Biomarker monitoring for health risk based on sensitivity to environmental mutagens

Reviews on Environmental Health

Volumn 16, Issue 1, 2001, Pages 41-64

  Au, W W ^a   Oberheitmann, B ^a   Heo, M Y ^a   Hoffmann, W ^a   Oh, H Y ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Cancer; Challenge assay; Chromosome aberrations; DNA repair; FISH; Mutagen sensitivity; Population monitoring

Indexed keywords

ENVIRONMENTAL MUTAGEN;

BIOASSAY; CHROMOSOME ABERRATION; DISEASE PREDISPOSITION; DNA REPAIR; ENVIRONMENTAL MONITORING; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC SUSCEPTIBILITY; GENOME; HEALTH HAZARD; HUMAN; PROVOCATION TEST; REVIEW;

EID: 0035058271     PISSN: 00487554     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVEH.2001.16.1.41     Document Type: Review

References (127)

1. New goals for the U.S. human genome project: 1998-2003
2. Monitoring human populations for effects of radiation and chemical exposures using cytogenetic techniques
3. Future research directions for evaluating human genetic and cancer risk from environmental exposures
4. Strategies for conducting human population monitoring studies
5. Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism
6. The role of individual susceptibility in cancer burden related to environmental exposure
7. Factors that influence the DNA repair capacity of normal and skin cancer-affected individuals
8. Inheritance of polymorphic metabolizing genes on environmental disease and quality of life
9. Cancer-susceptibility genes. Gatekeepers and caretakers
10. Transient expression of a mutator phenotype in cancer cells
11. Genetic instability in colorectal cancers
12. Genes which increase chromosomal instability in somatic cells and predispose to cancer
13. Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy
14. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
15. Molecular genetics of Bloom's syndrome
16. MED1, a novel human methyl-Cp-G-binding endonuclease, interacts with DNA mismatch repair protein (MLH1)
17. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
18. Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours
19. Cancer risk in mutation carriers of DNA-mismatch-repair genes
20. DNA repair proficiency in breast cancer patients and their first-degree relatives
21. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
22. Deficient DNA repair capacity, a predisposing factor in breast cancer
23. Genetic predisposition in breast cancer
24. Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: A test for predisposition?
25. Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer
26. Heritability of cellular radiosensitivity: A marker of low-penetrance predisposition genes in breast cancer?
27. Reduced DNA repair capacity in lung cancer patients
28. DNA repair proficiency: Potential susceptibility factor for breast cancer
29. X-ray-induced chromatid damage in relation to DNA repair and cancer incidence in family members
30. The incidence and gene frequency of ataxia-telangiectasia in the United States
31. Breast and other cancers in families with ataxia-telangiectasia
32. Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay
33. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
34. Variation in DNA repair is a factor in cancer susceptibility: A paradigm for the promises and perils of individual and population risk estimation?
35. Oncogenic base substitution mutation frequencies in circulating leukocytes of normal individuals
36. Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcinogenesis
37. Mutagen-induced chromosome fragility within peripheral blood lymphocytes of head and neck cancer patients
38. DNA repair capacity as a risk factor for non-melanocytic skin cancer - A molecular epidemiological study
39. Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma
40. Hypersensitivity to ionizing radiation, in vitro, in a new chromosomal breakage disorder, the Nijmegen Breakage Syndrome
41. Carrier detection in xeroderma pigmentosum
42. Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: Chromosome aberrations after low dose-rate irradiation
43. Cytogenetic investigations in a family with ataxia telangiectasia
44. Radiation-induced comet-formation in human skin fibroblasts from radiotherapy patients with different normal tissue reactions
45. Chromosomal in-vitro radiosensitivity of lymphocytes in radiotherapy patients and AT-homozygotes
46. Chromosome aberrations and response to gamma-ray challenge in lymphocytes of workers exposed to 1,3-butadiene
47. Measurement of DNA repair deficiency in workers exposed to benzene
48. Abnormal DNA repair activities in lymphocytes of workers exposed to 1,3-butadiene
49. Factors contributing to chromosome damage in lymphocytes of cigarette smokers
50. Population monitoring: Experience with residents exposed to uranium mining/milling waste
51. Distress and DNA repair in human lymphocytes
52. Cytogenetic analysis of chromosome instabilities in human populations
53. G2 chromosomal radiosensitivity of ataxia-telangiectasia heterozygotes
54. The contribution of deficient DNA repair to chromosomal radiosensitivity of CHO cells after G2 irradiation
55. Chromosomal radiosensitivity of Down syndrome lymphocytes at different stages of the cell cycle
56. Distribution of x-ray-induced chromosome breakpoints in Down syndrome lymphocytes
57. Chromosomal radiosensitivity of lymphocytes from skin cancer-prone patients
58. Risk factors and genetic susceptibility
59. Chromosome sensitivity to bleomycin-induced mutagenesis, an independent risk factor for upper aerodigestive tract cancers
60. Mutagen sensitivity in upper aerodigestive tract cancer: A case-control analysis
61. Mutagen sensitivity in patients with head and neck cancers: A biologic marker for risk of multiple primary malignancies
62. Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract
63. Three measures of mutagen sensitivity in a cancer-free population
64. Inherited susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes
65. Genetics of smoking-related cancer and mutagen sensitivity
66. Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. I. Correlation with chromosomal aberrations
67. Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II. Relationship to baseline SCE frequency
68. Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to 'spontaneous' sister chromatid exchange frequencies in human lymphocytes
69. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers
70. Development and field-test validation of an assay for DNA repair in circulating human lymphocytes
71. DNA repair and aging in basal cell carcinoma: A molecular epidemiology study
72. DNA repair and epidemiology of basal cell carcinoma
73. The role of DNA repair capacity in susceptibility to lung cancer: A review
74. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage
75. Cancer predictive value of cytogenetic markers used in occupational health surveillance programs
76. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study
77. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens
78. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area
79. How radiation-specific is the dicentric assay?
80. Colour-changing karyotyping: An alternative to M-FISH/SKY
81. Application of automation to the detection of radiation damage using FISH technology
82. Technical report: Automated classification of first and second cycle metaphases
83. Detection of heterozygous carriers of the ataxia-telangiectasia (ATM) gene by G2 phase chromosomal radiosensitivity of peripheral blood lymphocytes
84. Effects of X-irradiation in G1 and G2 on Bloom's Syndrome and normal chromosomes
85. Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder
86. G2 chromosomal radiosensitivity in fanconi's anemia
87. X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness
88. Hypersensitivity to ionizing radiation in cultured cells from Down syndrome patients
89. Cytogenetic responses to G2 phase x-irradiation of cells from retinoblastoma patients
90. Reduced DNA repair in progeria cells and effects of gamma-ray irradiation on UV-induced unscheduled DNA synthesis in normal and progeria cells
91. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders
92. Factors affecting and significance of G2 chromatin radiosensitivity in predisposition to cancer
93. Radiosensitivity in huntington's disease: Implications for pathogenesis and presymptomatic diagnosis
94. Mutagen hypersensitivity in Friedreich's ataxia
95. Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture
96. Chromosomal radiosensitivity of lymphocytes from Alzheimer's disease patients
97. Parkinson's disease and alzheirmer's disease: Hypersensitivity to X-rays in cultured cell lines
98. DNA repair and mutant frequency in schizophrenia
99. How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?
100. Clinical impact of predictive assays for acute and late radiation morbidity
101. Describing patients' normal tissue reactions: Concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Steering Committee of the BioMed2 European Union Concerted Action Programme on the Development of Predictive Tests of Normal Tissue Response to Radiation Therapy
102. Potential clinical impact of normal tissue intrinsic radiosensitivity testing
103. Is chromosome in situ suppression hybridization suited as a predictive test for intrinsic radiosensitivity in cancer patients?
104. Environmental cancer: Who are susceptible?
105. RBE and the primary mechanism of radiation action
106. Induction by radiation of chromosome aberration in Tradescantia
107. Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA
108. Monitoring populations for DNA repair deficiency and for cancer susceptibility
109. Emergence of genetic instability in children treated for leukemia
110. Relevance of environmental alkylating agents to repair protein O6-alkyl-guanine-DNA alkyltransferase: Determination of individual and collective repair capacities of O6-methylguanine
111. Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility
112. Biomarker monitoring of a population residing near uranium mining activities
113. Chromosome damage and DNA repair response in lymphocytes of women who had children with neural tube defects
114. X-ray induction of persistent hypersensitivity to mutation
115. Ultraviolet-light exposure induces a heritable sensitivity to the induction of SCE by mitomycin-C
116. Role of induced genetic instability in the mutagenic effects of chemicals and radiation
117. Carcinogenicity of metal compounds: Possible role of DNA repair inhibition
118. Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells
119. Cobalt(II) inhibits the incision and the polymerization step of nucleotide excision repair in human fibroblasts
120. Inhibition by metals of X-ray and ultraviolet-induced DNA repair in human cells
121. Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane
122. Toxicological interactions between nickel and radiation on chromosome damage and repair
123. The chromosome-based challenge assay using fluorescence in sim hybridization: A possible test for increased cancer susceptibility
124. Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: Identification of a missense variation in the active site region