Human cell-mediated rejection of porcine xenografts in an immunodeficient mouse model

Transplantation

Volumn 63, Issue 9, 1997, Pages 1331-1338

  Sawada, Tokihiko ^a   Dellapelle, Patricia A ^a   Seebach, Jörg D ^a   Sachs, David H ^a   Colvin, Robert B ^a   Iacomini, John ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GRAFT REJECTION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

ADOPTIVE TRANSFER; ANIMALS; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GRAFT REJECTION; HUMANS; IMMUNITY, CELLULAR; IMMUNOLOGIC DEFICIENCY SYNDROMES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; SKIN; SKIN TRANSPLANTATION; SWINE; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030958275     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199705150-00022     Document Type: Article

References (61)

1. Auchincloss H Jr. Xenogeneic transplantation: a review. Transplantation 1988; 46: 1.
2. Tumbleson ME. Swine in biomedical research. New York: Plenum Press, 1986.
3. Sachs DH. Transplantation tolerance. Ann Thorac Surg 1993; 56: 1221.
4. Sachs DH. The pig as a potential xenograft donor. Pathol Biol 1994; 42: 217.
5. Sachs DH, Leight G, Cone J, Schwarz S, Stuart L, Rosenberg S. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 1976; 22: 559.
6. Sachs DH. MHC homozygous miniature swine. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as models in biomedical research. Ames, IA: Iowa State University Press, 1992: 3.
7. Platt JL, Lindman BJ, Geller RL, et al. The role of natural antibodies in the activation of xenogenic endothelial cells. Transplantation 1991; 52: 1037.
8. Platt JL, Lindman BJ, Chen H, Spitalnik SL, Bach FH. Endothelial cell antigens recognized by xenoreactive human natural antibodies. Transplantation 1990; 50: 817.
9. Oriol R, Ye Y, Koren E, Cooper DK. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 1993; 56: 1433.
10. Sandrin MS, Vaughan HA, Dabkowski PL, McKenzie IF. Antipig IgM antibodies in human serum react predominantly with Ga(alpha 1-3)Gal epitopes. Proc Natl Acad Sci USA 1993; 90: 11391.
11. Kaufman CL, Gaines BA, Ildstad ST. Xenotransplantation. Annu Rev Immunol 1995; 13: 339.
12. Murray AG, Khodadoust MM, Pober JS, Bothwell AL. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1: 57.
13. Kirk AD, Li RA, Kinch MS, Abernethy KA, Doyle C, Bollinger RR. The human antiporcine cellular repertoire: in vitro studies of acquired and innate cellular responsiveness. Transplantation 1993; 55: 924.
14. Yamada K, Sachs DH, DerSimonian H. The human anti-porcine xenogeneic T-cell response: evidence for allelic specificity of MLR and for both direct and indirect pathways of recognition. J Immunol 1995; 155: 5249.
15. Yamada K, Seebach JD, DerSimonian H, Sachs DH. Human anti-pig T cell mediated cytotoxicity. Xenotransplant 1996; 3: 179.
16. Sadeghi AM, Robbins RC, Smith CR, et al. Cardiac xenotransplantation in primates. J Thorac Cardiovasc Surg 1987; 93: 809.
17. Edwards NM, Rose EA. The use of non-human primates in xenotransplantation research. In: Hardy MA, ed. Xenograft 25. New York: Excerpta Medica, 1989: 79.
18. Tanaka M, Latinne D, Gianello P, et al. Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism. Transplant Proc 1994; 26: 1326.
19. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869.
20. Kirkman RL, Colvin RB, Flye MW, Williams GM, Sachs DH. Transplantation in miniature swine. VII. Evidence for cellular immune mechanisms in hyperacute rejection of renal alografts. Transplantation 1979; 28: 24.
21. Kirkman RL, Flye MW, Williams GM, Colvin RB, Sachs DH. Evidence for cellular immune mechanisms in hyperacute rejection of renal allografts in miniature swine. Transplant Proc 1979; 11: 790.
22. Davis WC, Perryman LE, McGuire TC. Hybridoma technology in agricultural and veterinary research. Totowa, NJ: Rowan and Allanheld, 1984.
23. Pennington LR, Lunney JK, Sachs DH. Transplantation in miniature swine. VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation 1981; 31: 66.
24. Seebach JD, Yamada K, McMorrow I, Sachs DH, DerSimonian H. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells. Xenotransplant 1996; 3: 188.
25. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations. Am J Pathol 1994; 144: 260.
26. Murray AG, Petzelbauer P, Hughes CCW, Costa J, Askenase P, Pober JS. Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc Natl Acad Sci USA 1994; 91: 9146.
27. Mombaerts P, Mizoguchi E, Ljunggren H, et al. Peripheral lymphoid development and function in TCR mutant mice. Int Immunol 1994; 6: 1061.
28. Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301: 527.
29. Bosma MJ, Carroll AM. The scid mouse mutant:definition,characterization and potential uses. Annu Rev Immunol 1991; 9: 323.
30. Tary-Lehmann M, Saxon A, Lehmann PV. The human immune system in hu-PBL-SCID mice. Immunol Today 1995; 16: 529.
31. Alegre M, Peterson LJ, Jeyarajah DR, Weiser M, Bluestone JA, Thistlethwaite JR. Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject allografts. J Immunol 1994; 153: 2738.
32. Kawamura T, Niguma T, Fechner JHJ, et al. Chronic human skin graft rejection in severe combined immunodeficient mice engrafted with human PBL from an HLA-presensitized donor. Transplantation 1992; 53: 659.
33. Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989; 59: 1035.
34. Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990; 248: 1517.
35. Shinkai Y, Rathburn G, Lam K-P, et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992; 68: 855.
36. Bosma GC, Fried M, Custer RP, Carroll A, Gibson DM, Bosma MJ. Evidence for functional lymphocytes in some (leaky) scid mice. J Exp Med 1988; 167: 1016.
37. Carroll AM, Bosma MJ. Detection and characterization of functional T cells in mice with severe combined immune deficiency. Eur J Immunol 1988; 18: 1965.
38. Carroll AM, Hardy RR, Bosma MJ. Occurence of mature B (IgM+,B220+) and T (CDS+) lymphocytes in scid mice. J Immunol 1989; 143: 1087.
39. Fulop GM, Phillips RA. The scid mutation in mice causes a general defect in DNA repair. Nature 1990; 347: 479.
40. Biedermann KA, Sun J, Giaccia AJ, Tosto LM, Brown JM. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci USA 1991; 88: 1394.
41. Hendrickson EA, Qin S, Bump EA, Schatz DG, Oettinger MA, Weaver DT. A link between double-strand break-related repair and DNA recombination: the scid mutation. Proc Natl Acad Sci USA 1991; 88: 4061.
42. Bravery CA, Batten P, Yacoub MH, Rose ML. Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin-2. Transplantation 1995; 60: 1024.
43. Kumagai-Braesch M, Satake M, Korsgren O, Andersson A, Moller E. Characterization of cellular human anti-porcine xenoreactivity. Clin Transpl 1993; 7: 273.
44. Rollins SA, Kennedy SP, Chodera AJ, Elliot EA, Zavoico GB, Matis LA. Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2. Transplantation 1994; 57: 1709.
45. + cells in the cellular rejection of a discordant xenograft. Transplant Proc 1993; 25: 447.
46. Gress RE, Nathenson SG, Lucas PJ. Fine specificity of xenogeneic antigen recognition by human T cells. Transplantation 1989; 48: 93.
47. Gress RE, Katz SI, Lucas PJ. Human CD8+ xenoreactive T cells mediate tissue injury in vivo. Transplantation 1992; 56: 484.
48. Satake M, Korsgren O, Ridderstad A, Karlsson-Parra A, Wallgren A-C, Moller E. Immunological characteristics of islet cell transplantation in humans and rodents. Immunol Rev 1995; 141: 191.
49. Inverardi L, Pardi R. Early events in cell-mediated recognition of vascularized xenografts: cooperative interactions between selected lymphocyte subsets and natural antibodies. Immunol Rev 1994; 141: 71.
50. Galili U. Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans. Immunol Today 1993; 14: 480.
51. Dalmasso AP, Vercellotti GM, Platt JL, Bach FH. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991; 52: 530.
52. Zhao Z, Termignon JL, Cardoso J, et al. Hyperacute xenograft rejection in the swine-to-human donor-recipient combination: in vitro analysis of complement activation. Transplantation 1994; 57: 245.
53. Miyagawa S, Shirakura R, Matsumiya G, et al. Prolonging discordant xenograft survival with anticomplement reagents K76COOH and FUT175. Transplantation 1993; 55: 709.
54. Pruitt SK, Baldwin WM, Barth RN, Sanfilippo F. The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. Transplantation 1993; 56: 1318.
55. Dalmasso AP. The complement system in xenotransplantation. Immunopharmacology 1992; 24: 149.
56. Pruitt SK, Baldwin WM III, Marsh HC Jr, Lin SS, Yeh CG, Bollinger RR. The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 1991; 52: 868.
57. Sachs DH, Winn HJ, Russell PS. The immunologic response to xenografts: recognition of mouse H-2 histocompatibility antigens by the rat. J Immunol 1971; 107: 481.
58. Robson SC, Candinas D, Hancock WW, Wrighton C, Winkler H, Bach FH. Role of endothelial cells in transplantation. Int Arch Allergy Immunol 1995; 106: 305.
59. Hoffmann MW, Wonigeit K, Steinhoff G, Herzbeck H, Flad H-D, Pichlmayr R. Production of cytokines (TNF-alpha, IL-1-beta) and endothelial cell activation in human liver allograft rejection. Transplantation 1993; 55: 329.
60. Leeuwenberg JFM, Van Damme J, Meager T, Jeunhomme TMAA, Buurman WA. Effects of tumor necrosis factor on the interferon-gamma-induced major histocompatibility complex class II antigen expression by human endothelial cells. Eur J Immunol 1988; 18: 1469.
61. + T cells. J Exp Med 1989; 170: 991.