Multipoint linkage-disequilibrium - Mapping approach based on the case-parent trio design

American Journal of Human Genetics

Volumn 68, Issue 4, 2001, Pages 937-950

  Liang, Kung Yee ^a   Hsu, Fang Chi ^a   Beaty, Terri H ^b   Barnes, Kathleen C ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; HEREDITY; HETEROZYGOSITY; MARKER GENE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0035075317     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/319504     Document Type: Article

References (51)

1. Dense mapping of chromosome 12q3.12-q23.3 and linkage to asthma and atopy
2. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
3. Genetic association mapping based on discordant sib pairs: The discordant-alleles test
4. Genomewide transmission/disequilibrium testing - Consideration of the genotypic relative risks at disease loci
5. Transmission/disequilibrium tests for extended marker haplotypes
6. Exact transmissiondisequilibrium tests with multiallelic markers
7. Fieller's theorem and linkage disequilibrium mapping
8. A comparison of linkage disequilibrium measures for fine-scale mapping
9. Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations
10. Disequilibrium likelihoods for fine-scale mapping of a rare allele
11. Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland
12. Maximum-likelihood estimation of gene location by linkage disequilibrium
13. A discordant-sibship test for disequilibrium and linkage: No need for parental data
14. Likelihood methods for locating disease genes in nonequilibrium populations
15. Power studies for the transmission/disequilibrium tests with multiple alleles
16. A note on power approximations for the transmission/disequilibrium test
17. The haplotype-relative-risk (HRR) method for analysis of association in nuclear families
18. Linkage disequilibrium and gene mapping: An empirical least-squares approach
19. A conditional inference framework for extending the transmission/disequilibrium test
20. A robust identity by descent procedure using affected sib pairs: Multipoint mapping for complex diseases
21. A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sib pairs
22. Longitudinal data analysis using generalized linear models
23. Multivariate regression analysis for categorical data
24. A test for linkage and association in general pedigrees: The pedigree disequilibrium test
25. Hidden linkage: A comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT)
26. Two-locus models of disease
27. Statistical properties of the haplotype relative risk
28. Statistical approaches to gene mapping
29. Correlated binary regression with covariates specific to each binary observation
30. Likelihood analysis of disequilibrium mapping, and related problems
31. Linkage strategies for genetically complex traits. I. Multilocus models
32. The future of genetic studies of complex human diseases
33. General score tests for associations of genetic markers with disease using cases and their parents
34. Transmission disequilibrium, family controls, and great expectations
35. Use of parents, sibs, and un-related controls for detection of associations between genetic markers and disease
36. Statistics in human genetics
37. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
38. Effect of allelic heterogeneity on the power of the transmission disequilibrium test
39. The TDT and other family-based tests for linkage disequilibrium and association
40. A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test
41. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
42. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
43. A haplotype-based haplotype relative risk approach to detecting allelic associations
44. Mapping disease genes: Family-based association studies
45. Power of association and linkage tests when the disease alleles are unobserved
46. The problems of using the transmission/disequilibrium test to infer tight linkage
47. The effect of family structure on linkage tests using allelic association
48. Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
49. The power of linkage detection by the transmission/disequilibrium tests
50. Transmission/disequilibrium tests using multiple tightly linked markers
51. Multipoint linkage disequilibrium mapping with particular reference to the African-American population