A robust identity-by-descent procedure using affected sib pairs: Multipoint mapping for complex diseases

Human Heredity

Volumn 51, Issue 1-2, 2001, Pages 64-78

  Liang, Kung Yee ^a   Chiu, Yen Feng ^a   Beaty, Terri H ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Affected sib pairs; Generalized estimating equations; Identity by descent; Multipoint; Robustness; Sample size and power

Indexed keywords

ALLELE; ARTICLE; CALCULATION; CHROMOSOME ANALYSIS; COMPUTER PROGRAM; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; SIBLING;

CHROMOSOME MAPPING; GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; MODELS, STATISTICAL; NUCLEAR FAMILY;

EID: 0035205458     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022961     Document Type: Article

References (23)

1. Goldin LR: Detection of linkage under heterogeneity: comparison of two-locus vs. Admixture models. Genet Epidemiol 1992;9:61-66.
2. Haldane JBS: The combination of linkage values and the calculation of distances between the loci of linked factors. J Genet 1919;8:299-309.
3. Haseman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972;2:3-19.
4. Hauser ER, Boehnke M: Genetic linkage analysis of complex genetic traits by using affected sibling pairs. Biometrics 1998;54:1238-1246.
5. Hodge SE, Elston R: Lods, wrods, and mods: The interpretation of lod scores calculated under different models. Genet Epidemiol 1994;11: 329-342.
6. Hodge SE, Vieland VJ: The essence of single ascertainment. Genetics 1996;144:1214-1223.
7. Huber PJ: Robust estimation of a location parameter. Ann Math Statist 1964;35:73-101.
8. Huber PJ: The behavior of maximum likelihood estimators under non-standard conditions. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, 1967, vol 1, pp 221-233.
9. Kong A, Cox NJ: Allele-sharing models: Lod scores and accurate linkage tests. Am J Hum Genet 1997;61:1179-1188.
10. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
11. Lander ES, Kruglyak L: Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 1995;11: 241-247.
12. Liang KY, Rathouz PJ, Beaty TH: Determining linkage and mode of inheritance: Mod scores and other methods. Genet Epidemiol 1996;13: 575-593.
13. Liang KY, Zeger SL: Longitudinal data analysis using generalized linear models. Biometrika 1986;73:13-22.
14. MacLean CJ, Bishop DT, Sherman SL, Diehl SR: Distribution of lod scores under uncertain mode of inheritance. Am J Hum Genet 1993; 52:354-361.
15. Risch N: Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990a;46:222-228.
16. Risch N: Linkage strategies for genetically complex traits: II. The power of affected relative pairs. Am J Hum Genet 1990b;46:229-241.
17. Schork NJ, Boehnke M, Terwilliger JD, Ott J: Two-trait-locus linkage analysis: A powerful strategy for mapping complex genetic traits. Am J Hum Genet 1993;53:1127-1136.
18. Smith CAB: Testing for heterogeneity of recombination fraction values in human genetics. Ann Hum Genet 1963;27:175-182.
19. Suarez BK, Rice J, Reich T: The generalized sib pair IBD distribution: Its use in the detection of linkage. Am Hum Genet 1978;42:87-94.
20. Teng J, Siegmund D: Multipoint linkage analysis using affected relative pairs and partially informative markers. Biometrics 1998;54:1247-1265.
21. Vieland VJ, Hodge SE, Greenberg DA: Adequacy of single-locus approximations for linkage analysis of oligogenic traits. Genet Epidemiol 1992; 9:45-59.
22. Whittemore AS: Genome scanning for linkage: An overview. Am J Hum Genet 1996;59:704-716.
23. Whittemore AS, Halpern J: A class of tests for linkage using affected pedigree members. Biometrics 1994;50:118-127.