Alteration of Bcl-2 expression in the nigrostriatal system after kainate injection with or without melatonin co-treatment

Journal of Chemical Neuroanatomy

Volumn 21, Issue 3, 2001, Pages 215-223

  Chuang, J I ^a   Chen, S T ^b   Chang, Y H ^a   Jen, L S ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Bcl 2; Kainate; Melatonin; Neuroprotection; Nigrostriatal pathway

Indexed keywords

KAINIC ACID; MELATONIN; PROTEIN BCL 2; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; MALE; NERVE; NICK END LABELING; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; RAT;

ACTINS; ANIMALS; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; ANTIOXIDANTS; AVIAN PROTEINS; BLOOD PROTEINS; CORPUS STRIATUM; EXCITATORY AMINO ACID AGONISTS; KAINIC ACID; MALE; MELATONIN; MEMBRANE GLYCOPROTEINS; MICROGLIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 0034982924     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(01)00109-0     Document Type: Article

References (48)

1. Intrastriatal kainic acid: Acute effects on electrophysiological and biochemical measures of nigrostriatal dopaminergic activity
2. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid β-peptide
3. Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons
4. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degeneration
5. The antioxidant role of melatonin prevents kainate-induced neuronal damage in rats
6. Bcl-2 proto-oncogene protein immuno-reactivity in normal developing and axotomised rat retinas
7. Distribution of β-amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina after optic nerve transection or vascular lesion
8. Expression of amyloid precursor and bcl-2 proto-oncogene proteins in rat retinas after intravitreal injection of aminoadipic acid
9. Melatonin administration protect CA1 hippocampal neurons after transient forebrain ischemia in rats
10. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats
11. Neonatal motoneurons overexpressing the bcl-2 proto-oncogene in transgenic mice are protected from axotomy-induced cell death
12. Increased expression of mRNA encoding interleukin-1b and caspase-1, and secreted isoform of interleukin receptor antagonist in the rat brain following systemic kainic acid administration
13. bcl-2 transgene expression can protect neurons against developmental and induced cell death
14. Bcl-2, Bax, and Bcl-x expression in the CA1 area of the hippocampus following transient forebrain ischemia in the adult gerbil
15. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain
16. Reactive glia as rivals in regulating neuronal survival
17. Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity
18. Neuroprotection by melatonin from kainite-induced excitotoxicity in rats
19. Basic FGF in adult rat brain: Cellular distribution and response to entorhinal lesion and fimbria-fornix transection
20. The trophic factors S100 and basic fibroblast growth factor are increased in the forebrain reactive astrocytes of adult callosotomised rat
21. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
22. Alzheimer's peptide kills cells of retina in vivo
23. Effects of melatonin on macrophages/microglia in postnatal rat brain
24. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia
25. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
26. Expression of pro- anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis
27. Microglia: A sensor for pathological events in the CNS
28. The proto-oncogene bcl-2 and its role in regulating apoptosis
29. Bcl-2, Bax and Bcl-x expression following kainic acid administration at convulsant doses in the rat
30. Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus
31. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
32. Alterations of Bcl-2 family proteins precede cytoskeletal proteolysis in the penumbra, but not in infarct centers following focal cerebral ischemia in mice
33. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
34. Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen
35. A review of the evidence supporting melatonion's role as an antioxidant
36. Actions of melatonin in the reduction of oxidative stress
37. Melatonin suppression of PC12 cell growth and death
38. 35S]butylbicyclophosphorothionate binding sites elicited by the degeneration of the striato-nigral GABAergic pathway: Reversal by diazepam
39. Involvement of free radicals in excitotoxicity in vivo
40. Widespread patterns of neuronal damage following systemic or intracerebral injection of kainic acid: A histological study
41. Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
42. Kainic acid induces apoptosis in neurons
43. Macrophage and microglial response to cytokines in vitro: Phagocytic activity, proteolytic enzyme release, and free radical production
44. Kainic acid-induced neurochemical and histopathological changes
45. Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainite to rats
46. Bcl-2 expression causes redistribution of glutathione to the nucleus
47. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked