UCN-01 (7-hydroxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery

Japanese Journal of Cancer Research

Volumn 92, Issue 5, 2001, Pages 537-545

  Abe, Sadanori ^a   Kubota, Tetsuro ^a   Otani, Yoshihide ^a   Furukawa, Toshiharu ^a   Watanabe, Masahiko ^a   Kumai, Koichiro ^a   Akiyama, Tadakazu ^b   Akinaga, Shiro ^b   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Human xenografts; In vivo sensitivity; UCN 01

Indexed keywords

7 HYDROXYSTAUROSPORINE; CYCLIN DEPENDENT KINASE 2; GENE PRODUCT; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INJECTION; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT; WEIGHT;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CDC2-CDC28 KINASES; CELL DIVISION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; G1 PHASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; STAUROSPORINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034991305     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01127.x     Document Type: Article

References (46)

1. Cancer cell cycles
2. Differential phosphorylation of vertebrate p34cdc2 kinase of the G2/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites
3. Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis
4. Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates
5. UCN-01, 7-hydroxystaurosporine, inhibits kinase activity of cyclin-dependent kinase and reduces the phosphorylation of the retinoblastoma susceptibility gene product in an A549 human lung carcinoma cell line
6. DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control
7. WAF1, a potential mediator of p53 tumor suppression
8. The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases
9. INK4
10. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
11. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
12. Kip1 protein: Prognostic implications in primary breast cancer
13. Increased proteosome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinoma
14. Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
15. CVT 313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation
16. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
17. Biochemical and cellular effects of roscovotine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2, and cdk5
18. Chemical inhibitors of cyclin-dependent kinases
19. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
20. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells
21. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation
22. Analogs of staurosporine: Potential anticancer drugs?
23. Modulation of apoptosis in rat thymocytes by analogs of staurosporine: Lack of direct association with inhibition of protein kinase C
24. The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibroblast
25. Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cells
26. Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma A431 cells
27. G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation
28. Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models
29. RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma
30. p53, the cellular gatekeeper for growth and division
31. p53 is required for radiation induced apoptosis in mouse thymocytes
32. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
33. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis
34. K-ras and p53 mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
35. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
36. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor suppressor genes
37. Chemosensitivity of human pancreatic cancer cell lines serially transplanted in nude mouse
38. Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: Sensitivity to asparaginase
39. Heterotransplantation of human malignant tumors in "nude" thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors
40. Cell kinetics and chemosensitivity of human carcinoma serially transplanted into nude mice
41. Antitumor activity of paclitaxel against human breast carcinoma xenografts serially transplanted into nude mice
42. Protocols for screening chemical agents and natural products against animal tumors and other biological systems
43. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
44. Cloning of p27Kip1, a cyclin dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
45. Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-hydroxystaurosporine)
46. UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA