Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population

Hepatology

Volumn 25, Issue 3, 1997, Pages 593-597

  Biden, Kelli ^a,c   Young, Joanne ^a   Buttenshaw, Ron ^a   Searle, Jeffrey ^a   Cooksley, Graham ^a   Xu, Dong Bo ^b   Leggett, Barbara ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c Bancroft Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 9P; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MUTATION RATE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AUSTRALIA; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED;

EID: 0031043705     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510250317     Document Type: Article

References (12)

1. Okuda K. Hepatocellular carcinoma: recent progress. HEPATOLOGY 1992;15:948-963.
2. Simonetti RG, Camma C, Fiorello F, Politi F, D'Amico G, Pagliaro L. Hepatocellular carcinoma: a worldwide problem and the major risk factors. Dig Dis Sci 1991;36:962-972.
3. Chen DS. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993;262:369-370.
4. Tanaka K, Hirohata T, Koga S, Sugimachi K, Kanematsu T, Ohryohji F, Nawata H, et al. Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population. Cancer Res 1991;51:2842-2847.
5. Sugimura T. Multistep carcinogenesis: a 1992 perspective. Science 1992;258:603-607.
6. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247:49-56.
7. Fearon ER. Genetic alterations underlying colorectal tumorigenesis. Cancer Surv 1992;12:119-136.
8. Stanbridge EJ. Functional evidence for human tumor suppressor genes: chromosome and molecular genetics studies. Cancer Surv 1992;12:5-24.
9. Hsu H, Peng S, Lai P, Sheu J, Chen D, Liu L, Slagle B, et al. Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinoma. Cancer 1994;73:42-47.
10. Fountain JW, Karayiorgon M, Ernstoff MS, Kirkwood JM, Vlock DR, Titus-Ernstoff L, Bouchard B, et al. Homozygous deletions within human chromosome band 9p21 in melanoma. Proc Natl Acad Sci USA 1992;89:10557-10561.
11. Yoshida S, Todoroki T, Ichikawa Y, Hanai S, Suzuki H, Hori M, Fukao K, et al. Mutations of the p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. Cancer Res 1995;55:2756-2760.
12. Liu Q, Yan YX, McClure M, Nakagawa H, Fujimura F, Rustgi AK MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. Oncogene 1995;10:619-622.