Hidden linkage: A comparison of the affected sib pair (ASP) test and transmission/disequilibrium test (TDT)

Annals of Human Genetics

Volumn 62, Issue 2, 1998, Pages 159-179

  McGinnis, R E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFFECTED SIB PAIR TEST; ALLELE; ARTICLE; DISEASE TRANSMISSION; DISEQUILIBRIUM TEST; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; MARKER GENE; PRIORITY JOURNAL; PROBABILITY; STATISTICAL ANALYSIS;

GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; MODELS, STATISTICAL; NUCLEAR FAMILY;

EID: 0031659139     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480098006800     Document Type: Article

References (22)

1. BELL, G. I., HORITA, S. & KARAM, J. H. (1984) A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33, 176-183.
2. BLACKWELDER, W. C. & ELSTON, R. C. (1985) A comparison of sib-pair linkage tests for susceptibility loci. Genet. Epidemiol. 2, 85-97.
3. CLERGET-DARPOUX, F., BABRON, M. C. & BICKEBÖLLER, H. (1995) Comparing the power of linkage detection by the transmission disequilibrium test and identity-by-descent test. Genet. Epidemiol. 12, 583-588.
4. COX, N. J. & SPIELMAN, R. S. (1989) The insulin gene and susceptibility to IDDM. Genet Epidemiol 6, 65-69.
5. EWENS, W. J. & SPIELMAN, R. S. (1997) Disease associations and the transmission/disequilibrium test (TDT). Current Protocols in Human Genetics 1.12.1-1.12.13.
6. JULIER, C., HYER, R. N., DAVIES, J., MERLIN, F., SOULARUE, P., BRIANT, L., CATHELINEAU, G., et al. (1991) Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 354, 155-159.
7. KAPLAN, N. L., MARTIN, E. R. & WEIR, B. S. (1997) Power studies of the transmission/disequilibrium tests with multiple alleles. Am. J. Hum. Genet. 60, 691-702.
8. MCGINNIS, R. E., SPIELMAN, R. S. & EWENS, W. J. (1991) Linkage between the insulin gene (IG) region and susceptibility to insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. Suppl. 49, A476.
9. MÜLLER-MYSHSOK, B. & ABEL, L. (1997) Genetic analysis of complex diseases. Science 275, 1328-1329.
10. OTT, J. (1989) Statistical properties of the haplotype relative risk. Genet. Epidemiol. 6, 127-130.
11. OTT, J. (ed) (1991) Analysis of human genetic linkage. Johns Hopkins University Press, Baltimore.
12. RISCH, N. (1990) Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46, 229-241.
13. RISCH, N. & MERIKANGAS, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516-1517.
14. PEARSON, E. S. & HARTLEY, H. O. (ed) (1954) Biometrika tables for statisticians. Vol 1. Cambridge University Press.
15. SCHAID, D. J. & SOMMER, S. S. (1994) Comparison of statistics for candidate-gene association studies using cases and parents. Am. J. Hum. Genet. 55, 402-409.
16. SHAM, P. C. & CURTIS, D. (1995) An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann. Hum. Genet. 59, 323-336.
17. SPIELMAN, R. S., BAUR, M. P. & CLERGET-DARPOUX, F. (1989). Genetic analysis of IDDM: summary of GAW5 IDDM results. Genet. Epidemiol. 6, 43-58.
18. SPIELMAN, R. S., MCGINNIS, R. E. & EWENS, W. J. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516.
19. SPIELMAN, R. S. & EWENS, W. J. (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am. J. Hum. Genet. 59, 983-989.
20. TERWILLIGER, J. D. & OTT, J. (1992) A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum. Hered. 42, 337-346.
21. THOMSON, G., ROBINSON, W. P., KUHNER, M. K. & JOE, S. (1989) HLA, insulin gene, and Gm associations with IDDM. Genet. Epidemiol. 6, 155-160.
22. WEIR, B. S. (ed) (1996) Genetic data analysis II, 2nd ed., Sinauer Associates Inc., Sunderland, MA.