Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma

Cancer Letters

Volumn 122, Issue 1-2, 1998, Pages 201-207

  Piao, Zhe ^a   Park, Chanil ^a   Lee, Jin Sung ^a   Yang, Chang Hyun ^a   Choi, Kang Yell ^a   Kim, Hoguen ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

CDKN2; Hepatocellular carcinoma; Homozygous deletions; Loss of heterozygosity

Indexed keywords

PROTEIN;

ARTICLE; CHROMOSOME 9P; CLINICAL ARTICLE; GENE DELETION; GENE MUTATION; GENETIC MARKER; HETEROZYGOSITY LOSS; HUMAN; IMMUNOBLOTTING; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MUTATION;

EID: 0032498316     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00403-5     Document Type: Article

References (40)

1. Harris C.C. Hepatocellular carcinogenesis: recent advances and speculations. Cancer Cells. 2:1990;146-148.
2. Beasley R.P., Hwang L.Y., Lin C.C., Chien C.S. Hepatocellular carcinoma and hepatitis B virus. Lancet. II:1981;1129-1133.
3. Sakamoto M., Hirohashi S., Tsuda H., Ino Y., Shimosato Y., Yamasaki S., Makuuchi M., Hasegawa H., Terada M., Hosoda Y. Increasing incidence of hepatocellular carcinoma possibly associated with non-A non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases. Cancer Res. 48:1988;7294-7297.
4. Saito I., Miyamura T., Ohbayashi A., Harada H., Katayama T., Kikuti S., Watanabe Y., Koi S., Onji M., Ohta Y., Choo Q.L., Houghton M., Kuo G. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA. 87:1990;6547-6549.
5. Tsuda H., Hirohashi S., Shimosato Y., Ino Y., Yoshida T., Terada M. Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma. Jpn. J. Cancer Res. 80:1989;196-199.
6. Tada M., Omata M., Ohto M. Analysis of ras gene mutation in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res. 50:1989;1121-1124.
7. Kamb A., Gruis A.N., Feldhaus W.J., Liu Q., Harshman K., Tavtigian V.S., Stockert E., Day III S.R., Johnson E.B., Skolnick H.M. A cell cycle regulator potentially involved in genesis of many tumor types. Science. 264:1994;436-440.
8. Nobori T., Miura K., Wu J.D., Lois A., Takabayashi K., Carson A.D. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 368:1994;753-756.
9. Serrano M., Hannon G.J., Beach D.A. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704-707.
10. Orlow I., Lacombe L., Hannon J.G., Serrano M., Pellicer I., Dalbagni G., Reuter E.V., Zhang Z.F., Beach D., Cardo C.C. Deletion of the p16 and p15 gene in human bladder tumors. J. Natl. Cancer Inst. 87:1995;1524-1529.
11. Ueki K., Ono Y., Henson W.J., Efird T.J., Deimling V.A., Louis N.D. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res. 56:1996;150-153.
12. Spruck III C.H., Gonzalez-Zulueta M., Shibata A., Simoneau A.R., Lin M.F., Gonzales F., Tsai Y.C., Jones P.A. p16 gene in uncultured tumors. Nature. 370:1994;183-184.
13. Biden K., Young J., Buttenshaw R., Searle J., Cooksley G., Xu D.B., Leggett B. Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology. 25:1997;593-597.
14. INK4 in hepatocellular carcinoma. Hepatology. 24:1996;575-579.
15. INK4 gene in liver cancer. Int. J. Cancer. 67:1996;176-180.
16. Qin L., Tang Z., Liu K., Ye S., He B., Zhang Y., Zhou G. Alterations of CDKN2 (p16/MTS1) exon 2 in human hepatocellular carcinoma. Oncol. Rep. 3:1996;405-408.
17. Yumoto Y., Hanafusa T., Hada H., Morita T., Ooguchi S., Shinji N., Mitani T., Hamaya K., Koide N., Tsuji T. Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinoma. J. Gastroenterol. Hepatol. 10:1995;179-185.
18. Edmondson H.A., Steiner P.E. Primary carcinoma of the liver. A study of 100 cases among 48 900 necropsies. Cancer. 7:1954;462-503.
19. Peng S.Y., Lai T.J., Chu J.S., Lee P.H., Tsung P.T., Chen D.S., Hsu H.C. Expression and hypomethylation of alpha-fetoprotein gene in unicentric and multicentric human hepatocellular carcinomas. Hepatology. 17:1993;35-41.
20. Goelz S.E., Hamilton S.R., Vogelstein B. Purification of DNA from formaldehyde fix and paraffin embedded human tissue. Biochem. Biophys. Res. Commun. 130:1985;118-126.
21. Zulueta G.M., Shibata A., Ohneseit F.P., Spruck III H.C., Busch C., Shamaa M., Elbaz M., Nichols W.P., Gonzalgo L.M., Malmstrom U.P., Jones A.P. High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder. J. Natl. Cancer Inst. 87:1995;1383-1393.
22. Walker D.G., Duan W., Popovic E.A., Kaye A.H., Tomlinson F.H., Lavin M. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of the human astrocytomas. Cancer Res. 55:1995;20-23.
23. Hahn S.A., Hoque A.T.M.S., Moskaluk C.A., da Costa L.T., Schutte M., Rozenblum E., Seymour A.B., Weinstein C.L., Yeo C.J., Hruban R.H., Kern S.E. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res. 56:1996;490-494.
24. ARF in breast cancer. Clin. Cancer Res. 2:1996;1993-1998.
25. Janicke R.U., Lee F.H.H., Porter A.G. Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells. Mol. Cell. Biol. 14:1994;5661-5670.
26. Packenham J.P., Taylor J.A., Anna C.H., White C.M., Devereux T.R. Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors. Mol. Carcinogen. 14:1995;147-151.
27. Dib C., Faure S., Fizames C., Samson D., Drouot N., Vignal A., Millasseau D., Marc S., Hazan J., Sebounm E., Lathrop M., Gyapay G., Morissette J., Weissenbach J. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature. 380:1996;152-154.
28. Piao Z., Choi Y., Park C., Lee W.J., Park J.H., Kim H. Deletion of M6P/IGF2r gene in primary hepatocellular carcinoma. Cancer Lett. 120:1997;39-43.
29. Liggett W.H., Sewell D.A., Rocco J., Ahrendt S.A., Koch W., Sidransky D. p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res. 56:1996;4119-4123.
30. Mori T., Miura K., Aoki T., Nishihira T., Mori S., Nakamura Y. Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res. 54:1994;3396-3397.
31. Caldas C., Hahn S.A., da Costa L.T., Redston M.S., Schutte M., Seymour A.B., Weinstein C.L., Hruban R.H., Yeo C.J., Kern S.E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet. 8:1994;27-32.
32. Chen W., Weghorst C.M., Sabourin C.L.K., Wang Y., Wang D., Bostwick D.G., Stoner G.D. Absence of p16/MTS1 gene mutations in human prostate cancer. Carcinogenesis. 17:1996;2603-2606.
33. Cairns P., Tokino K., Eby Y., Sidransky D. Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction. Cancer Res. 54:1994;1422-1424.
34. ink4) gene alterations in human ovarian tumours. Br. J. Cancer. 74:1996;1069-1073.
35. Ohta M., Berd D., Shimizu M., Nagai H., Cotticelli M., Mastrongelo M., Shields J.A., Shields C.L., Croce C.M., Huebner K. Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma. Int. J. Cancer. 65:1996;762-767.
36. Kim S.K., Ro J.Y., Kemp B.L., Lee J.S., Kwon T.J., Fong K.M., Sekido Y., Minna J.D., Hong W.K., Mao L. Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer. Cancer Res. 57:1997;400-403.
37. Puig S., Ruiz A., Lazaro C., Castel T., Lynch M., Palou J., Vilalta A., Weissenbach J., Mascaro J.M., Estivill X. Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene. Am. J. Hum. Genet. 57:1995;395-402.
38. Jen J., Harper W., Bigner S.H., Bigner D.D., Papadopoulos N., Markowitz S., Willson J.K.V., Kinzler K.W., Vogelstein B. Deletion of p16 and p15 genes in brain tumors. Cancer Res. 54:1994;6353-6358.
39. Theise D.N. Macroregenerative (dysplastic) nodules and hepatocarcinogenesis: theoretical and clinical considerations. Semin. Liver Dis. 15:1995;360-371.
40. Uchida T. Small hepatocellular carcinoma: its relationship to multistep hepatocarcinogenesis. Pathol. Int. 45:1995;175-184.