Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro

Neuroscience Letters

Volumn 269, Issue 3, 1999, Pages 178-182

  Eggert, Karla ^a   Schlegel, Jürgen ^a   Oertel, Wolfgang ^a   Würz, Cornelia ^a   Krieg, Jürgen Christian ^a   Vedder, Helmut ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

6 Hydroxydopamine; Glial cell line derived neurotrophic factor; Glial cell line derived neurotrophic factor receptor ; Mesencephalic cultures; Ret

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CYTOTOXICITY; DISEASE MODEL; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DOPAMINE; DROSOPHILA PROTEINS; EMBRYO; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; MESENCEPHALON; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TYROSINE 3-MONOOXYGENASE;

EID: 0033575432     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00443-7     Document Type: Article

References (19)

1. Beck D.B., Knüsel B., Winslow J.W., Rosenthal A., Burton L.E., Nikolics K., Hefti F. Pretreatment of dopaminergic neurons in culture with brain-derived neurotrophic factor attenuates toxicity of 1-methyl-4-phenylpyridinium. Neurodegeneration. 1:1992;27-36.
2. Beck D.B., Valverde J., Alexl T., Poulsen K., Moffat B., Vandlen R., Rosenthal A., Hefti F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373:1995;339-341.
3. Chadi G., Moller A., Rosen L., Janson A.M., Goldstein M., Ögren S.O., Pettersson R.F., Fuxe K. Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion. Exp. Brain. Res. 97:1993;145-158.
4. Creedon D.J., Tansey M.G., Baloh R.H., Osborne P.A., Lampe P.A., Fahrner T.J., Heuckeroth R.O., Milbrandt J., Johnson Jr E.M. Neurturin shares receptor and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc. Natl. Acad. Sci. USA. 94:1997;7018-7023.
5. Durbec P., Marcos Gutierrez C.V., Kilkenny C., Grigoriou M., Wartiowaara K., Suvanto P., Smith D., Ponder B., Costantini R., Saamra M. GDNF signalling through the Ret receptor tyrosine kinase. Nature. 381:1996;789-793.
6. Engele J., Bohn M.C. The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. J. Neurosci. 11:1991;3070-3078.
7. Gash D.M., Zhang Z., Ovadia A., Cass W.A., Yi A., Simmerman L., Russel D., Martin D., Lapchak P.A., Collins F., Hoffer B.J., Gerhard A. Functional recovery in parkinsonian monkeys treated with GDNF. Nature. 380:1996;252-255.
8. Hou J.G., Cohen G., Mytilineou C. Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-Hydroxydopamine toxicity: involvement of the glutathione system. J. Neurochem. 69:1997;76-83.
9. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 350:1991;230-232.
10. Jing S., Wen D., Yu Y., Holst P.L., Luo Y., Fang M., Tamir R., Antonio L., Hu Z., Cupples R., Louis J.C., Hu S., Altrock B.W., Fox G.M. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-, a novel receptor for GDNF. Cell. 85:1996;1113-1124.
11. Klein R.D., Sherman D., Ho W.H., Stone D., Bennet G.L., Moffat B., Vandlen R., Simmons L., Gu Q., Hongo J.H., Devaux B., Poulsen K., Armanini M., Nozaki C., Asai N., Goddard A., Phillips H., Henderson C.E., Takahashi M., Rosenthal A. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature. 387:1997;717-721.
12. Knüsel B., Michel P.P., Schwaber J.S., Hefti F. Selective and unselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J. Neurosci. 10:1990;558-570.
13. Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1132.
14. +: specificity and impact of cultured conditions, non-dopaminergic neurons, and astroglial cells. J. Neurosci. Res. 34:1993;382-393.
15. +)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF. Brain. Res. 599:1992;83-97.
16. Sauer H., Oertel W.H. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience. 59:1994;401-415.
17. Sauer H., Rosenblad C., Björklund A. GDNF but not TGF-3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc. Natl. Acad. Sci. USA. 92:1995;8935-8939.
18. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. J. Neurochem. 59:1992;99-106.
19. Tomac A., Lindqvist E., Lin L.F., Ögren S.O., Young D., Hoffer B.J., Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373:1995;335-339.