SCOPUS 정보 검색 플랫폼

Volumn 350, Issue 1, 2000, Pages 253-259

Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 (forkhead activin signal transducer-2)-mediated transcription

(2) Nagarajan, R P a Chen, Y a

a INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

Activin; Serine kinase; Signal transduction; TGF ; Transcription factor

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR; PROTEIN SERINE KINASE; SIGNAL PEPTIDE; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA;

AMINO TERMINAL SEQUENCE; ARTICLE; CHIMERA; GENE EXPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; PHENOTYPE; PROTEIN CONFORMATION; SMAD2 PROTEIN; SMAD3 PROTEIN; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

CHIMAERIFORMES;

EID: 0034663578 PISSN: 02646021 EISSN: None Source Type: Journal
DOI: 10.1042/0264-6021:3500253 Document Type: Article

Times cited : (19)

References (32)

1
- 0031685620
- TGF-beta signal transduction
- (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
- Massague, J.¹

2
- 0031438047
- TGF-beta signalling from cell membrane to nucleus through SMAD proteins
- (1997) Nature (London) , vol.390 , pp. 465-471
- Heldin, C.H.¹ Miyazono, K.² Ten Dijke, P.³

3
- 0032893161
- Roles of pathway-specific and inhibitory Smads in activin receptor signaling
- (1999) Mol. Endocrinol. , vol.13 , pp. 15-23
- Lebrun, J.J.¹ Takabe, K.² Chen, Y.³ Vale, W.⁴

4
- 0030613262
- Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
- (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
- Souchelnytskyi, S.¹ Tamaki, K.² Engstrom, U.³ Wernstedt, C.⁴ Ten Dijke, P.⁵ Heldin, C.H.⁶

5
- 0030613249
- TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
- (1997) J. Biol. Chem. , vol.272 , pp. 27678-27685
- Abdollah, S.¹ Macias-Silva, M.² Tsukazaki, T.³ Hayashi, H.⁴ Attisano, L.⁵ Wrana, J.L.⁶

6
- 0030593038
- DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
- (1996) Science , vol.271 , pp. 350-353
- Hahn, S.A.¹ Schutte, M.² Hoque, A.T.³ Moskaluk, C.A.⁴ Da Costa, L.T.⁵ Rozenblum, E.⁶ Weinstein, C.L.⁷ Fischer, A.⁸ Yeo, C.J.⁹ Hruban, R.H.¹⁰ Kern, S.E.¹¹

7
- 0030690337
- Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
- (1997) Genes Dev. , vol.11 , pp. 3157-3167
- Liu, F.¹ Pouponnot, C.² Massague, J.³

8
- 0032442852
- Smads: Transcriptional activators of TGF-beta responses
- (1998) Cell , vol.95 , pp. 737-740
- Derynck, R.¹ Zhang, Y.² Feng, X.H.³

9
- 0029066689
- Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
- (1995) Science , vol.268 , pp. 1336-1338
- Markowitz, S.¹ Wang, J.² Myeroff, L.³ Parsons, R.⁴ Sun, L.⁵ Lutterbaugh, J.⁶ Fan, R.S.⁷ Zborowska, E.⁸ Kinzler, K.W.⁹ Vogelstein, B.¹⁰

10
- 9344223357
- DPC4 gene in various tumor types
- (1996) Cancer Res. , vol.56 , pp. 2527-2530
- Schutte, M.¹ Hruban, R.H.² Hedrick, L.³ Cho, K.R.⁴ Nadasdy, G.M.⁵ Weinstein, C.L.⁶ Bova, G.S.⁷ Isaacs, W.B.⁸ Cairns, P.⁹ Nawroz, H.¹⁰

11
- 16044369574
- MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
- (1996) Cell , vol.86 , pp. 543-552
- Eppert, K.¹ Scherer, S.W.² Ozcelik, H.³ Pirone, R.⁴ Hoodless, P.⁵ Kim, H.⁶ Tsui, L.C.⁷ Bapat, B.⁸ Gallinger, S.⁹ Andrulis, I.L.¹⁰

12
- 0032544448
- Smad3 mutant mice develop metastatic colorectal cancer
- (1998) Cell , vol.94 , pp. 703-714
- Zhu, Y.¹ Richardson, J.A.² Parada, L.F.³ Graff, J.M.⁴

13
- 0032110463
- Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
- (1998) Mol. Cell , vol.2 , pp. 109-120
- Labbe, E.¹ Silvestri, C.² Hoodless, P.A.³ Wrana, J.L.⁴ Attisano, L.⁵

14
- 0032483544
- Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
- (1998) Cell , vol.94 , pp. 585-594
- Shi, Y.¹ Wang, Y.F.² Jayaraman, L.³ Yang, H.⁴ Massague, J.⁵ Pavletich, N.P.⁶

15
- 0032014216
- Human Smad3 and Smad4 are sequence-specific transcription activators
- (1998) Mol. Cell , vol.1 , pp. 611-617
- Zawel, L.¹ Dai, J.L.² Buckhaults, P.³ Zhou, S.⁴ Kinzler, K.W.⁵ Vogelstein, B.⁶ Kern, S.E.⁷

16
- 0032101178
- Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
- (1998) EMBO J , vol.17 , pp. 3091-3100
- Dennler, S.¹ Itoh, S.² Vivien, D.³ Ten Dijke, P.⁴ Huet, S.⁵ Gauthier, J.M.⁶

17
- 0033534573
- Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
- (1999) J. Biol. Chem. , vol.274 , pp. 703-709
- Yagi, K.¹ Goto, D.² Hamamoto, T.³ Takenoshita, S.⁴ Kato, M.⁵ Miyazono, K.⁶

18
- 0029806078
- Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins
- (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 12992-12997
- Chen, Y.¹ Lebrun, J.J.² Vale, W.³

19
- 0029834067
- Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
- (1996) Nature (London) , vol.383 , pp. 832-836
- Lagna, G.¹ Hata, A.² Hemmati-Brivanlou, A.³ Massague, J.⁴

20
- 0033615702
- Smad3 inhibits transforming growth factor-beta and activin signaling by competing with smad4 for FAST-2 binding
- (1999) J. Biol. Chem. , vol.274 , pp. 31229-31235
- Nagarajan, R.P.¹ Liu, J.² Chen, Y.³

21
- 0030667930
- Smad8 mediates the signaling of the ALK-2 receptor serine kinase
- (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 12938-12943
- Chen, Y.¹ Bhushan, A.² Vale, W.³

22
- 0032539690
- Erratum
- (1998) Proc. Natl. Acad. Sci. U.S.A , vol.95 , pp. 1968

23
- 0033584854
- Regulation of smad7 promoter by direct association with smad3 and smad4
- (1999) J. Biol. Chem. , vol.274 , pp. 33412-33418
- Nagarajan, R.P.¹ Zhang, J.² Li, W.³ Chen, Y.⁴

24
- 0032909167
- FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals
- (1999) Mol. Cell. Biol. , vol.19 , pp. 424-430
- Liu, B.¹ Dou, C.L.² Prabhu, L.³ Lai, E.⁴

25
- 0032414597
- A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis
- (1998) Mech. Dev. , vol.79 , pp. 17-27
- Weisberg, E.¹ Winnier, G.E.² Chen, X.³ Farnsworth, C.L.⁴ Hogan, B.L.⁵ Whitman, M.⁶

26
- 0029802485
- A transcriptional partner for MAD proteins in TGF-beta signalling
- (1996) Nature (London) , vol.383 , pp. 691-696
- Chen, X.¹ Rubock, M.J.² Whitman, M.³

27
- 0030593898
- Erratum
- (1996) Nature (London) , vol.384 , pp. 648

28
- 0029892494
- MADR1, a MAD-related protein that functions in BMP2 signaling pathways
- (1996) Cell , vol.85 , pp. 489-500
- Hoodless, P.A.¹ Haerry, T.² Abdollah, S.³ Stapleton, M.⁴ O'Connor, M.B.⁵ Attisano, L.⁶ Wrana, J.L.⁷

29
- 0029931509
- A human Mad protein acting as a BMP-regulated transcriptional activator
- (1996) Nature (London) , vol.381 , pp. 620-623
- Liu, F.¹ Hata, A.² Baker, J.C.³ Doody, J.⁴ Carcamo, J.⁵ Harland, R.M.⁶ Massague, J.⁷

30
- 0032110707
- Characterization of human FAST-1, a TGF beta and activin signal transducer
- (1998) Mol. Cell , vol.2 , pp. 121-127
- Zhou, S.¹ Zawel, L.² Lengauer, C.³ Kinzler, K.W.⁴ Vogelstein, B.⁵

31
- 0033543741
- The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
- (1999) J. Biol. Chem. , vol.274 , pp. 26584-26590
- Yeo, C.Y.¹ Chen, X.² Whitman, M.³

32
- 0033602186
- A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
- (1999) Oncogene , vol.18 , pp. 1643-1648
- Dennler, S.¹ Huet, S.² Gauthier, J.M.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.