Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy

Journal of Allergy and Clinical Immunology

Volumn 104, Issue 2 I, 1999, Pages 485-491

  Barnes, Kathleen C ^a,h   Freidhoff, Linda R ^a   Nickel, Renate ^a   Chiu, Yen Feng ^b   Juo, Suh Hang ^b,c   Hizawa, Nobuyuki ^a,d   Naidu, Raana P ^e   Ehrlich, Eva ^a   Duffy, David L ^b,f   Schou, Carsten ^g   Levett, Paul N ^e   Marsh, David G ^a   Beaty, Terri H ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d HOKKAIDO UNIVERSITY   (Japan)

^e UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^g ALK ABELLÓ   (Denmark)

^h JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Allergic rhinitis; Asthma; Chromosome 12q; IFN ; Linkage analysis

Indexed keywords

GAMMA INTERFERON; MICROSATELLITE DNA; STAT6 PROTEIN;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; ATOPY; CHROMOSOME 12Q; CHROMOSOME MAP; CONTROLLED STUDY; DNA DETERMINATION; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE LINKAGE GROUP; GENE LOCATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0032873530     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(99)70398-2     Document Type: Article

References (53)

1. Holgate ST. Asthma genetics: waiting to exhale. Nat Genet 1997;15:227-9.
2. Daniels SE, Bhattacharrya S, James A, et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996;383:247-50.
3. Anonymous. The Collaborative Study on the Genetics of Asthma: a genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997;15:389-92.
4. Barnes KC, Neely JD, Duffy DL, et al. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: evidence from Afro-Caribbean and Caucasian populations. Genomics 1996;37:41-50.
5. Wilkinson J, Thomas NS, Lio P, Doull I, Holgate ST, Morton NE. Evidence for linkage between markers on chromosome 12q and asthma and atopy in 191 families [abstract]. Am J Respir Crit Care Med 1997;155:A257.
6. Nickel R, Wahn U, Hizawa N, et al. Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study (MAS '90). Genomics 1997;46:159-62.
7. Krauter K, Montgomery K, Yoon S-J, et al. A second-generation YAC counting map of human chromosome 12. Nature 1995;377(Suppl):321-33.
8. Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 STAT. Science 1994;265:1701-6.
9. Takeda K, Tanaka T, Shi W, et al. Essential role of Stato in IL-4 signalling. Nature 1996;380:627-30.
10. Lin JX, Migone TS, Tsang M, et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 1995;2:331-9.
11. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 1996;157:3220-2.
12. Svaren J, Apel ED, Simburger KS, et al. The Nab2 and Stat6 genes share a common transcription termination region. Genomics 1997;41:33-9.
13. Grossman J. One airway, one disease. Chest 1997;111:11S-6S.
14. Naclerio RM, Proud D, Togias AG, et al. Inflammatory mediators in late antigen-induced rhinitis. N Engl J Med 1985;313:65-70.
15. Bascom R, Piplorn U, Lichtenstein LM, Naclerio RM. The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of steroid pretreatment. Am Rev Respir Dis 1988;138:406-12.
16. Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
17. Bradding P, Feather IH, Wilson S, Bardin P, Holgate ST, Howarth PH. Immunolocalisation of cytokines in the nasal mucosa of normal and perennial rhinitic subjects: the mast cell as a source of IL-4, IL-5 and IL-6 in human allergic inflammation. J Immunol 1993;151:3853-65.
18. Redington AE, Bradding P, Douglass JA, et al. Bronchial epithelial cytokine production in asthmatics and non-asthmatics. Thorax 1993;48:1081.
19. Howarth PH, Bradding P, Montefort S, et al. Mucosal inflammation and asthma. Am J Respir Crit Care Med 1994;150:818-22.
20. Krug N, Madden J, Redington AE, et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996;14:319-26.
21. Kjellman NI. Is there a place for antihistamines in the treatment of perennial asthma? Pediatr Allergy Immunol 1993;4(Suppl):38-43.
22. Holgate ST, Finnerty JP Antihistamines in asthma. J Allergy Clin Immunol 1989;83(Suppl):537-47.
23. Creticos PS, Peters SP, Adkinson NFJ, et al. Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. N Engl J Med 1984;310:1626-30.
24. Wang D, Clement P, Smitz J, et al. Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. Eur Arch Otorhinolaryngol 1995;1:S40-3.
25. Naclerio RM, Baroody FM, Togias AG. The role of leukotrienes in allergic rhinitis: a review. Am Rev Respir Dis 1991;143(Suppl):S91-5.
26. 4 from granulocytes of normal controls, allergic rhinitis, and asthmatic subjects. Ann Allergy 1990;65:228-32.
27. Henderson WR. Role of leukotrienes in asthma. Ann Allergy 1994;72:272-8.
28. Bentley AM, MenzG, Storz CHR, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Am Rev Respir Dis 1992;146:500-6.
29. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow J-CJ. Allergic and nonallergic asthmatics have distinct patterns of T-Cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992;146:109-15.
30. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154:1479-504.
31. Humbert M, Ying S, Corrigan C, et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 1997;16:1-8.
32. Blumenthal MN, Banks-Schlegel S, Bleeker ER, Marsh DG, Ober C. Collaborative studies on the genetics of asthma-National Heart, Lung, and Blood Institute. Clin Exp Allergy 1995;25:29-32.
33. Marsh DG, Neely JD, Breazeale DR, et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152-6.
34. Kleine-Tebbe J, Eickholt M, Gatjen M, Brunnee T, O'Connor A, Kunkel G. Comparison between MAGIC LITE- and CAP-system: two automated specific IgE antibody assays. Clin Exp Allergy 1992;22:475-84.
35. Rasp G. Allergic rhinopathy: Magic Lite SQ Allergy Screen Inhalant and CAP-FEIA SX1 - comparison of two allergen-specific screening tests in serum, [in German], Laryngorhinootologie 1992;71:298-301.
36. Onoue Y, Murakami G, Takano M, et al. Evaluation of the Magic Lite SQ specific IgE kit [in Japanese]. Arerugi 1993;42:846-53.
37. SYSTAT. SYSTAT for Windows. Evanston (IL): SYSTAT, Inc; 1992.
38. Green P, Falls K, Crooks S. Cri-Map. St. Louis: Washington University; 1990.
39. SAGE. Statistical Analysis for Genetic Epidemiology. New Orleans: Department of Biometry and Genetics, Louisiana State University Medical Center; 1992.
40. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and non-parametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996;58:1347-63.
41. Asderakis A, Pravica V, Dyer PA, Sinnott PJ, Hutchinson IV. CA repeat polymorphism in the first intron of the interferon-γ (IFN-γ) gene. Immunology 1997;92(Suppl):62.
42. Duffy DL. SIB-PAIR 0.98.8. A program for elementary genetical analysis. Herston, Queensland: Queensland Institute of Medical Research; 1995-1999.
43. Gray PW, Goeddel DV. Human immune interferon (IFN-gamma) gene sequence and structure. Basic Life Sc 1983;25:35-61.
44. Awata T, Matsumoto C, Urakami T, Hagura R, Amemiya S, Kanazawa Y Association of polymorphism in the interferon gamma gene with IDDM. Diabetologia 1994;37:1159-62.
45. Pociot F, Veijola R, Johannesen J, et al. Analysis of an interferon-gamma gene (IFNG) polymorphism in Danish and Finnish insulin-dependent diabetes mellitus (IDDM) patients and control subjects. Danish Study Group of Diabetes in Childhood. J Interferon Cytokine Res 1997;17:87-93.
46. Hayden C, Pereira E, Rye P, et al. Mutation screening of interferon-gamma (IFNgamma) as a candidate gene for asthma. Clin Exp Allergy 1997;27:1412-6.
47. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-16.
48. Ott J. Computer-simulation methods in human linkage analysis. Proc Nat Acad Sci USA 1989;86:4175-8.
49. Smith JM. Epidemiology and natural history of asthma, allergic rhinitis, and atopic dermatitis (eczema). In: Middleton E Jr, Reed CE, Ellis EF, editors. Allergy: principles and practice. St. Louis: Mosby; 1983. p. 771-803.
50. Settipane RJ, Hagy GW, Settipane GA. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc 1994;15:21-5.
51. Rimpela AH, Savonius B, Rimpela MK, et al. Asthma and allergic rhinitis among Finnish adolescents in 1977-1991. Scand J Soc Med 1995;23:60-5.
52. Braman SS, Barrows AA, DeCotiis BA, et al. Airway hyperresponsiveness in allergic rhinitis: a risk factor for asthma. Chest 1987;91:671-4.
53. Kapsali T, Horowitz E, Diemer F, Togias A. Rhinitis is ubiquitous in allergic asthmatics. J Allergy Clin Immunol 1997;99:S138.