An in vitro model for infection with Leishmania major that mimics the immune response in mice

Infection and Immunity

Volumn 65, Issue 7, 1997, Pages 2837-2845

  Soares, Milena B P ^a   David, John R ^a   Titus, Richard G ^b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL MODEL; ARTICLE; IMMUNE RESPONSE; INFECTION SENSITIVITY; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030967584     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.7.2837-2845.1997     Document Type: Article

References (63)

1. Ahu-Shakra, M., and Y. Shoenfeid. 1991. Parasitic infection und autoimmunily. Autoimmunity 9:337-344.
2. Afonso, L. C. C., T. M. Scharton, L. Q. Vieiru, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237.
3. Baron, J. L., J. A. Mardi, N. H. Ruddle, G. Hashim, and C. A. Janeway, Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57-68.
4. Barral-Netto, M., A. Barral, C. E. Brownell, Y. A. W. Skeiky, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in leishmanial infection: a parasite escape mechanism. Science 257:545-548.
5. Behin, R., J. Mauel, and B. Sordut. 1979. Leishmania tropica pathogecnicity and in vitro mucrophage function in strains of inbred mice, Exp. Parasitol. 48:81-93.
6. Belosevic, M., D. S. Finbloom, P. H. van der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266-274.
7. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295-1304.
8. Chakkalath, H. R., and R. G. Titus. 1994. Leishmania major-parasitized macrophages augment Th2-type T cell activation. J. Immunol. 153:4378-4387.
9. Chan, J., T. Fujiwara, P. Brennan, M. McNeil, S. J. Turco, J.-C. Sibille, M. Snapper, P. Aisen, and H. R. Bloom. 1989. Microbial glycoplipids: possible virulence factors that scavenge oxygen radicals. Proc. Natl. Acad. Sci. USA 86:2453-2457.
10. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182-1187.
11. Cillari, E., M. Dieli, E. Maltese, S. Milano, A. Salerno, and F. Y. Liew, 1989. Enhancement of macrophage IL-1 production by Leishmania major infection in vitro and its inhibition by IFN-γ. J. Immiinol. 143:2001-2005.
12. + T-cell subsets in vivo. Immunol. Rev. 123:189-207.
13. Corradin, S. B., N. Fasel, Y. Hudiimiller-Rouiller, A. Ransijn, J. Smith, and J. Mauel. 1993. Induction of maconphage nitric oxide production by interferon-γ and tumor necrosis factor-α is enhanced by interleukin-10. Eur. J. Immunol. 23:2045-2048.
14. Descoteaux, A., S. J. Turco, D. L. Sacks, and G. Matlashewski. 1991. Leishmania donovni lipophospho-glycan selectively inhibits signal transduction in maerophages. J. Immunol. 146:2747-2753.
15. Ding, A., C. F. Nathan, J. Graycar, R. Derynck, D. J. Stuehr, and S. Srimal. 1990. Macrophage deactivating factor and transforming growth factors-β1, -β2, and β3 inhibit induction of macrophage nitrogen oxide synthesis, by IFN-γ. J. Immunol. 145-940-944.
16. Farrell. J. P., and C. E. Kirkpatrick. 1987. Experimental cutaneous leishmaniasis. II. A possible role for prostaglandins in exacerbation of disease in Leishmania major-infected BALB/e mice. J. Immunol. 138:902-907.
17. Furth, U., N. Solioz, and J. A. Louis. 1993. Leishmania major interferes with antigen presentation by infected macrophages. J. Immunol. 150:1857-1864.
18. Green, S. J., C. A. Nacy, and M. S. Meltzer. 1991. Cytokine-induccd synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens. J. Leukocyte Biol. 50:93-103.
19. Hall, L. R., and R. G. Titus. 1995. Sand fly vector saliva selectively modulates macrophage functions that inhibit killing of Leishmana major and nitric oxide production. J. Immunol. 155:3501-3506.
20. Heinel, F. P., R. M. Rerko, F. Ahmed, und E. Pearlman. 1995. Endogenous 1L-12 is required for control of Th2 cylokine responses capable of exacerbating leishnianiasis in normally resistant mice. J. Immunol. 155:730-739.
21. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gutely. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
22. Heinzel, F. P., M. D. Sadick, S. S. Mutha, and R. M. Locksley. 1991. Production of interferon γ, interleukin 2, interleukin 4 and interleukin 10 by CD4 lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015.
23. Kuchroo, V. K. C. A. Martin, J. M. Greer, S.-T. Ju, R. A. Sobel, and M. E. Dorf. 1993. Cytokincs and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol. 151:4371-4382.
24. +. Eur. J. Immunol. 25:3298-3307.
25. 2 production and antileishmanial capacity of human cultured monoeytes mediated by IFN-γy. J. Immunol. 143:3020-3024.
26. Liew, F. Y., and F. E. G. Cox. 1991. Nonspecific defence mechanism: the role of nitric oxide. Immunol. Today/Parasitol. Today (combined issue). 12:A17-A21.
27. Liew, F. Y., S. Millott, Y. Li, R. Lelchuk, W. L. Chan, and H. Ziltener. 1989. Macrophage activation by interferon-γ from host-protective T cells is inhibited by interleukin (IL) 3 and IL-4 produced by disease-promoting T cells in leishmaniasis. Eur. J. Immunol. 19:1227-1232.
28. Litchman, A. H., J. Chin, J. A. Schmidt, and A. K. Ahbas. 1988. Role of interleukin 1 in the activation of T lymphocytes. Proc. Natl. Acad. Sci. USA 85:9699-9703.
29. Lytton, S. D., E. Mnzes, and C. L. Jaffe. 1993. Effect of macrophage infection Leishmania on the proliferation of an antigen-specific T-cell line, TPBI. to a non-parasiie antigen, Parasite Immunol. 15:489-492.
30. + T cells. J. Immunol. 154:5071-5079.
31. Marchand, M., S. Daoud, R. G. Titus, J. Louis, and T. Boon. 1987. Variants with reduced virulence derived from Leishmania major after muthgen treatment. Parasite Immunol. 9:81-92.
32. 2 and agents that raise cAMP levels on macrophage activation induced by IFN-γ and TNF-α. J. Leukocyte Biol. 58:217-224.
33. Mauel, J., S. Betz-Corradin, and Y. Buchmuller-Rouiller. 1991. Nitrogen and oxygen metabolites and the killing of Leishmania by activated murine macrophages. Res. Immunol. 142:577-580.
34. 2 and LTB4 involvement in cutaneous leishmaniasis: relation with infection status and cytokine production. Parasitology 112:13-19.
35. Moll, H. 1993. Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis. Immunol. Today 14:383-386.
36. Moore, K. W., A. O'Garra, R. de W. Malefyt, P. Vieira, and T. R. Mosmann. 1993. lnterleukin-10. Annu. Rev. Immunol. 11:165-190.
37. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
38. Murray, H. W., B. Y. Rubin, and C. D. Rothermel. 1983. Killing of intracellular Leishmania donovani by lymphokine-stimulated human monocytes. Evidence that inlerferon γ is the aelivaling lymphokine. J. Clin. Invest. 72:1506-1510.
39. Nancy, C. A., A. H. Fortier, M. S. Meltzer, N. A. Buchmeler, and P. W. Gray, 1985. Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant intcrferon-γ and non-interfecron lymphokines. J. Immunol. 135:3505-3511.
40. Phipps, K. P., S. H. Stein, and R. L. Roper. 1991. A new view of prostaglandin E regulation of the immune response. Immunol. Today 12:349-352.
41. Prina, E., C. Jnuanne, S. Selma de Souza Lao, A. Szubo, J.-G, Guillet, and J. C. Antoine. 1993. Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes. J. Immunol. 151:2050-2061.
42. + T cells during initiation of infection. J. Exp. Med. 179:447-450.
43. Sadick, M. D., F. P. Heinzel, B. J. Holaday, R. T. Pu, R. S. Dawkins, and R. M. Locksley. 1990. Cure of murine Ieishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon γ-independent mechanism. J. Exp. Med. 171:115-127.
44. Sadick, M. D., R. M. Locksley, C. Tubbs, and H. V. Raff. 1986. Murine cutaneous leishmaniasis: resistance correlates wilh the capacity to generate interferon-γ in response to Leishmania antigens in vitro. J. Immunol. 136:655-661.
45. + T cell subsets and induces early resistance to Leislimania major in mice. J. Exp. Med. 178:507-577.
46. Scharton-Kersten, T., and P. Scott. 1995. The role of the innate immune response in Thl cell development following Leishmania major infection. J. Leukocyte Biol. 57:515-522.
47. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott, 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320-5330.
48. Scott, P. 1991. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147:3149-3155.
49. + T cells. Annu. Rev. Immunol. 12:635-074.
50. Shankar, A. H., and R. G. Titus. 1997. The influence of antigen presenting cell type and IFN-γ on priming and cytokine secretion of Leishmania major-specific T cells. J. Infect. Dis. 175:151-157.
51. +. major histocompatibility complex class II-restricted T cells derived in vitro from lymphoid tissues of naive mice. J. Exp. Med. 178:101-111.
52. Shankar, A. H., and R. G. Titus. 1995. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J. Exp. Med. 181:845-855.
53. c (low interferon-α/β) mice. Exp. Parasitol. 84:136-143.
54. Simon, A. K., K. Seipelt, and J. Sieper. 1994. Divergent T-cell cytokine patterns in inflammatory arthritis, Proc. Natl. Acad. Sci. USA 91:8562-8566.
55. Stenner, S., H. Thuring, M. Rollinghoff, and C. Bogdan. 1994. Tissue expression of indueible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 180:783-793.
56. Sypek, J. P., C. L. Chung, S. E. H. Muyor, J. M. Subramanyam, S. J. Goldman. D. S. Sieburth, S. K. Wolf, and R. G. Schaub. 1993. Resolution of cutaneos leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1747-1802.
57. Theodos, C. M., A. Shunkur, A. L. Glasebrook, W. D. Roeder, and R. G. Titus. 1994. The effect of treating with anti-interieukin-1receptor antibody on the course of experimental murine cutaneous leishmaniasis. Parasite Imnumol. 16:571-577.
58. Titus. K. G., A. Kelso, und J. A. Louis. 1984. Intracellular destruction of Leishmania tropica by macrophages activated with macrophage activating factor/interferon. Clin. Exp. Imnumol. 55:157-165.
59. Titus, R. G., C. M. Theodos, A. Shunkur, and L. R. Hall. 1994. Interactions between Leishmania major and macrophages, p. 437-454. In H. Zwilling and T. Eisenstein (ed.), Macrophage pathogen interactions. Marcel Dekker, New York, N.Y.
60. 2-dependent mechanism, J. Exp. Med. 180:1077-1086.
61. Vodovotz, Y., C. Bogdan, J. Paik, Q.-W. Xie, and C. Nathan. 1993. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J. Exp. Med. 178:605-613.
62. Weaver, C. T., C. M. Hawrylowicz, and E. R. Unanue. 1988. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 85:8181-8185.
63. Wenner, C. A., M. I. Guler, S. E. Macatonia, A. O'Garru, and K. M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-l development. J. Imnumol. 156:1442-1447.