Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis

British Journal of Cancer

Volumn 84, Issue 4, 2001, Pages 504-511

  Soria, J C ^a,b   Morat, L ^b   Commo, F ^a   Dabit, D ^a   Perie, S ^a   Sabatier, L ^b   Fouret, P ^c  

^a HÔPITAL TENON   (France)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Expression; Head and neck; P16; Squamous cell carcinoma; Telomerase

Indexed keywords

CYCLIN D1; KI 67 ANTIGEN; PROTEIN P16; RETINOBLASTOMA PROTEIN; TELOMERASE;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; WART VIRUS;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DNA, NEOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PAPILLOMAVIRIDAE; POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; TELOMERASE;

EID: 0035099834     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1647     Document Type: Article

References (45)

1. Abnormal patterns of D-type cyclin expression and GI regulation in human head and neck cancer
2. Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract
3. Downregulation of 14-13-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes
4. Expression profile of telomerase subunits in human pleural mesothelioma
5. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
6. Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss
7. Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated turnout proliferation
8. Mechanisms of p16INK4a inactivation in non small-cell lung cancers
9. Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies
10. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
11. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
12. Fibroblast growth factor 2 upregulates telomerase activity in neural precursor cells
13. p16(INK4a) and the control of cellular proliferative life span
14. Dysregulated cyclin D, expression early in head and neck tumorigenesis: In vivo evidence for an association with subsequent gene amplification
15. p16MTS1/CDK41 mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx
16. Interactions of the human papillomavirus E7 protein, with cell cycle regulators
17. Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: Potential synergistic effect with altered p53 protein on proliferative activity
18. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
19. Telomerase activation by the E6 gene product of human papillomavirus type 16
20. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
21. Rb and p16INK4a expression in resected non-small cell lung tumors
22. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
23. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes
24. Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues
25. Analyzing data from ordered categories
26. Role of the alternative INK4A proteins in human keratinocyte senescence: Evidence for the specific inactivation of p16INK4a upon immortalization
27. Telomerase activity in oral leukoplakia and head and neck squamous cell carcinoma
28. Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer
29. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma
30. Alterations of the p16 gene in head and neck cancer: Frequency and association with p53, PRAD-1 and HPV
31. pRb and p16 protein alterations in human oral tumorigenesis
32. Frequent inactivation of p16INK4a in oral premalignant lesions
33. The restriction point and control of cell proliferation
34. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
35. High frequency of p16 (CDKN2/MTS-INK4A) inactivation in head and neck squamous cell carcinoma
36. Detection and typing of human papillomavirus in archival cervical cancer specimens by DNA amplification with consensus primers
37. Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non- small cell lung cancer
38. Role of the INK4a locus in tumor suppression and cell mortality
39. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
40. A survey of telomerase activity in human cancer
41. Telomerase components as a diagnostic tool in human oral lesions
42. DNA studies underestimate the major role of CDKN2A inactivation in oral and oropharyngeal squamous cell carcinomas
43. Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma
44. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
45. Senescence of human fibroblasts induced by oncogenic Raf