The power of linkage detection by the transmission/disequilibrium tests

Human Heredity

Volumn 48, Issue 6, 1998, Pages 295-312

  Xiong, Momiao ^a   Guo, Sun Wei ^b,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Association study; Linkage disequilibrium; Population genetics; Power disequilibrium test

Indexed keywords

ALLELE; ARTICLE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC PARAMETERS; GENETIC RECOMBINATION; HUMAN; MARKER GENE;

CHROMOSOME MAPPING; GENE FREQUENCY; GENES, DOMINANT; GENES, RECESSIVE; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; MUTATION; RECOMBINATION, GENETIC;

EID: 0031793251     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022821     Document Type: Article

References (31)

1. Bickeböller H, Clerget-Darpoux F: Statistical properties of the allelic and genotypic transmission disequilibrium test for multiallelic markers. Genet Epidemiol 1995;12:865-870.
2. Camp NJ: Genomewide transmission/disequilibrium testing-consideration of the genotypic relative risks at disease loci. Am J Hum Genet 1997;61:1424-1430.
3. Clerget-Darpoux F, Babron M-C, Bickeböller H: Comparing the power of linkage detection by the transmission disequilibrium test and the identity-by-descent test. Genet Epidemiol 1995;12:583-588.
4. Collins FS, Guyer MS, Chakravarti A: Variation on a theme: Cataloging human DNA sequence variation. Science 1997;278:1580-1581.
5. Devlin B, Risch N: A comparison of linkage disequilibrium measures for finescale mapping. Genomics 1995; 29:311-322.
6. Ewens WJ, Spielman RS: The transmission/disequilibrium test: History, subdivision, and admixture. Am J Hum Genet 1995;57:455-464.
7. Falk CT, Rubinstein P: Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 1987;51:227-233.
8. Guo SW: Linkage disequilibrium measures for fine-scale mapping: A comparison. Hum Hered 1997;47:301-314.
9. Hedrick PW. Gametic disequilibrium measures: Proceed with caution. Genetics 1987;117:331-341.
10. Kaplan NL, Hill WG, Weir BS: Likelihood methods for locating disease genes in nonequilibrium populations. Am J Hum Genet 1995;56: 18-32.
11. Kaplan NL, Martin ER, Weir BS: Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet 1997;60: 691-702.
12. Knapp M, Seuchter SA, Baur MP: The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 1993;52:1085-1093.
13. Lewontin RC: On measures of gametic disequilibrium. Genetics 1988;120: 849-852.
14. Müller-Myhsok B, Abel L: Genetic analysis of complex disease. Science 1997;275:1328-1329.
15. Ohta T, Kimura M: A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population Genet Res 1973;22:201-204.
16. Ott J: Statistical properties of the haplotype relative risk. Genet Epidemiol 1989;6:127-130.
17. Ott J, Rabinowitz D: The effect of marker heterozygosity on the power to detect linkage disequilibrium. Genetics 1997;147:927-930.
18. Risch N: Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46: 222-228.
19. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996;273:1516-1517.
20. Rubinstein P, Walker M, Carpenter C, Carrier C, Krassner J, Falk C, Ginsberg F: Genetics of HLA disease associations: The use of the haplotype relative risk (HRR) and the 'haplo-delta' (Dh) estimates in juvenile diabetes from three racial groups. Hum Immunol 1981;3:384.
21. Schaid DJ: General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 1996;13:423-449.
22. Schaid DJ, Sommer SS: Genotype relative risks: Methods for design and analysis of candidate-gene association studies. Am J Hum Genet 1993;53:1114-1126.
23. Sham PC, Curtis D: An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 1995;59:323-336.
24. Shriver MD, Jin L, Chakraborty R, Boerwinkie E: VNTR allele frequency distributions under the stepwise mutation model: A computer simulation approach. Genetics 1993;134: 983-993.
25. Spielman RS, Ewens WJ: The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 1996;59:983-989
26. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516.
27. Terwilliger J, Ott J: A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum Hered 1992;42:337-346.
28. Thomson G: Analysis of complex human genetic traits. An ordered-notation method and new tests for mode of inheritance. Am J Hum Genet 1995;47:474-486
29. Valdes AM, Slatkin M, Freimer N: Allele frequencies at microsatellite loci: The stepwise model revisited. Genetics 1993;133:737-749.
30. Xiong MM, Guo SW: Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications. Am J Hum Genet 1997;60:1513-1531.
31. Xiong MM, Guo SW: A general stepwise mutation model for simple sequence repeats, submitted.