swine MHC class II in the in vitro proliferative response of human lymphocytes to porcine endothelial cells. Transplantation 59:897.
14. Murray, A. G., M. M. Khodadoust, J. S. Pober, and A. L. M. Bothwell. 1994. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1:57.
15. Rollins, S. A., S. P. Kennedy, A. J. Chodera, E. A. Elliott, G. B. Zavoico, and L. A. Matis. 1994. Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2. Transplantation 57:1709.
16. Bravery, C. A., P. Batten, M. H. Yacoub, and M. L. Rose. 1995. Direct recognition of SLA-and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and releases of interleukin-2. Transplantation 60:1024.
17. Watier, H., I. Vallée, G. Thibault, A. C. Lalmanach, M. Lacord, Y. Gruel, Y. Lebranchu, H. Salmon, and P. Bardos. 1994. Effect of human inflammatory cytokines on porcine endothelial cell MHC molecule expression: unique role for TNF-α in MHC class-II induction. Transplant. Proc. 26:1152.
18. Dorling, A., R. Binns, and R. I. Lechler. 1996. Cellular xenoresponses: observation of significant primary indirect human T cell anti-pig xenoresponses using co-stimulator-deficient or SLA class II-negative porcine stimulators. Xenotransplantation 3:112.
19. Dorling, A., G. Lombardi, R. Binns, and R. I. Lechler. 1996. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur. J. Immunol. 26:1378.
20. Auchincloss, H., and H. Sultan,. 1996. Antigen processing and presentation in transplantation. Curr. Opin. Immunol. 8:681.
21. Czitrom, A. A. 1996. The immune response: the afferent arm. Clin. Orthopaedics 326:1.
22. Sachs, D. H., G. Leight, J. Cone, S. Schwarz, L. Stuart, and S. Rosenberg. 1976. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 22:559.
23. Laude, H., J.-M. Chapsal, J. Gelfi, S. Labiau, and J. Grosclaude 1986. Antigenic structure of transmissible gastroenteritis virus. I. Properties of monoclonal antibodies directed against virion proteins. J. Gen. Virol. 67:119.
24. Freundlich, B., and N. Avdalovic. 1983. Use of gelatin/plasma coated flasks for isolating human peripheral blood monocytes. J Immunol. Methods 62:31.
25. Fermand, J.-P, A. Chevalier, and J.-C. Brouet. 1986. Characterization of a mAb recognizing a monomorphic determinant of the α-chain of class II DQ antigens. Scand. J. Immunol. 24:313.
26. Ivanoska, D., D. C. Sun, and J. K. Lunney. 1991. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics 33:220.
27. Moreno, J., and P. E. Lipsky. 1986. Differential ability of fixed antigen-presenting cells to stimulate nominal antigen-reactive and alloreactive T4 lymphocytes. J. Immunol. 136:3579.
28. Hammerberg, C., and G. G. Schurig. 1986. Characterization of monoclonal antibodies directed against swine leukocytes. Vet. Immunol. Immunopathol. 11:107.
29. Galili, U., F. Anaraki, A. Thall, C. Hillblack, and M. Radic. 1993. One percent of human circulating B-lymphocytes are capable of producing the natural anti-Gal antibody. Blood 82:2485.
30. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
31. Hughes, C., C. Savage, and J. Pober. 1990. Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/ LFA-3 interaction. J. Exp. Med. 171:1453.
32. Rock, K., L. Rothstein, S. Gamble, and C. Fleischacker. 1993. Characterization of antigen-presenting cells that present exogenous antigens in association with class I molecules. J. Immunol. 150:438.
33. Breurvriesendorp, B. S., and P. Ivanyi. 1993. Self-restricted primary human histocompatibility leukocyte antigen (HLA)-specific cytotoxic lymphocytes-T. Int. Immunol. 5:103.
34. Sawyer, G. J., R. Dalchau, and J. W. Fabre. 1993. Indirect T cell allorecognition: a cyclosporine A resistant pathway for T cell help for antibody production to donor MHC antigens. Transplant, Immunol. 1:77.
35. Bromberg, J. S. 1995. IL-10 immunosuppression in transplantation. Curr. Opin. Immunol. 7:639.
36. de Waal Malefyt, R., J. Haanen, H. Spits, M.-G. Roncarolo, A. teVelde, C. Figdor, K. Johnson, R. Kastelein, H. Issel, and J. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J. Exp. Med.
37. Willems, F., A. Marchant, J. P. Delville, C. Gerard, A. Delvaux, T. Velu, M. Deboer and M Goldman. 1994. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur. J. Immunol. 24:1007.
38. Liu, Z., Y. K. Sun, Y. P. Xi, A. Maffei, E. Reed, P. Harris, and N. Suciu-Foca. 1993. Contribution of direct and indirect recognition pathways to T-cell alloreactivity. J. Exp. Med. 177:1643.
39. Liu, Z., E. Reed, P. Harris, and N. Suciu-Foca. 1993. Role of anti-HLA immune response in organ transplant rejection. In Rejection and Tolerance. J.-L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J.P. Revillard, and C. Dupuy, eds. Kluver, Dordrecht, The Netherlands, p. 111.
40. Warrens, A., G. Lombardi, and R. Lechler. 1994. MHC and alloreactivity: presentation and recognition of major and minor histocompatibihty antigens. Transplant. Immunol. 2:103.
41. Karmann, K., C. C. W. Hughes, J. Schechner, W. C. Fanslow, and J. S. Pober. 1995. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc. Natl. Acad. Sci. USA 92:4342.
42. Yellin, M. J., J. Brett, D. Baum, A. Matsushima, M. Szabolcs, D. Stern, and L. Chess. 1995. Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals. J. Exp. Med. 182:1857.
43. Lechler, R. I., and F. Marelli-Berg. 1997. Do endothelial cells fit the paradigm of antigen-presenting cells? Biochem. Soc. Trans. 25:723.
44. Liu, Y., and C. Janeway. 1992. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. USA 89:3845.
45. Wingren, A. G., E. Parra, M. Varga, T. Kalland, H. O. Sjogren, G. Hedlund, and M. Dohlsten. 1995. T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles. Crit. Rev. Immunol. 15:235.