Alterations of intralesional and lymph node gene expression and cellular composition induced by IL-12 administration during leishmaniasis

Parasite Immunology

Volumn 23, Issue 2, 2001, Pages 71-84

  Schopf, Lisa R ^a,b   Erickson, Jamie ^a   Hayes, Lori ^a   Chung, Charles ^a   Lavigne, Liz ^a   Sypek, Joseph ^a  

^a PFIZER INC   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

IL 12; Inflammation; Leishmania major; Resistance; Susceptibility; Th1 cells; Th2 cells

Indexed keywords

INTERLEUKIN 12; NITRIC OXIDE SYNTHASE; RECOMBINANT INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FOOT PAD; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNE RESPONSE; INFECTION CONTROL; INFLAMMATION; LEISHMANIA; LEISHMANIASIS; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FOOT; HISTOCYTOCHEMISTRY; INTERLEUKIN-12; INTERLEUKINS; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPH NODES; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE; POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; STAINING AND LABELING;

ANIMALIA; LEISHMANIA MAJOR;

EID: 0035079286     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2001.00360.x     Document Type: Article

References (72)

1. Patterns of lymphokine secretion in murine leishmaniasis: Correlation with disease progression or resolution
2. Reciprocal expression of interferonγ or interleukin 4 during the resolution or progression of murine leishmaniasis: Evidence for expansion of distinct helper T cell subsets
3. Reconstitution of Leishmania immunity in severe combined immunodeficiency mice using Th1- and Th2-like cell lines
4. + T cell clones recognizing antigen (s) associated with live parasites
5. The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis
6. Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes
7. Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or excaberation belong to different T helper subsets and respond to distinct parasite antigens
8. Production of natural killer stimulatory factor (IL12) by peripheral blood mononuclear cells
9. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones
10. Identification and purification of natural killer stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
11. Natural killer cell stimulatory factor (IL12) induces TH1-specific immune responses and inhibits the development of IL-4 producing TH cells
12. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
13. Recombinant interleukin 12 cures mice infected with Leishmania major
14. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response
15. Cutaneous leishmaniasis-a case with persistent organisms after treatment in presence of normal immune response
16. Cell contact-mediated macrophage activation for antileishmanial defense. I. Lymphocyte effector mechanism that is contact dependent and noncytotoxic
17. Recognition of protozoan parasite antigens by murine T lymphocytes I. Induction of specific T lymphocyte-dependent proliferative response to Leishmania tropica
18. Identification of an infective stage of Leishmania promastigotes
19. Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species
20. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
21. PCR MIMICS. Competitive DNA fragments for use as internal standards in quantitative PCR
22. + cells correlate with resolution of lesions in murine cutaneous leishmaniasis
23. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection
24. Interleukin-12 in murine leishmaniasis-match, flame or fuel?
25. Immunoregulation of murine leishmaniasis by interleukin-12
26. Endogenous IL-12 is required for control of Th2 cytokine responses capable of excaberating leishmaniasis in normally resistant mice
27. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
28. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon-gamma-independent mechanism
29. IFN-gamma modulates the early development of Th1 and Th2 responses in a model of cutaneous leishmaniasis
30. IL-4 induces a Th2 response in Leishmania major-infected mice
31. Early parasite containment is decisive for resistance to Leishmania major infection
32. The regulation of immunity to Leishmania major
33. + T cells
34. Murine cutaneous leishmaniasis: Resistance correlates with the capacity to generate interferon-γ in response to leishmania antigens in vitro
35. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice
36. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis
37. Infection with Leishmania major induces interleukin-12 production in vivo
38. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
39. Murine dendritic cells internalize Leishmania major promastigotes, produce IL-12p40 and stimulate primary T cell proliferation
40. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: Implications for the initiation of anti-Leishmania immunity
41. The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor β2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12
42. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase
43. Effect of vivo inhibition of nitric oxide production in murine leishmaniasis
44. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
45. Cytokine-induced synthesis of nitrogen oxides in macrophages: A protective host response to Leishmania and other intracellular pathogens
46. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine
47. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
48. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major
49. Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: Implication for the antitumor activity of interleukin 12 and/or interleukin 2
50. IL-2 is necessary for the progression of Leishmaniasis in susceptible murine hosts
51. Interleukin-2 suppresses activated macrophage intracellular killing activity by inducing macrophages to secrete TGF-beta
52. Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major
53. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis
54. Resistance of BALB/c mice to Leishmania major infection is associated with a decrease in the precursor frequency of antigen-specific CD4+ cells secreting interleukin-4
55. In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-
56. Leishmania major: Targeting IL-4 in successful immunomodulation of murine infection
57. Depletion of interleukin-4 in BALB/c mice with established Leishmania major infections increases the efficacy of antimony therapy and promotes Th1-like responses
58. IL-4 deficient BALB/c mice resist infection with Leishmania major
59. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major
60. Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4
61. Susceptibility to Leishmania major infection in interleukin-4-deficient mice
62. Interleukin-12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin-10 is a physiologic antagonist
63. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection
64. An in vitro model for infection with Leishmania major that mimics the immune response in mice
65. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis
66. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection
67. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
68. Endogenous interleukin-12 regulates acquired resistance in experimental visceral leishmaniasis
69. Intracellular antimicrobial activity in the absence of interferon-γ: Effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice
70. Role of interferon-gamma in interleukin 12-induced pathology in mice
71. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses
72. Genetic susceptibility to leishmania: IL-12 responsiveness in TH1 cell development