Exact transmission-disequilibrium tests with multiallelic markers

Genetic Epidemiology

Volumn 14, Issue 4, 1997, Pages 337-347

  Cleves, Mario A ^a   Olson, Jane M ^a,b   Jacobs, Kevin B ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dept Epidemiol Biostatist R 255 ^*  (United States)

Author keywords

Gene mapping; Linkage; Markov chain; Monte Carlo; Randomization tests

Indexed keywords

ALGORITHM; ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC MARKER; HUMAN; PROBABILITY; PROGENY; SIBLING;

ALGORITHMS; ALLELES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MARKOV CHAINS; MODELS, GENETIC; MODELS, STATISTICAL; MONTE CARLO METHOD; NUCLEAR FAMILY; POLYMORPHISM, GENETIC; RISK ASSESSMENT;

EID: 0030747762     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:4<337::AID-GEPI1>3.0.CO;2-0     Document Type: Article

References (9)

1. Bickeboller H, Clerget-Darpoux F (1995): Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers. Genet Epidemiol 12:865-870.
2. Blackwelder WC, Elston RC (1985): A comparison of sib-pair linkage test for disease susceptibility loci. Genet Epidemiol 2:85-97.
3. Breslow NE, Day NE (1980): "Statistical Methods in Cancer Research. Vol I. The Analysis of CaseControl Studies." Lyon, France: International Agency for Research on Cancer, pp 182-189.
4. Ott J (1989): Statistical properties of the haplotype relative risk. Genet Epidemiol 6:127-130.
5. Rice JP, Newman RJ, Hoshaw SL, Daw EW, Gu C (1995): TDT with covariates and genomic screens with mod scores: Their behavior on simulated data. Genet Epidemiol 12:659-664.
6. Schaid DJ, Sommer SS (1993): Genotype relative risks: Methods for design and analysis of candidategene association studies. Am J Hum Genet 53:1114-1126.
7. Spielman RS, Ewens WJ (1996): The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
8. Spielman RS, McGínnís RE, Ewens WJ (1993): Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516.
9. Statistical Analysis for Genetic Epidemiology (SAGE) (1997): Software package available from the Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.