메뉴 건너뛰기




Volumn 56, Issue 5, 1996, Pages 1131-1136

Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: Implications for the antitumor activity of interleukin 12 and/or interleukin 2

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 2;

EID: 0030056840     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (75)

References (60)
  • 1
    • 0027264849 scopus 로고
    • Interteukin-12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T cell-deficient hosts
    • Gazzinelli, R T., Hieny, S., Wynn, T. A., Wolf, S., and Sher, A. Interteukin-12 is required for the T-lymphocyte independent induction of interferon-γ by an intracellular parasite and induces resistance in T cell-deficient hosts. Proc. Natl. Acad Sci. USA, 90: 6115-6119, 1993.
    • (1993) Proc. Natl. Acad Sci. USA , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.A.3    Wolf, S.4    Sher, A.5
  • 2
  • 3
    • 0028208833 scopus 로고
    • Cytokine treatment of central nervous system infection: Efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis
    • Clemons, K. V., Brimmer, E., and Stevens, D. A. Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis. Antimicrob. Agents Chemother., 38: 460-464, 1994
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 460-464
    • Clemons, K.V.1    Brimmer, E.2    Stevens, D.A.3
  • 4
    • 0028071922 scopus 로고
    • In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS)
    • Gazzinelli, R T , Grese, N A , and Morse, H. C In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS). J. Exp. Med , 180: 2199-2208, 1994.
    • (1994) J. Exp. Med , vol.180 , pp. 2199-2208
    • Gazzinelli, R.T.1    Grese, N.A.2    Morse, H.C.3
  • 9
    • 0027933432 scopus 로고
    • Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells
    • Aste-Amezaga, M., D'Andrea, A., Kubin, M., and Trinchieri, G. Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells. Cell. Immunol , 156: 480-492, 1994
    • (1994) Cell. Immunol , vol.156 , pp. 480-492
    • Aste-Amezaga, M.1    D'Andrea, A.2    Kubin, M.3    Trinchieri, G.4
  • 10
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • Kobayashi, M , Fitz, L., Ryan, W., Hewick, R. M., Clark, S. C , Chan, S., Loudon, R , Sherman, F , Perussia, B., and Trinchien, G. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp. Med , 170: 827-845, 1989.
    • (1989) J Exp. Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, W.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchien, G.10
  • 15
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor interleukin 12 (IL-12) induces T helper type 1 (Th1)-specific immune response and inhibits the development of EL-4-producing Th cells
    • Manetti, R., Parronchi, P., Gludizi, M. G , Piccinni, M P., Maggi, E., Trinchieri, G., and Romagnani, S. Natural killer cell stimulatory factor interleukin 12 (IL-12) induces T helper type 1 (Th1)-specific immune response and inhibits the development of EL-4-producing Th cells. J. Exp. Med., 177: 1199-1204, 1993.
    • (1993) J. Exp. Med. , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Gludizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 16
    • 0027197436 scopus 로고
    • Interleukin-12/T cell stimulating factor: A cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells
    • Germann, T., Gately, M. K., Schoenhaut, D. S., Lohoff, M., Mattner, F., Fischer, S., Jin, S. C., Schmitt, E., and Rude, E. Interleukin-12/T cell stimulating factor: a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol , 23: 1826-1830, 1993
    • (1993) Eur. J. Immunol , vol.23 , pp. 1826-1830
    • Germann, T.1    Gately, M.K.2    Schoenhaut, D.S.3    Lohoff, M.4    Mattner, F.5    Fischer, S.6    Jin, S.C.7    Schmitt, E.8    Rude, E.9
  • 17
    • 0024208276 scopus 로고
    • Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate
    • Marletta, M. A., Yoon, P. S., Lyengar, R., Leaf, C. D., and Wishnok, J. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry, 27: 8706-8711, 1988.
    • (1988) Biochemistry , vol.27 , pp. 8706-8711
    • Marletta, M.A.1    Yoon, P.S.2    Lyengar, R.3    Leafc, D.4    Wishnok, J.5
  • 18
    • 0024385491 scopus 로고
    • Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components
    • Stuehr, D. J., Kwon, N. S , Gross, S. S., Thiel, B. A., Levi, R., and Nathan, C. F. Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem. Biophys. Res. Commun., 161: 420-426, 1989.
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 420-426
    • Stuehr, D.J.1    Kwon, N.S.2    Gross, S.S.3    Thiel, B.A.4    Levi, R.5    Nathan, C.F.6
  • 19
    • 0028270719 scopus 로고
    • Regulation and biosynthesis of nitric oxide
    • Nathan, C , and Xie, Q. Regulation and biosynthesis of nitric oxide J. Biol Chem., 269: 13725-13728, 1994.
    • (1994) J. Biol Chem. , vol.269 , pp. 13725-13728
    • Nathan, C.1    Xie, Q.2
  • 20
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
    • Ding, A. H., Nathan, C. F , and Stuehr, D. J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol., 141: 2407-2412, 1988.
    • (1988) J. Immunol. , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 21
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginine deiminase and imino nitrogen oxidation to nitrite
    • Washington DC
    • Hibbs, J. B , Jr, Taintor, R. R., and Vavrin, Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science (Washington DC), 235: 473-476, 1987.
    • (1987) Science , vol.235 , pp. 473-476
    • Hibbs Jr., J.B.1    Taintor, R.R.2    Vavrin, Z.3
  • 22
    • 0023250888 scopus 로고
    • Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-γ
    • Stuehr, D. I., and Marletta, M. A. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-γ. J. Immunol., 139: 518-525, 1987.
    • (1987) J. Immunol. , vol.139 , pp. 518-525
    • Stuehr, D.I.1    Marletta, M.A.2
  • 23
    • 0026442689 scopus 로고
    • Tumor necrosis factor-α-dependent production of reactive nitrogen intermediates mediates IFN-γ plus EL-2-induced murine macrophage tumoricidal activity
    • Cox, G. W., Melillo, G., Chattopadhyay, U., Mullet, D., Fertel, R. H., and Varesio, L. Tumor necrosis factor-α-dependent production of reactive nitrogen intermediates mediates IFN-γ plus EL-2-induced murine macrophage tumoricidal activity. J. Immunol., 149: 3290-3296, 1992.
    • (1992) J. Immunol. , vol.149 , pp. 3290-3296
    • Cox, G.W.1    Melillo, G.2    Chattopadhyay, U.3    Mullet, D.4    Fertel, R.H.5    Varesio, L.6
  • 24
    • 0023796162 scopus 로고
    • Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages
    • Drapier, J. C., Wietzerbin, J., and Hibbs, J. B., Jr. Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur J. Immunol., 18: 1587-1592, 1988.
    • (1988) Eur J. Immunol. , vol.18 , pp. 1587-1592
    • Drapier, J.C.1    Wietzerbin, J.2    Hibbs Jr., J.B.3
  • 25
    • 0028243464 scopus 로고
    • Regulation of nitric-oxide synthase mRNA expression by interferon-γ and picolinic acid
    • Melillo, G., Cox, G. W., Biragyn, A., Sheffler, L A., and Varesio, L. Regulation of nitric-oxide synthase mRNA expression by interferon-γ and picolinic acid J Biol. Chem., 269: 8128-8133, 1994.
    • (1994) J Biol. Chem. , vol.269 , pp. 8128-8133
    • Melillo, G.1    Cox, G.W.2    Biragyn, A.3    Sheffler, L.A.4    Varesio, L.5
  • 26
    • 0028302512 scopus 로고
    • Differential induction of nitric oxide synthase in various organs of the mouse during endotoxinemia: Role of TNF-α and IL-1-β
    • Cunha, F. Q., Assreuy, J., Moss, D. W., Rees, D., Leal, L. M. C., Moncada, S., Carrier, M., O'Donnell, C. A., and Liew, F. Y. Differential induction of nitric oxide synthase in various organs of the mouse during endotoxinemia: role of TNF-α and IL-1-β. Immunology, 81: 211-215, 1994.
    • (1994) Immunology , vol.81 , pp. 211-215
    • Cunha, F.Q.1    Assreuy, J.2    Moss, D.W.3    Rees, D.4    Leal, L.M.C.5    Moncada, S.6    Carrier, M.7    O'Donnell, C.A.8    Liew, F.Y.9
  • 28
    • 0027159607 scopus 로고
    • Picolinic acid, a catabolite of L-Tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages
    • Melillo, G., Cox, G. W., Radzioch, D. and Varesio, L. Picolinic acid, a catabolite of L-Tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages J. Immunol., 150: 4031-4040, 1993.
    • (1993) J. Immunol. , vol.150 , pp. 4031-4040
    • Melillo, G.1    Cox, G.W.2    Radzioch, D.3    Varesio, L.4
  • 29
    • 0028352123 scopus 로고
    • Macrophage-snmulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages
    • Wang, M H , Cox, G W., Yoshimura, T., Sheffler, L. A., Steel, A., and Leonard, E. J. Macrophage-snmulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages. J. Biol. Chem., 269: 14027-14031, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14027-14031
    • Wang, M.H.1    Cox, G.W.2    Yoshimura, T.3    Sheffler, L.A.4    Steel, A.5    Leonard, E.J.6
  • 31
    • 0028083246 scopus 로고
    • Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-α production role of tumor-derived IL-10, TGF-β and prostaglandin
    • Alleva, D. G., Burger, C. J., and Elgert, K. D Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-α production role of tumor-derived IL-10, TGF-β and prostaglandin. J. Immunol., 153: 1674-1686, 1994.
    • (1994) J. Immunol. , vol.153 , pp. 1674-1686
    • Alleva, D.G.1    Burger, C.J.2    Elgert, K.D.3
  • 32
    • 0028059949 scopus 로고
    • Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine
    • Calderòn, C. H., Huang, Z. H., Gage, D. A., Sotomayor, E. M., and Lopez, D. M. Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine. J. Exp. Med., 180: 945-958, 1994
    • (1994) J. Exp. Med. , vol.180 , pp. 945-958
    • Calderòn, C.H.1    Huang, Z.H.2    Gage, D.A.3    Sotomayor, E.M.4    Lopez, D.M.5
  • 34
    • 0021325847 scopus 로고
    • Biological activity of recombinant human interleukin 2 produced in Escherichia coli
    • Washington DC
    • Rosenberg, S. A., Grimm, E. A., McGrogan, M., Doyle, M., Kawasaki, E., Koths, K., and Mark, D. F. Biological activity of recombinant human interleukin 2 produced in Escherichia coli. Science (Washington DC), 223: 1412-1415, 1984.
    • (1984) Science , vol.223 , pp. 1412-1415
    • Rosenberg, S.A.1    Grimm, E.A.2    McGrogan, M.3    Doyle, M.4    Kawasaki, E.5    Koths, K.6    Mark, D.F.7
  • 35
    • 0021278528 scopus 로고
    • Site-specific mutagenesis of the human interleukin-2 gene: Structure-function analysis of the cysteine residues
    • Washington DC
    • Wang, A., Lu, S. D., and Mark, D. F. Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues. Science (Washington DC), 224: 1431-1433, 1984
    • (1984) Science , vol.224 , pp. 1431-1433
    • Wang, A.1    Lu, S.D.2    Mark, D.F.3
  • 36
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages comparison of activating cytokines and evidence for independent production
    • Ding, A H., Nathan, C F., and Steuhr, D. J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages comparison of activating cytokines and evidence for independent production. J. Immunol., 141: 2407-2412, 1988
    • (1988) J. Immunol. , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Steuhr, D.J.3
  • 37
    • 0024447719 scopus 로고
    • Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver
    • Cox, G. W., Mathieson, B. J., Gandino, L., Blasi, E., Radzioch, D., and Varesio, L. Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver. J Natl. Cancer Inst., 81: 1492-1496, 1989
    • (1989) J Natl. Cancer Inst. , vol.81 , pp. 1492-1496
    • Cox, G.W.1    Mathieson, B.J.2    Gandino, L.3    Blasi, E.4    Radzioch, D.5    Varesio, L.6
  • 39
    • 0025393642 scopus 로고
    • L-Arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages
    • Keller, R., Geiges, M., and Keist, R L-Arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages. Cancer Res., 50: 1421-1425, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 1421-1425
    • Keller, R.1    Geiges, M.2    Keist, R.3
  • 40
    • 0025300228 scopus 로고
    • Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine
    • Liew, F. Y., Millott, S., Parkinson, C., Plamer, R. M., and Moncada, S. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J. Immunol., 144: 4794-4797, 1990.
    • (1990) J. Immunol. , vol.144 , pp. 4794-4797
    • Liew, F.Y.1    Millott, S.2    Parkinson, C.3    Plamer, R.M.4    Moncada, S.5
  • 41
    • 0023142137 scopus 로고
    • L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
    • Hibbs, J. R., Jr., Vavrin, Z., and Taintor, R R. L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol., 138: 550-565, 1987.
    • (1987) J. Immunol. , vol.138 , pp. 550-565
    • Hibbs Jr., J.R.1    Vavrin, Z.2    Taintor, R.R.3
  • 42
    • 0018343414 scopus 로고
    • Extracellular cytolysis by activated macrophages and granulocytss I Pharmacologic triggering of effector cells and the release of hydrogen peroxide
    • Nathan, C. F., Brukner, L. H., Silverstein, S. C., and Cohn, Z. A. Extracellular cytolysis by activated macrophages and granulocytss I Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J. Exp. Med., 149: 84-99, 1979.
    • (1979) J. Exp. Med. , vol.149 , pp. 84-99
    • Nathan, C.F.1    Brukner, L.H.2    Silverstein, S.C.3    Cohn, Z.A.4
  • 43
    • 0020324680 scopus 로고
    • Mechanisms of target recognition and destruction in macrophage-mediated tumor cytotoxicity
    • Adams, D O , Johnson, W. J., and Marino, P. A. Mechanisms of target recognition and destruction in macrophage-mediated tumor cytotoxicity. Fed. Proc., 41: 2212-2221, 1981
    • (1981) Fed. Proc. , vol.41 , pp. 2212-2221
    • Adams, D.O.1    Johnson, W.J.2    Marino, P.A.3
  • 44
    • 0001108685 scopus 로고
    • Molecular mechanisms in tumor-cell killing by activated macrophages
    • Adams, D. O., and Nathan, C. F Molecular mechanisms in tumor-cell killing by activated macrophages. Immunol. Today, 4: 166-170, 1983
    • (1983) Immunol. Today , vol.4 , pp. 166-170
    • Adams, D.O.1    Nathan, C.F.2
  • 45
    • 0026059310 scopus 로고
    • Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma II. Down-regulation of macrophage mediated cytotoxiaty by tumor-derived granulocyte-macrophage colony-stimulating factor
    • Sotomayor, E. M., Fu, Y X., Lopez-Cepero, M., Herbert, L , Jiminez, J. J., Albarracin, C., and Lopez, D. M. Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma II. Down-regulation of macrophage mediated cytotoxiaty by tumor-derived granulocyte-macrophage colony-stimulating factor. J. Immunol., 147: 2816-2823, 1991.
    • (1991) J. Immunol. , vol.147 , pp. 2816-2823
    • Sotomayor, E.M.1    Fu, Y.X.2    Lopez-Cepero, M.3    Herbert, L.4    Jiminez, J.J.5    Albarracin, C.6    Lopez, D.M.7
  • 46
    • 0027368542 scopus 로고
    • Impaired activation of tumoricidal function in macrophages from mammary tumor bearers: The role of IFN-γ
    • Sotomayor, E. M., Cheng, X. F., Fu, Y. X., Hawkins, A , Calderòn, C., and Lopez, D M. Impaired activation of tumoricidal function in macrophages from mammary tumor bearers: the role of IFN-γ. Int J. Oncol., 3: 719-728, 1993.
    • (1993) Int J. Oncol. , vol.3 , pp. 719-728
    • Sotomayor, E.M.1    Cheng, X.F.2    Fu, Y.X.3    Hawkins, A.4    Calderòn, C.5    Lopez, D.M.6
  • 47
    • 26744464435 scopus 로고
    • The impaired tumoricidal function of macrophages from tumor bearing mice is related to defective nitric oxide production
    • Sotomayor, E. M., DiNapoli, M R , Lopez-Cepero, N., and Lopez, D. M. The impaired tumoricidal function of macrophages from tumor bearing mice is related to defective nitric oxide production. J. Immunol., 150: 58a, 1993.
    • (1993) J. Immunol. , vol.150
    • Sotomayor, E.M.1    DiNapoli, M.R.2    Lopez-Cepero, N.3    Lopez, D.M.4
  • 48
    • 0028302827 scopus 로고
    • Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms
    • Cui, S., Reichner, J. S., Mateo, R. B., and Albina, J. E. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res., 54: 2462-2467, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 2462-2467
    • Cui, S.1    Reichner, J.S.2    Mateo, R.B.3    Albina, J.E.4
  • 49
    • 0025938548 scopus 로고
    • Inhibition of tumor cell nbonucleotide reductase by macrophage-derived nitric oxide
    • Kwon, N. S , Stuehr, D. J., and Nathan, C. F Inhibition of tumor cell nbonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med., 174: 761-767, 1991.
    • (1991) J. Exp. Med. , vol.174 , pp. 761-767
    • Kwon, N.S.1    Stuehr, D.J.2    Nathan, C.F.3
  • 51
    • 0025788509 scopus 로고
    • Generation of EPR-detectable iron-nitrosyl complexes in tumor target cells cocultured with activated macrophages
    • Drapier, J. C., Pellat, C., and Yann, H. Generation of EPR-detectable iron-nitrosyl complexes in tumor target cells cocultured with activated macrophages. J. Biol. Chem., 266: 10162-10167, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10162-10167
    • Drapier, J.C.1    Pellat, C.2    Yann, H.3
  • 52
    • 0029016170 scopus 로고
    • Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362
    • Xie, K., Huang, S., Dong, Z., Gutman, M , and Fidler, I. J. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362 Cancer Res., 55: 3123-3131, 1995
    • (1995) Cancer Res. , vol.55 , pp. 3123-3131
    • Xie, K.1    Huang, S.2    Dong, Z.3    Gutman, M.4    Fidler, I.J.5
  • 53
    • 0028929559 scopus 로고
    • Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells
    • Xie, K., Huang, S., Dong, Z , Juang, S. H., Gutman, M., Zie, Q., Nathan, C., and Fidler, I. J. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J. Exp. Med., 181: 1333-1343, 1995.
    • (1995) J. Exp. Med. , vol.181 , pp. 1333-1343
    • Xie, K.1    Huang, S.2    Dong, Z.3    Juang, S.H.4    Gutman, M.5    Zie, Q.6    Nathan, C.7    Fidler, I.J.8
  • 55
    • 0028265599 scopus 로고
    • Production of angiogemc activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism
    • Leibovich, S. J., Polverim, P. J., Fong, T. W., Harlow, L. A., and Koch, A. E. Production of angiogemc activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism. Proc. Natl. Acad. Sci. USA, 91: 4190-4194, 1994
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4190-4194
    • Leibovich, S.J.1    Polverim, P.J.2    Fong, T.W.3    Harlow, L.A.4    Koch, A.E.5
  • 58
    • 0002215348 scopus 로고
    • Oral N-nitro-L-arginine methyl ester administration slows the growth of malignant tumours in rodents
    • Kennovin, G. D., Hirst, D. G., and Flitney, F. W. Oral N-nitro-L-arginine methyl ester administration slows the growth of malignant tumours in rodents. Endothelium , 1: S52, 1993.
    • (1993) Endothelium , vol.1
    • Kennovin, G.D.1    Hirst, D.G.2    Flitney, F.W.3
  • 60
    • 0030067276 scopus 로고    scopus 로고
    • Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma
    • Wigginton, J. M , Komschlies, K L., Back, T. C., Franco, J L , Brunda, M. J., and Wiltrout, R H. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma. J. Natl. Cancer Inst., 88: 38-43, 1996
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 38-43
    • Wigginton, J.M.1    Komschlies, K.L.2    Back, T.C.3    Franco, J.L.4    Brunda, M.J.5    Wiltrout, R.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.